Delayed inactivation of TRPC6 as a determinative characteristic of FSGS-associated variants.
Ryo Okada; Reiko Sakaguchi; Tatsuya Komaki; Ryu Nonaka; Onur K Polat; Takanori Kihara; Katsuhiko Asanuma; Takeshi Yamamoto; Yoshitaka Isaka; Yasuo Mori; Masayuki X Mori
The Journal of biological chemistry, Jun. 2025, Reviewed
Last, Corresponding

Dynamic remodeling of TRPC5 channel–caveolin-1–eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals
Reiko Sakaguchi; Nobuaki Takahashi; Takashi Yoshida; Nozomi Ogawa; Yoshifumi Ueda; Satoshi Hamano; Kaori Yamaguchi; Seishiro Sawamura; Shinichiro Yamamoto; Yuji Hara; Tomoya Kawamoto; Ryosuke Suzuki; Akito Nakao; Masayuki X. Mori; Tetsushi Furukawa; Shunichi Shimizu; Ryuji Inoue; Yasuo Mori
Journal of Biological Chemistry, Sep. 2024

新規選択的TRPC3/6チャネル阻害剤がラットPAN-誘導性蛋白尿の成分に与える影響
坂口 怜子; 松田 由宗; 岡田 亮; 石兼 真; 高橋 富美; 片渕 瑛介; 中山 敏幸; 眞田 賢哉; 上田 陽一; 永田 龍; 森 誠之
産業医科大学雑誌, Mar. 2023

Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation
Masayuki X. Mori; Ryo Okada; Reiko Sakaguchi; Hideharu Hase; Yuko Imai; Onur K. Polat; Satoru G. Itoh; Hisashi Okumura; Yasuo Mori; Yasushi Okamura; Ryuji Inoue
Scientific Reports, Dec. 2022

N-Methylamide-structured SB366791 derivatives with high TRPV1 antagonistic activity: toward PET radiotracers to visualize TRPV1
Tatsuya Kida; Nobuaki Takahashi; Masayuki X. Mori; Jiacheng H. Sun; Hideto Oota; Kosuke Nishino; Takashi Okauchi; Yuta Ochi; Daisuke Kano; Ukihide Tateishi; Yasuyoshi Watanabe; Yilong Cui; Yasuo Mori; Hisashi Doi
RSC Medicinal Chemistry, 2022

Extreme deformability of insect cell membranes is governed by phospholipid scrambling
Akifumi Shiomi; Kohjiro Nagao; Nobuhiro Yokota; Masaki Tsuchiya; Utako Kato; Naoto Juni; Yuji Hara; Masayuki X. Mori; Yasuo Mori; Kumiko Ui-Tei; Motohide Murate; Toshihide Kobayashi; Yuri Nishino; Atsuo Miyazawa; Akihisa Yamamoto; Ryo Suzuki; Stefan Kaufmann; Motomu Tanaka; Kazuya Tatsumi; Kazuyoshi Nakabe; Hirofumi Shintaku; Semen Yesylevsky; Mikhail Bogdanov; Masato Umeda
Cell Reports, Jun. 2021

Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis
Atsushi Masamune; Hiroshi Kotani; Franziska Lena Sörgel; Jian-Min Chen; Shin Hamada; Reiko Sakaguchi; Emmanuelle Masson; Eriko Nakano; Yoichi Kakuta; Tetsuya Niihori; Ryo Funayama; Matsuyuki Shirota; Tatsuya Hirano; Tetsuya Kawamoto; Atsuki Hosokoshi; Kiyoshi Kume; Lara Unger; Maren Ewers; Helmut Laumen; Peter Bugert; Masayuki X. Mori; Volodymyr Tsvilovskyy; Petra Weißgerber; Ulrich Kriebs; Claudia Fecher-Trost; Marc Freichel; Kalliope N. Diakopoulos; Alexandra Berninger; Marina Lesina; Kentaro Ishii; Takao Itoi; Tsukasa Ikeura; Kazuichi Okazaki; Tom Kaune; Jonas Rosendahl; Masao Nagasaki; Yasuhito Uezono; Hana Algül; Keiko Nakayama; Yoichi Matsubara; Yoko Aoki; Claude Férec; Yasuo Mori; Heiko Witt; Tooru Shimosegawa
Gastroenterology, May 2020

Engineering an enhanced voltage-sensing phosphatase
Akira Kawanabe; Natsuki Mizutani; Onur K Polat; Tomoko Yonezawa; Takafumi Kawai; Masayuki X Mori; Yasushi Okamura
The Journal of General Physiology, 2020, Reviewed, No invitation

