Delayed inactivation of TRPC6 as a determinative characteristic of FSGS-associated variants.
Ryo Okada; Reiko Sakaguchi; Tatsuya Komaki; Ryu Nonaka; Onur K Polat; Takanori Kihara; Katsuhiko Asanuma; Takeshi Yamamoto; Yoshitaka Isaka; Yasuo Mori; Masayuki X Mori
The Journal of biological chemistry, 2025年06月, 査読あり
ラスト(シニア)オーサー, 責任著者

Dynamic remodeling of TRPC5 channel–caveolin-1–eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals
Reiko Sakaguchi; Nobuaki Takahashi; Takashi Yoshida; Nozomi Ogawa; Yoshifumi Ueda; Satoshi Hamano; Kaori Yamaguchi; Seishiro Sawamura; Shinichiro Yamamoto; Yuji Hara; Tomoya Kawamoto; Ryosuke Suzuki; Akito Nakao; Masayuki X. Mori; Tetsushi Furukawa; Shunichi Shimizu; Ryuji Inoue; Yasuo Mori
Journal of Biological Chemistry, 2024年09月

新規選択的TRPC3/6チャネル阻害剤がラットPAN-誘導性蛋白尿の成分に与える影響
坂口 怜子; 松田 由宗; 岡田 亮; 石兼 真; 高橋 富美; 片渕 瑛介; 中山 敏幸; 眞田 賢哉; 上田 陽一; 永田 龍; 森 誠之
産業医科大学雑誌, 2023年03月

Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation
Masayuki X. Mori; Ryo Okada; Reiko Sakaguchi; Hideharu Hase; Yuko Imai; Onur K. Polat; Satoru G. Itoh; Hisashi Okumura; Yasuo Mori; Yasushi Okamura; Ryuji Inoue
Scientific Reports, 2022年12月

N-Methylamide-structured SB366791 derivatives with high TRPV1 antagonistic activity: toward PET radiotracers to visualize TRPV1
Tatsuya Kida; Nobuaki Takahashi; Masayuki X. Mori; Jiacheng H. Sun; Hideto Oota; Kosuke Nishino; Takashi Okauchi; Yuta Ochi; Daisuke Kano; Ukihide Tateishi; Yasuyoshi Watanabe; Yilong Cui; Yasuo Mori; Hisashi Doi
RSC Medicinal Chemistry, 2022年

Extreme deformability of insect cell membranes is governed by phospholipid scrambling
Akifumi Shiomi; Kohjiro Nagao; Nobuhiro Yokota; Masaki Tsuchiya; Utako Kato; Naoto Juni; Yuji Hara; Masayuki X. Mori; Yasuo Mori; Kumiko Ui-Tei; Motohide Murate; Toshihide Kobayashi; Yuri Nishino; Atsuo Miyazawa; Akihisa Yamamoto; Ryo Suzuki; Stefan Kaufmann; Motomu Tanaka; Kazuya Tatsumi; Kazuyoshi Nakabe; Hirofumi Shintaku; Semen Yesylevsky; Mikhail Bogdanov; Masato Umeda
Cell Reports, 2021年06月

Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis
Atsushi Masamune; Hiroshi Kotani; Franziska Lena Sörgel; Jian-Min Chen; Shin Hamada; Reiko Sakaguchi; Emmanuelle Masson; Eriko Nakano; Yoichi Kakuta; Tetsuya Niihori; Ryo Funayama; Matsuyuki Shirota; Tatsuya Hirano; Tetsuya Kawamoto; Atsuki Hosokoshi; Kiyoshi Kume; Lara Unger; Maren Ewers; Helmut Laumen; Peter Bugert; Masayuki X. Mori; Volodymyr Tsvilovskyy; Petra Weißgerber; Ulrich Kriebs; Claudia Fecher-Trost; Marc Freichel; Kalliope N. Diakopoulos; Alexandra Berninger; Marina Lesina; Kentaro Ishii; Takao Itoi; Tsukasa Ikeura; Kazuichi Okazaki; Tom Kaune; Jonas Rosendahl; Masao Nagasaki; Yasuhito Uezono; Hana Algül; Keiko Nakayama; Yoichi Matsubara; Yoko Aoki; Claude Férec; Yasuo Mori; Heiko Witt; Tooru Shimosegawa
Gastroenterology, 2020年05月

