Targeting mitochondrial metabolism for the treatment of acute myeloid leukemia (AML)
齋藤祐介
日本小児血液・がん学会雑誌(Web), 2025
Lead, Corresponding

Mitochondrial dynamics as a potential therapeutic target in acute myeloid leukemia.
Mariko Kinoshita; Yusuke Saito; Kento Otani; Yuya Uehara; Shun Nagasawa; Midori Nakagawa; Ai Yamada; Sachiyo Kamimura; Hiroshi Moritake
International journal of hematology, Nov. 2024

The CGRP Receptor Antagonist MK0974 Induces EVI1high AML Cell Apoptosis by Disrupting ERK Signaling.
Akira Suekane; Tomonaga Ichikawa; Yusuke Saito; Shingo Nakahata; Kazuhiro Morishita
Anticancer research, Oct. 2022

Kikuchi-Fujimoto Disease Following COVID-19 Infection in a 7-Year-Old Girl: A Case Report and Literature Review.
Yusuke Saito; Yuta Suwa; Yakuto Kaneko; Mitsuhiro Tsujiwaki; Yasuhisa Odagawa
Cureus, Jul. 2022

GHS-R1a deficiency mitigates lipopolysaccharide-induced lung injury in mice via the downregulation of macrophage activity.
Ryota Tanida; Hironobu Tsubouchi; Shigehisa Yanagi; Yusuke Saito; Koji Toshinai; Taiga Miyazaki; Toshinari Takamura; Masamitsu Nakazato
Biochemical and biophysical research communications, Jan. 2022

Successful treatment with rituximab for autoimmune cytopenia after autologous hematopoietic stem cell transplantation.
Mariko Kinoshita; Ai Yamada; Yusuke Saito; Sachiyo Kamimura; Hiroshi Moritake
Pediatrics international : official journal of the Japan Pediatric Society, Jan. 2022

Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia.
Yusuke Saito; Mariko Kinoshita; Ai Yamada; Sayaka Kawano; Hong-Shan Liu; Sachiyo Kamimura; Midori Nakagawa; Syun Nagasawa; Tadao Taguchi; Shuhei Yamada; Hiroshi Moritake
Cancer science, Dec. 2021

Malignant perivascular epithelioid cell neoplasm in the liver: report of a pediatric case.
Tokuro Baba; Takafumi Kawano; Yusuke Saito; Shun Onishi; Koji Yamada; Waka Yamada; Ryuta Masuya; Kazuhiko Nakame; Yota Kawasaki; Satoshi Iino; Masahiko Sakoda; Mari Kirishima; Tatsuru Kaji; Akihide Tanimoto; Shoji Natsugoe; Takao Ohtsuka; Hiroshi Moritake; Satoshi Ieiri
Surgical case reports, Sep. 2021

Intracellular glutamine level determines vascular smooth muscle cell-derived thrombogenicity.
Shohei Koyama; Atsushi Yamashita; Yunosuke Matsuura; Yusuke Saito; Kazunari Maekawa; Toshihiro Gi; Kazuo Kitamura; Yujiro Asada
Atherosclerosis, Jul. 2021

A useful method to diagnose Pearson syndrome mimicking Diamond-Blackfan anemia.
Toyoki Nishimura; Ai Yamada; Maiko Utoyama; Yusuke Saito; Hiroshi Moritake
Pediatrics international : official journal of the Japan Pediatric Society, Feb. 2021

ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue.
Hironori Kato; Kohki Okabe; Masato Miyake; Kazuki Hattori; Tomohiro Fukaya; Kousuke Tanimoto; Shi Beini; Mariko Mizuguchi; Satoru Torii; Satoko Arakawa; Masaya Ono; Yusuke Saito; Takashi Sugiyama; Takashi Funatsu; Katsuaki Sato; Shigeomi Shimizu; Seiichi Oyadomari; Hidenori Ichijo; Hisae Kadowaki; Hideki Nishitoh
Life science alliance, Mar. 2020, Reviewed, No invitation

TAE226, a dual inhibitor of focal adhesion kinase and insulin-like growth factor-I receptor, is effective for Ewing sarcoma.
Hiroshi Moritake; Yusuke Saito; Daisuke Sawa; Naoki Sameshima; Ai Yamada; Mariko Kinoshita; Sachiyo Kamimura; Takao Konomoto; Hiroyuki Nunoi
Cancer medicine, Dec. 2019, Reviewed, No invitation