Ryanodine receptor mutations (G4946E and I4790K) differentially responsible for diamide insecticide resistance in diamondback moth, Plutella xylostella L.
Jouraku A; Kuwazaki S; Miyamoto K; Uchiyama M; Kurokawa T; Mori E; Mori MX; Mori Y; Sonoda S
Insect biochemistry and molecular biology, Dec. 2019, Reviewed, No invitation

Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia
Daisuke Yamazaki; Ayaka Hasegawa; Yosuke Funato; Nam Tran Ha; Masayuki X. Mori; Yasuo Mori; Toshiro Sato; Hiroaki Miki
ONCOGENE, May 2019, Reviewed, No invitation

Contribution of Coiled-coil Assembly to Ca2+/Calmodulin-dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-associated Phenotypes
Polat, Onur; Uno, Masatoshi; Maruyama, Terukazu; Tran, Ha; Imamura, Kayo; Wong, Chee Fah; Sakaguchi, Reiko; Ariyoshi, Mariko; Kyohei , Itsuki; Ichikawa, Jun; Morii, Takashi; Shirakawa, Masahiro; Inoue, Ryuji; Asanuma, Katsuhiko; Reiser, Jochen; Tochio, Hidehito; Mori, Yasuo; Mori, Masayuki
Journal of the American Society of Nephrology, 2019, Reviewed, No invitation

ELKS/Voltage-Dependent Ca2+ Channel-beta Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic beta Cells
Mica Ohara-Imaizumi; Kyota Aoyagi; Hajime Yamauchi; Masashi Yoshida; Masayuki X. Mori; Yamato Hida; Ha Nam Tran; Masamichi Ohkura; Manabu Abe; Yoshihiro Akimoto; Yoko Nakamichi; Chiyono Nishiwaki; Hayato Kawakami; Kazuo Hara; Kenji Sakimura; Shinya Nagamatsu; Yasuo Mori; Junichi Nakai; Masafumi Kakei; Toshihisa Ohtsuka
CELL REPORTS, Jan. 2019, Reviewed, No invitation

Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation
Tsuchiya Masaki; Hara Yuji; Okuda Masaki; Itoh Karin; Nishioka Ryotaro; Shiomi Akifumi; Nagao Kohjiro; Mori Masayuki; Mori Yasuo; Ikenouchi Junichi; Suzuki Ryo; Tanaka Motomu; Ohwada Tomohiko; Aoki Junken; Kanagawa Motoi; Toda Tatsushi; Nagata Yosuke; Matsuda Ryoichi; Takayama Yasunori; Tominaga Makoto; Umeda Masato
NATURE COMMUNICATIONS, May 2018, Reviewed, No invitation

Ca2+-Dependent Inactivation Mediated by Calmodulin in TRPC6 Channel Underlies FSGS Channelopathy
Masatoshi Uno; Onur K. Polat; Ha Nam Tran; Shota Yamaji; Yasuo Mori; Hidehito Tochio; Masayuki X. Mori
BIOPHYSICAL JOURNAL, Feb. 2018, Not reviewed, No invitation

Functional Charaterization of Zebrafish Transient Receptor Potential Melastatin 2
Ha Nam Tran; Jure Hederih; Tomohiro Numata; Masayuki X. Mori; Shingo Maegawa; Hiroshi Hosokawa; Yasuo Mori
BIOPHYSICAL JOURNAL, Feb. 2018, Not reviewed, No invitation

Uncovering the arrhythmogenic potential of TRPM4 activation in atrial-derived HL-1 cells using novel recording and numerical approaches
Yaopeng Hu; Yubin Duan; Ayako Takeuchi; Lin Hai-Kurahara; Jun Ichikawa; Keizo Hiraishi; Tomohiro Numata; Hiroki Ohara; Gentaro Iribe; Michio Nakaya; Masayuki X. Mori; Satoshi Matsuoka; Genshan Ma; Ryuji Inoue
CARDIOVASCULAR RESEARCH, Aug. 2017

C-terminal splice variants of P/Q-type Ca2+ channel Ca(V)2.1 alpha(1) subunits are differentially regulated by Rab3-interacting molecule proteins
Mitsuru Hirano; Yoshinori Takada; Chee Fah Wong; Kazuma Yamaguchi; Hiroshi Kotani; Tatsuki Kurokawa; Masayuki X. Mori; Terrance P. Snutch; Michel Ronjat; Michel De Waard; Yasuo Mori
JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2017, Reviewed, No invitation