Engineering an enhanced voltage-sensing phosphatase
Akira Kawanabe; Natsuki Mizutani; Onur K Polat; Tomoko Yonezawa; Takafumi Kawai; Masayuki X Mori; Yasushi Okamura
The Journal of General Physiology, 2020年, 査読あり, 招待無し

Ryanodine receptor mutations (G4946E and I4790K) differentially responsible for diamide insecticide resistance in diamondback moth, Plutella xylostella L.
Jouraku A; Kuwazaki S; Miyamoto K; Uchiyama M; Kurokawa T; Mori E; Mori MX; Mori Y; Sonoda S
Insect biochemistry and molecular biology, 2019年12月, 査読あり, 招待無し

Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia
Daisuke Yamazaki; Ayaka Hasegawa; Yosuke Funato; Nam Tran Ha; Masayuki X. Mori; Yasuo Mori; Toshiro Sato; Hiroaki Miki
ONCOGENE, 2019年05月, 査読あり, 招待無し

Contribution of Coiled-coil Assembly to Ca2+/Calmodulin-dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-associated Phenotypes
Polat, Onur; Uno, Masatoshi; Maruyama, Terukazu; Tran, Ha; Imamura, Kayo; Wong, Chee Fah; Sakaguchi, Reiko; Ariyoshi, Mariko; Kyohei , Itsuki; Ichikawa, Jun; Morii, Takashi; Shirakawa, Masahiro; Inoue, Ryuji; Asanuma, Katsuhiko; Reiser, Jochen; Tochio, Hidehito; Mori, Yasuo; Mori, Masayuki
Journal of the American Society of Nephrology, 2019年, 査読あり, 招待無し

ELKS/Voltage-Dependent Ca2+ Channel-beta Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic beta Cells
Mica Ohara-Imaizumi; Kyota Aoyagi; Hajime Yamauchi; Masashi Yoshida; Masayuki X. Mori; Yamato Hida; Ha Nam Tran; Masamichi Ohkura; Manabu Abe; Yoshihiro Akimoto; Yoko Nakamichi; Chiyono Nishiwaki; Hayato Kawakami; Kazuo Hara; Kenji Sakimura; Shinya Nagamatsu; Yasuo Mori; Junichi Nakai; Masafumi Kakei; Toshihisa Ohtsuka
CELL REPORTS, 2019年01月, 査読あり, 招待無し

Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation
Tsuchiya Masaki; Hara Yuji; Okuda Masaki; Itoh Karin; Nishioka Ryotaro; Shiomi Akifumi; Nagao Kohjiro; Mori Masayuki; Mori Yasuo; Ikenouchi Junichi; Suzuki Ryo; Tanaka Motomu; Ohwada Tomohiko; Aoki Junken; Kanagawa Motoi; Toda Tatsushi; Nagata Yosuke; Matsuda Ryoichi; Takayama Yasunori; Tominaga Makoto; Umeda Masato
NATURE COMMUNICATIONS, 2018年05月, 査読あり, 招待無し

Ca2+-Dependent Inactivation Mediated by Calmodulin in TRPC6 Channel Underlies FSGS Channelopathy
Masatoshi Uno; Onur K. Polat; Ha Nam Tran; Shota Yamaji; Yasuo Mori; Hidehito Tochio; Masayuki X. Mori
BIOPHYSICAL JOURNAL, 2018年02月, 査読なし, 招待無し

Functional Charaterization of Zebrafish Transient Receptor Potential Melastatin 2
Ha Nam Tran; Jure Hederih; Tomohiro Numata; Masayuki X. Mori; Shingo Maegawa; Hiroshi Hosokawa; Yasuo Mori
BIOPHYSICAL JOURNAL, 2018年02月, 査読なし, 招待無し

Uncovering the arrhythmogenic potential of TRPM4 activation in atrial-derived HL-1 cells using novel recording and numerical approaches
Yaopeng Hu; Yubin Duan; Ayako Takeuchi; Lin Hai-Kurahara; Jun Ichikawa; Keizo Hiraishi; Tomohiro Numata; Hiroki Ohara; Gentaro Iribe; Michio Nakaya; Masayuki X. Mori; Satoshi Matsuoka; Genshan Ma; Ryuji Inoue
CARDIOVASCULAR RESEARCH, 2017年08月

C-terminal splice variants of P/Q-type Ca²⁺ channel Ca_V2.1 α₁ subunits are differentially regulated by Rab3-interacting molecule proteins.
Hirano M; Takada Y; Wong CF; Yamaguchi K; Kotani H; Kurokawa T; Mori MX; Snutch TP; Ronjat M; De Waard M; Mori Y
The Journal of biological chemistry, 2017年06月, 査読あり, 招待無し

Calmodulin and ATP support activity of the Cav1.2 channel through dynamic interactions with the channel
Etsuko Minobe; Masayuki X. Mori; Masaki Kameyama
JOURNAL OF PHYSIOLOGY-LONDON, 2017年04月, 査読あり, 招待無し

Multi-point interaction between P/Q-type voltage-dependent Ca2+ channel and alpha-RIMs augments RIMs suppressive effect on voltage dependent inactivation
Mitsuru Hirano; Kazuma Yamaguchi; Yoshinori Takada; Takeshi Kotani; Tatsuki Kurokawa; Masayuki. X. Mori; Yasuo Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2017年03月, 査読なし, 招待無し

FUNCTIONAL CHARATERIZATION OF ZEBRAFISH TRANSIENT RECEPTOR POTENTIAL MELASTATIN 2 IN HEK 293 CELL LINE
Ha Nam Tran; Tomohiro Numata; Masayuki X. Mori; Shingo Maegawa; Hiroshi Hosokawa; Shingo Tanaka; Yasuo Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2017年03月, 査読なし, 招待無し

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds
Sawamura S; Hatano M; Takada Y; Hino K; Kawamura T; Tanikawa J; Nakagawa H; Hase H; Nakao A; Hirano M; Rotrattanadumrong R; Kiyonaka S; Mori MX; Nishida M; Hu Y; Inoue R; Nagata R; Mori Y
Mol Pharmacol., 2016年, 査読あり, 招待無し

Post-transcriptional modifications and "Calmodulation" of voltage-gated calcium channel function: Reflections by two collaborators of David T Yue
Tuck Wah Soong; Masayuki X. Mori
CHANNELS, 2016年01月, 査読あり, 招待有り

Rab3 interacting molecule 3 mutations associated with autism alter regulation of voltage-dependent Ca2+ channels
Yoshinori Takada; Mitsuru Hirano; Shigeki Kiyonaka; Yoshifumi Ueda; Kazuma Yamaguchi; Keiko Nakahara; Masayuki X. Mori; Yasuo Mori
CELL CALCIUM, 2015年09月, 査読あり, 招待無し

Dynamics of receptor-operated Ca2+ currents through TRPC channels controlled via the PI(4,5),P-2-PLC signaling pathway
Masayuki X. Mori; Kyohei Itsuki; Hideharu Hese; Seishiro Sawamura; Tatsuki Kurokawa; Yasuo Mori; Ryuji Inoue
FRONTIERS IN PHARMACOLOGY, 2015年02月, 査読あり, 招待有り

New Experimental Trends for Phosphoinositides Research on Ion Transporter/Channel Regulation
Masayuki X. Mori; Ryuji Inoue
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014年11月, 査読あり, 招待有り

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P₂.
Takahashi N; Hamada-Nakahara S; Itoh Y; Takemura K; Shimada A; Ueda Y; Kitamata M; Matsuoka R; Hanawa-Suetsugu K; Senju Y; Mori MX; Kiyonaka S; Kohda D; Kitao A; Mori Y; Suetsugu S
Nature communications, 2014年09月, 査読あり, 招待無し

Bridge between the channel and FRET of PtdIns(4,5)P₂ sensor.
Mori MX
Channels (Austin, Tex.), 2014年07月, 査読あり, 招待有り

PLC-mediated PI(4,5)P-2 hydrolysis regulates activation and inactivation of TRPC6/7 channels
Kyohei Itsuki; Yuko Imai; Hideharu Hase; Yasushi Okamura; Ryuji Inoue; Masayuki X. Mori
JOURNAL OF GENERAL PHYSIOLOGY, 2014年02月, 査読あり, 招待無し

A human Dravet syndrome model from patient induced pluripotent stem cells
Norimichi Higurashi; Taku Uchida; Christoph Lossin; Yoshio Misumi; Yohei Okada; Wado Akamatsu; Yoichi Imaizumi; Bo Zhang; Kazuki Nabeshima; Masayuki X. Mori; Shutaro Katsurabayashi; Yukiyoshi Shirasaka; Hideyuki Okano; Shinichi Hirose
MOLECULAR BRAIN, 2013年05月, 査読あり, 招待無し