Calmodulin and ATP support activity of the Cav1.2 channel through dynamic interactions with the channel
Etsuko Minobe; Masayuki X. Mori; Masaki Kameyama
JOURNAL OF PHYSIOLOGY-LONDON, Apr. 2017, Reviewed, No invitation

Multi-point interaction between P/Q-type voltage-dependent Ca2+ channel and alpha-RIMs augments RIMs suppressive effect on voltage dependent inactivation
Mitsuru Hirano; Kazuma Yamaguchi; Yoshinori Takada; Takeshi Kotani; Tatsuki Kurokawa; Masayuki. X. Mori; Yasuo Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2017, Not reviewed, No invitation

FUNCTIONAL CHARATERIZATION OF ZEBRAFISH TRANSIENT RECEPTOR POTENTIAL MELASTATIN 2 IN HEK 293 CELL LINE
Ha Nam Tran; Tomohiro Numata; Masayuki X. Mori; Shingo Maegawa; Hiroshi Hosokawa; Shingo Tanaka; Yasuo Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2017, Not reviewed, No invitation

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds
Sawamura S; Hatano M; Takada Y; Hino K; Kawamura T; Tanikawa J; Nakagawa H; Hase H; Nakao A; Hirano M; Rotrattanadumrong R; Kiyonaka S; Mori MX; Nishida M; Hu Y; Inoue R; Nagata R; Mori Y
Mol Pharmacol., 2016, Reviewed, No invitation

Post-transcriptional modifications and "Calmodulation" of voltage-gated calcium channel function: Reflections by two collaborators of David T Yue
Tuck Wah Soong; Masayuki X. Mori
CHANNELS, Jan. 2016, Reviewed, Invited

Rab3 interacting molecule 3 mutations associated with autism alter regulation of voltage-dependent Ca2+ channels
Yoshinori Takada; Mitsuru Hirano; Shigeki Kiyonaka; Yoshifumi Ueda; Kazuma Yamaguchi; Keiko Nakahara; Masayuki X. Mori; Yasuo Mori
CELL CALCIUM, Sep. 2015, Reviewed, No invitation

Dynamics of receptor-operated Ca2+ currents through TRPC channels controlled via the PI(4,5),P-2-PLC signaling pathway
Masayuki X. Mori; Kyohei Itsuki; Hideharu Hese; Seishiro Sawamura; Tatsuki Kurokawa; Yasuo Mori; Ryuji Inoue
FRONTIERS IN PHARMACOLOGY, Feb. 2015, Reviewed, Invited

New Experimental Trends for Phosphoinositides Research on Ion Transporter/Channel Regulation
Masayuki X. Mori; Ryuji Inoue
JOURNAL OF PHARMACOLOGICAL SCIENCES, Nov. 2014, Reviewed, Invited

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P-2
Nobuaki Takahashi; Sayaka Hamada-Nakahara; Yuzuru Itoh; Kazuhiro Takemura; Atsushi Shimada; Yoshifumi Ueda; Manabu Kitamata; Rei Matsuoka; Kyoko Hanawa-Suetsugu; Yosuke Senju; Masayuki X. Mori; Shigeki Kiyonaka; Daisuke Kohda; Akio Kitao; Yasuo Mori; Shiro Suetsugu
NATURE COMMUNICATIONS, Sep. 2014, Reviewed, No invitation

Bridge between the channel and FRET of PtdIns(4,5)P-2 sensor
Masayuki X. Mori
CHANNELS, Jul. 2014, Reviewed, Invited

PLC-mediated PI(4,5)P-2 hydrolysis regulates activation and inactivation of TRPC6/7 channels
Kyohei Itsuki; Yuko Imai; Hideharu Hase; Yasushi Okamura; Ryuji Inoue; Masayuki X. Mori
JOURNAL OF GENERAL PHYSIOLOGY, Feb. 2014, Reviewed, No invitation

A human Dravet syndrome model from patient induced pluripotent stem cells
Norimichi Higurashi; Taku Uchida; Christoph Lossin; Yoshio Misumi; Yohei Okada; Wado Akamatsu; Yoichi Imaizumi; Bo Zhang; Kazuki Nabeshima; Masayuki X. Mori; Shutaro Katsurabayashi; Yukiyoshi Shirasaka; Hideyuki Okano; Shinichi Hirose
MOLECULAR BRAIN, May 2013, Reviewed, No invitation