Voltage-sensing phosphatase reveals temporal regulation of TRPC3/C6/C7 channels by membrane phosphoinositides
Kyohei Itsuki; Yuko Imai; Yasushi Okamura; Kihachiro Abe; Ryuji Inoue; Masayuki X. Mori
CHANNELS, 2012年05月, 査読あり, 招待無し

A self-limiting regulation of vasoconstrictor-activated TRPC3/C6/C7 channels coupled to PI(4,5)P₂-diacylglycerol signalling.
Imai Y; Itsuki K; Okamura Y; Inoue R; Mori MX
The Journal of physiology, 2012年02月, 査読あり, 招待無し

Quantitative Measurement of Ca2+-Dependent Calmodulin-Target Binding by Fura-2 and CFP and YFP FRET Imaging in Living Cells
Masayuki X. Mori; Yuko Imai; Kyohei Itsuki; Ryuji Inoue
BIOCHEMISTRY, 2011年05月, 査読あり, 招待無し

Chemical-mechanical synergism for cardiovascular TRPC6 channel activation via PLC/diacylglycerol and PLA2/omega-hydroxylase/20-HETE pathways.
Inoue R; Mori M; Kawarabayashi Y; Jian Z
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2009年09月, 査読あり, 招待無し

心血管TRPチャネルを巡る病態生理の新展開
井上隆司; 瓦林精広; 森誠之
日本心電図学会誌(Jpn. J. Electrocardiology, 2009年, 査読なし, 招待無し

血管受容体作動性CaチャネルTRPC6の受容体・機械刺激による相乗活性化機構
井上 隆司; 瓦林 靖広; 高橋 眞一; 海 琳; 森 誠之; 本田 啓
日本生理学会大会発表要旨集, 2008年

Stable expression and characterization of human PN1 and PN3 sodium channels
Akiba, I; T Seki; M Mori; M Iizuka; S Nishimura; S Sasaki; K Imoto; EL Barsoumian
RECEPTORS & CHANNELS, 2003年09月, 査読あり, 招待無し

蛋白尿改善を目指したイオンチャネル阻害剤の開発と評価
坂口怜子, 松田由宗, 岡田亮, 石兼真, 高橋富美, 片渕瑛介, 中山敏幸, 眞田賢哉 上田陽一, 木原隆典, 永田龍, 森誠之
Journal of UOEH, 2024年03月, 査読あり, 指定なし
ラスト(シニア)オーサー

生化学・分子生物学　腎変性"FSGS"の発症を抑制するTRPC6のカルシウム依存的不活性化機構(CDI)
森 誠之, 岡田 亮
医学のあゆみ, 2020年07月, 査読なし, 招待有り
筆頭著者

Novel interaction of the voltage-dependent sodium channel (VDSC) with calmodulin: does VDSC acquire calmodulin-mediated Ca2+-sensitivity?
Takashi Konno, Takeaki Ozawa, Masayuki Murata, Keiji Imoto, Kuniaki Nagayama
Biochemistry, 2000年03月, 査読あり, 招待無し
筆頭著者

ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells.
Ohara-Imaizumi M1, Aoyagi K2, Yamauchi H3, Yoshida M4, Mori MX5, Hida Y3, Tran HN6, Ohkura M7, Abe M8, Akimoto Y9, Nakamichi Y2, Nishiwaki C2, Kawakami H9, Hara K4, Sakimura K10, Nagamatsu S11, Mori Y12, Nakai J7, Kakei M4, Ohtsuka T13.
Cell reports (Cambridge), 2019年01月, 査読あり, 指定なし

Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis.
Masamune Atsushi, Kotani Hiroshi, Sörgel Franziska Lena, Chen Jian-Min, Hamada Shin, Sakaguchi Reiko, Masson Emmanuelle, Nakano Eriko, Kakuta Yoichi, Niihori Tetsuya, Funayama Ryo, Shirota Matsuyuki, Hirano Tatsuya, Kawamoto Tetsuya, Hosokoshi Atsuki, Kume Kiyoshi, Unger Lara, Ewers Maren, Laumen Helmut, Bugert Peter, Mori Masayuki X, Tsvilovskyy Volodymyr, Weißgerber Petra, Kriebs Ulrich, Fecher-Trost Claudia, Freichel Marc, Diakopoulos Kalliope N, Berninger Alexandra, Lesina Marina, Ishii Kentaro, Itoi Takao, Ikeura Tsukasa, Okazaki Kazuichi, Kaune Tom, Rosendahl Jonas, Nagasaki Masao, Uezono Yasuhito, Algül Hana, Nakayama Keiko, Matsubara Yoichi, Aoki Yoko, Férec Claude, Mori Yasuo, Witt Heiko, Shimosegawa Tooru
Gastroenterology, 2020年05月, 査読あり, 指定なし

Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals.
Reiko Sakaguchi,Nobuaki Takahashi,Takashi Yoshida,Nozomi Ogawa,Yoshifumi Ueda,Satoshi Hamano,Kaori Yamaguchi,Seishiro Sawamura,Shinichiro Yamamoto,Yuji Hara,Tomoya Kawamoto,Ryosuke Suzuki,Akito Nakao,Masayuki X Mori,Tetsushi Furukawa,Shunichi Shimizu,Ryuji Inoue,Yasuo Mori
The Journal of biological chemistry, 2024年08月, 査読あり, 招待無し

Delayed inactivation of TRPC6 as a determinative characteristic of FSGS-associated variants.
Okada Ryo, Sakaguchi Reiko, Komaki Tatsuya, Nonaka Ryu, Polat Onur K, Kihara Takanori, Asanuma Katsuhiko, Yamamoto Takeshi, Isaka Yoshitaka, Mori Yasuo, Mori Masayuki X
The Journal of biological chemistry, 2025年05月, 査読あり, 指定なし
ラスト(シニア)オーサー, 責任著者

Engineering an enhanced voltage-sensing phosphatase.
Kawanabe Akira, Mizutani Natsuki, Polat Onur K, Yonezawa Tomoko, Kawai Takafumi, Mori Masayuki X, Okamura Yasushi
The Journal of general physiology, 2020年05月, 査読あり, 招待有り

Contribution of Coiled-Coil Assembly to Ca2+/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes.
Polat Onur K, Uno Masatoshi, Maruyama Terukazu, Tran Ha Nam, Imamura Kayo, Wong Chee Fah, Sakaguchi Reiko, Ariyoshi Mariko, Itsuki Kyohei, Ichikawa Jun, Morii Takashi, Shirakawa Masahiro, Inoue Ryuji, Asanuma Katsuhiko, Reiser Jochen, Tochio Hidehito, Mori Yasuo, Mori Masayuki X
Journal of the American Society of Nephrology : JASN, 2019年07月, 査読あり, 指定なし
責任著者

Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia.
Yamazaki Daisuke, Hasegawa Ayaka, Funato Yosuke, Tran Ha Nam, Mori Masayuki X, Mori Yasuo, Sato Toshiro, Miki Hiroaki
Oncogene, 2019年05月, 査読あり, 指定なし

Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation.
Mori Masayuki X, Okada Ryo, Sakaguchi Reiko, Hase Hideharu, Imai Yuko, Polat Onur K, Itoh Satoru G, Okumura Hisashi, Mori Yasuo, Okamura Yasushi, Inoue Ryuji
Scientific reports, 2022年06月, 査読あり, 招待無し
筆頭著者

Extreme deformability of insect cell membranes is governed by phospholipid scrambling.
Shiomi Akifumi, Nagao Kohjiro, Yokota Nobuhiro, Tsuchiya Masaki, Kato Utako, Juni Naoto, Hara Yuji, Mori Masayuki X, Mori Yasuo, Ui-Tei Kumiko, Murate Motohide, Kobayashi Toshihide, Nishino Yuri, Miyazawa Atsuo, Yamamoto Akihisa, Suzuki Ryo, Kaufmann Stefan, Tanaka Motomu, Tatsumi Kazuya, Nakabe Kazuyoshi, Shintaku Hirofumi, Yesylevsky Semen, Bogdanov Mikhail, Umeda Masato
Cell reports, 2021年06月, 指定なし, 招待有り

Ryanodine receptor mutations (G4946E and I4790K) differentially responsible for diamide insecticide resistance in diamondback moth, Plutella xylostella L.
Jouraku Akiya, Kuwazaki Seigo, Miyamoto Kazuhisa, Uchiyama Makoto, Kurokawa Tatsuki, Mori Emiko, Mori Masayuki X, Mori Yasuo, Sonoda Shoji
Insect biochemistry and molecular biology, 2020年03月, 指定なし, 指定なし