Voltage-sensing phosphatase reveals temporal regulation of TRPC3/C6/C7 channels by membrane phosphoinositides
Kyohei Itsuki; Yuko Imai; Yasushi Okamura; Kihachiro Abe; Ryuji Inoue; Masayuki X. Mori
CHANNELS, May 2012, Reviewed, No invitation

A self-limiting regulation of vasoconstrictor-activated TRPC3/C6/C7 channels coupled to PI(4,5)P2-diacylglycerol signalling
Yuko Imai; Kyohei Itsuki; Yasushi Okamura; Ryuji Inoue; Masayuki X. Mori
JOURNAL OF PHYSIOLOGY-LONDON, Feb. 2012, Reviewed, No invitation

Quantitative Measurement of Ca2+-Dependent Calmodulin-Target Binding by Fura-2 and CFP and YFP FRET Imaging in Living Cells
Masayuki X. Mori; Yuko Imai; Kyohei Itsuki; Ryuji Inoue
BIOCHEMISTRY, May 2011, Reviewed, No invitation

Chemical-mechanical synergism for cardiovascular TRPC6 channel activation via PLC/diacylglycerol and PLA2/omega-hydroxylase/20-HETE pathways.
Inoue R; Mori M; Kawarabayashi Y; Jian Z
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Sep. 2009, Reviewed, No invitation

心血管TRPチャネルを巡る病態生理の新展開
井上隆司; 瓦林精広; 森誠之
日本心電図学会誌(Jpn. J. Electrocardiology, 2009, Not reviewed, No invitation

Recepto-mechanical synergism in activation of vascular receptor-operated Ca²⁺ channel TRPC6
Inoue Ryuji; Kawarabayashi Yasuhiro; Takahashi Shinichi; Hai Lin; Mori Masayuki; Honda Akira
Proceedings of Annual Meeting of the Physiological Society of Japan, 2008

Stable expression and characterization of human PN1 and PN3 sodium channels
Akiba, I; T Seki; M Mori; M Iizuka; S Nishimura; S Sasaki; K Imoto; EL Barsoumian
RECEPTORS & CHANNELS, Sep. 2003, Reviewed, No invitation

蛋白尿改善を目指したイオンチャネル阻害剤の開発と評価
坂口怜子, 松田由宗, 岡田亮, 石兼真, 高橋富美, 片渕瑛介, 中山敏幸, 眞田賢哉 上田陽一, 木原隆典, 永田龍, 森誠之
Journal of UOEH, Mar. 2024, Reviewed, Null
Last

生化学・分子生物学　腎変性"FSGS"の発症を抑制するTRPC6のカルシウム依存的不活性化機構(CDI)
森 誠之, 岡田 亮
医学のあゆみ, Jul. 2020, Not reviewed, Invited
Lead

Novel interaction of the voltage-dependent sodium channel (VDSC) with calmodulin: does VDSC acquire calmodulin-mediated Ca2+-sensitivity?
Takashi Konno, Takeaki Ozawa, Masayuki Murata, Keiji Imoto, Kuniaki Nagayama
Biochemistry, Mar. 2000, Reviewed, No invitation
Lead

ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells.
Ohara-Imaizumi M1, Aoyagi K2, Yamauchi H3, Yoshida M4, Mori MX5, Hida Y3, Tran HN6, Ohkura M7, Abe M8, Akimoto Y9, Nakamichi Y2, Nishiwaki C2, Kawakami H9, Hara K4, Sakimura K10, Nagamatsu S11, Mori Y12, Nakai J7, Kakei M4, Ohtsuka T13.
Cell reports (Cambridge), Jan. 2019, Reviewed, Null

Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis.
Masamune Atsushi, Kotani Hiroshi, Sörgel Franziska Lena, Chen Jian-Min, Hamada Shin, Sakaguchi Reiko, Masson Emmanuelle, Nakano Eriko, Kakuta Yoichi, Niihori Tetsuya, Funayama Ryo, Shirota Matsuyuki, Hirano Tatsuya, Kawamoto Tetsuya, Hosokoshi Atsuki, Kume Kiyoshi, Unger Lara, Ewers Maren, Laumen Helmut, Bugert Peter, Mori Masayuki X, Tsvilovskyy Volodymyr, Weißgerber Petra, Kriebs Ulrich, Fecher-Trost Claudia, Freichel Marc, Diakopoulos Kalliope N, Berninger Alexandra, Lesina Marina, Ishii Kentaro, Itoi Takao, Ikeura Tsukasa, Okazaki Kazuichi, Kaune Tom, Rosendahl Jonas, Nagasaki Masao, Uezono Yasuhito, Algül Hana, Nakayama Keiko, Matsubara Yoichi, Aoki Yoko, Férec Claude, Mori Yasuo, Witt Heiko, Shimosegawa Tooru
Gastroenterology, May 2020, Reviewed, Null

Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals.
Reiko Sakaguchi,Nobuaki Takahashi,Takashi Yoshida,Nozomi Ogawa,Yoshifumi Ueda,Satoshi Hamano,Kaori Yamaguchi,Seishiro Sawamura,Shinichiro Yamamoto,Yuji Hara,Tomoya Kawamoto,Ryosuke Suzuki,Akito Nakao,Masayuki X Mori,Tetsushi Furukawa,Shunichi Shimizu,Ryuji Inoue,Yasuo Mori
The Journal of biological chemistry, Aug. 2024, Reviewed, No invitation

Delayed inactivation of TRPC6 as a determinative characteristic of FSGS-associated variants.
Okada Ryo, Sakaguchi Reiko, Komaki Tatsuya, Nonaka Ryu, Polat Onur K, Kihara Takanori, Asanuma Katsuhiko, Yamamoto Takeshi, Isaka Yoshitaka, Mori Yasuo, Mori Masayuki X
The Journal of biological chemistry, May 2025, Reviewed, Null
Last, Corresponding

Engineering an enhanced voltage-sensing phosphatase.
Kawanabe Akira, Mizutani Natsuki, Polat Onur K, Yonezawa Tomoko, Kawai Takafumi, Mori Masayuki X, Okamura Yasushi
The Journal of general physiology, May 2020, Reviewed, Invited

Contribution of Coiled-Coil Assembly to Ca2+/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes.
Polat Onur K, Uno Masatoshi, Maruyama Terukazu, Tran Ha Nam, Imamura Kayo, Wong Chee Fah, Sakaguchi Reiko, Ariyoshi Mariko, Itsuki Kyohei, Ichikawa Jun, Morii Takashi, Shirakawa Masahiro, Inoue Ryuji, Asanuma Katsuhiko, Reiser Jochen, Tochio Hidehito, Mori Yasuo, Mori Masayuki X
Journal of the American Society of Nephrology : JASN, Jul. 2019, Reviewed, Null
Corresponding

Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia.
Yamazaki Daisuke, Hasegawa Ayaka, Funato Yosuke, Tran Ha Nam, Mori Masayuki X, Mori Yasuo, Sato Toshiro, Miki Hiroaki
Oncogene, May 2019, Reviewed, Null

Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation.
Mori Masayuki X, Okada Ryo, Sakaguchi Reiko, Hase Hideharu, Imai Yuko, Polat Onur K, Itoh Satoru G, Okumura Hisashi, Mori Yasuo, Okamura Yasushi, Inoue Ryuji
Scientific reports, Jun. 2022, Reviewed, No invitation
Lead

Extreme deformability of insect cell membranes is governed by phospholipid scrambling.
Shiomi Akifumi, Nagao Kohjiro, Yokota Nobuhiro, Tsuchiya Masaki, Kato Utako, Juni Naoto, Hara Yuji, Mori Masayuki X, Mori Yasuo, Ui-Tei Kumiko, Murate Motohide, Kobayashi Toshihide, Nishino Yuri, Miyazawa Atsuo, Yamamoto Akihisa, Suzuki Ryo, Kaufmann Stefan, Tanaka Motomu, Tatsumi Kazuya, Nakabe Kazuyoshi, Shintaku Hirofumi, Yesylevsky Semen, Bogdanov Mikhail, Umeda Masato
Cell reports, Jun. 2021, Null, Invited

Ryanodine receptor mutations (G4946E and I4790K) differentially responsible for diamide insecticide resistance in diamondback moth, Plutella xylostella L.
Jouraku Akiya, Kuwazaki Seigo, Miyamoto Kazuhisa, Uchiyama Makoto, Kurokawa Tatsuki, Mori Emiko, Mori Masayuki X, Mori Yasuo, Sonoda Shoji
Insect biochemistry and molecular biology, Mar. 2020, Null, Null

“イオンチャネル・受容体の構造機能連関研究の新たな潮流” “カルモジュリンによる電位依存性Caチャネルのフィードバック制御” 細胞工学
2006, Not reviewed