EVI1 triggers metabolic reprogramming associated with leukemogenesis and increases sensitivity to L-asparaginase.
Yusuke Saito; Daisuke Sawa; Mariko Kinoshita; Ai Yamada; Sachiyo Kamimura; Akira Suekane; Honami Ogoh; Hidemasa Matsuo; Souichi Adachi; Takashi Taga; Daisuke Tomizawa; Motomi Osato; Tomoyoshi Soga; Kazuhiro Morishita; Hiroshi Moritake
Haematologica, Oct. 2019, Reviewed, No invitation

PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia-initiating cells.
Tianyuan Hu; Kiyomi Morita; Matthew C Hill; Yajian Jiang; Ayumi Kitano; Yusuke Saito; Feng Wang; Xizeng Mao; Kevin A Hoegenauer; Kazuhiro Morishita; James F Martin; P Andrew Futreal; Koichi Takahashi; Daisuke Nakada
Blood, Aug. 2019, Reviewed, No invitation

Long-term Remission of Acute Myeloid Leukemia Developed From Systemic Mastocytosis by Conventional Chemotherapy.
Ai Yamada; Mariko Kinoshita; Daisuke Sawa; Yusuke Saito; Sachiyo Kamimura; Hayato Miyachi; Hiroshi Moritake
Journal of pediatric hematology/oncology, Aug. 2019, Reviewed, No invitation

CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis.
Akira Suekane; Yusuke Saito; Shingo Nakahata; Tomonaga Ichikawa; Honami Ogoh; Kazutake Tsujikawa; Kazuhiro Morishita
Scientific reports, Jan. 2019, Reviewed, No invitation

[Acute myeloid leukemia evolving from KIT D816-mutated systemic mastocytosis relapsing two months after completion of chemotherapy].
Takuro Harao; Ai Yamada; Mariko Kinoshita; Daisuke Sawa; Yusuke Saito; Sachiyo Kamimura; Hayato Miyachi; Takashi Ogino; Yuichi Kodama; Yasuhiro Okamoto; Yoshifumi Kawano; Hiroshi Moritake
[Rinsho ketsueki] The Japanese journal of clinical hematology, 2019, Reviewed, No invitation

Haploinsufficiency of SNX13 contributes to leukemogenesis as a responsive gene for monosomy 7 in EVI1 high AML
Ogoh Honami; Suekane Akira; Saito Yusuke; Kaneda Kazuko; Nawin Manachai; Morishita Kazuhiro
CANCER SCIENCE, Dec. 2018, Reviewed, No invitation

CGRP-CRLR/RAMP1 signal regulated by EVI1 promotes leukemogenesis
Suekane Akira; Saito Yusuke; Nakahata Shingo; Ogoh Honami; Ichikawa Tomonaga; Nawin Manachai; Matin Juliana Farha; Kaneda Kazuko; Osato Motomi; Morishita Kazuhiro
CANCER SCIENCE, Dec. 2018, Reviewed, No invitation

EVI1 in Acute Myeloid Leukemia Triggers Metabolic Reprograming Associated with Leukemogenesis and Increases Sensitivity to L-Aspalaginase
Saito Yusuke; Sawa Daisuke; Kinoshita Mariko; Yamada Ai; Kamimura Sachiyo; Morishita Kazuhiro; Soga Tomoyoshi; Moritake Hiroshi
BLOOD, Nov. 2018, Reviewed, No invitation

Suppression of GPR56 expression by pyrrole-imidazole polyamide represents a novel therapeutic drug for AML with high EVI1 expression.
Hasi Rani Saha; Kazuko Kaneda-Nakashima; Shunsuke Shimosaki; Akira Suekane; Bidhan Sarkar; Yusuke Saito; Honami Ogoh; Shingo Nakahata; Kentaro Inoue; Takayoshi Watanabe; Hiroki Nagase; Kazuhiro Morishita
Scientific reports, Sep. 2018, Reviewed, No invitation

CGRP-CRLR/RAMP1シグナルはストレス造血において重要である(CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis)
末金 彰; 齋藤 祐介; 中畑 新吾; 市川 朝永; 小河 穂波; 辻川 和丈; 森下 和広
臨床血液, Sep. 2018

SNX13のハプロ不全はEVI1高発現AMLのmonosomy 7における原因遺伝子として白血病化に寄与している(Haploinsufficiency of SNX13 contributes to leukemogenesis as a responsive gene for monosomy 7 in EVI1 high AML)
小河 穂波; 末金 彰; 齋藤 祐介; 兼田 加珠子; ナーウィン・マナチャイ; 森下 和広
日本癌学会総会記事, Sep. 2018

Short-form of BCL11B contributes to tumorigenesis of adult T-cell leukemia/lymphoma
Permatasari Happy; Nakahata Shingo; Ichikawa Tomonaga; Saito Yusuke; Taki Tomohiko; Taniwaki Masafumi; Morishita Kazuhiro
CANCER SCIENCE, Jan. 2018, Reviewed, No invitation

Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages
Y. Komohara; C. Ma; H. Yano; C. Pan; H. Horlad; Y. Saito; K. Ohnishi; Y. Fujiwara; Y. Okuno; K. Nosaka; S. Shimosaki; K. Morishita; M. Matsuoka; T. Wakayama; M. Takeya
J Clin Exp Hematop., Jul. 2017, Reviewed, No invitation

A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin.
Hiroshi Moritake; Megumi Obara; Yusuke Saito; Ayako Kashimada; Masatoshi Takagi; Megumi Funakoshi-Tago; Tomofusa Fukuyama; Mikio Yoshioka; Akira Inoue; Hiroyuki Komatsu; Hideki Nishitoh; Hiroaki Kataoka; Hiroyuki Nunoi
Human cell, Apr. 2017, Reviewed, No invitation

Activation of EVI1 transcription by the LEF1/β-catenin complex with p53-alteration in myeloid blast crisis of chronic myeloid leukemia.
Nawin Manachai; Yusuke Saito; Shingo Nakahata; Avinash Govind Bahirvani; Motomi Osato; Kazuhiro Morishita
Biochemical and biophysical research communications, Jan. 2017, Reviewed, No invitation

Ghrelin does not influence cancer progression in a lung adenocarcinoma cell line.
Hironobu Tsubouchi; Hitomi Onomura; Yusuke Saito; Shigehisa Yanagi; Ayako Miura; Ayako Matsuo; Nobuhiro Matsumoto; Masamitsu Nakazato
Endocrine journal, 2017, Reviewed, No invitation

EVI1高発現急性骨髄性白血病における神経因性ペプチドシグナル
末金 彰; 齋藤 祐介; 森下 和広
日本癌学会総会記事, Oct. 2016

AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow.
Yusuke Saito; Richard H Chapple; Angelique Lin; Ayumi Kitano; Daisuke Nakada
Cell stem cell, Nov. 2015, Reviewed, No invitation

GPR56とCD52はEVI1高発現白血病の新たな治療標的分子である(GPR56 and CD52 as a new molecular target of acute myeloid leukemia with high EVI1 expression)
齋藤 祐介; 兼田 加珠子; 下崎 俊介; 末金 彰; 森下 和広
日本小児血液・がん学会雑誌, Oct. 2015

INHIBITION OF GPR56 BY PI-POLYAMIDE TARGETING THE EVI1-BINDING SITE WITH SUPPRESSION OF LEUKEMIA
Kaneda Kazuko N; Saito Yusuke; Suekane Akira; Shimosaki Shunsuke; Morishita Kazuhiro
EXPERIMENTAL HEMATOLOGY, Sep. 2015, Reviewed, No invitation

DOWN-REGULATION OF NDRG2 PLAYS AN IMPORTANT ROLE IN ATLL LEUKEMOGENESIS VIA THE PTEN-MEDIATED PI3K/AKT SIGNALING PATHWAY
Nakahata Shingo; Ichikawa Tomonaga; Yusuke Saito; Arai Yasuhito; Taki Tomohiko; Taniwaki Masafumi; Morishita Kazuhiro
EXPERIMENTAL HEMATOLOGY, Sep. 2015, Reviewed, No invitation

[Maintenance of leukemic and normal hematopoietic stem cells in bone marrow niches by EVI1-regulated GPR56].
Yusuke Saito; Kazuhiro Morishita
[Rinsho ketsueki] The Japanese journal of clinical hematology, Apr. 2015, Reviewed, No invitation

Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.
Shingo Nakahata; Tomonaga Ichikawa; Phudit Maneesaay; Yusuke Saito; Kentaro Nagai; Tomohiro Tamura; Nawin Manachai; Norio Yamakawa; Makoto Hamasaki; Issay Kitabayashi; Yasuhito Arai; Yae Kanai; Tomohiko Taki; Takaya Abe; Hiroshi Kiyonari; Kazuya Shimoda; Koichi Ohshima; Akira Horii; Hiroshi Shima; Masafumi Taniwaki; Ryoji Yamaguchi; Kazuhiro Morishita
Nature communications, Feb. 2014, Reviewed, No invitation

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.
Daisuke Nakada; Hideyuki Oguro; Boaz P Levi; Nicole Ryan; Ayumi Kitano; Yusuke Saitoh; Makiko Takeichi; George R Wendt; Sean J Morrison
Nature, Jan. 2014, Reviewed, No invitation

The role of the Lkb1/AMPK pathway in hematopoietic stem cells and Leukemia.
Yusuke Saito; Daisuke Nakada
Critical reviews in oncogenesis, 2014, Reviewed, No invitation

AMLに対するインテグリン中和抗体の治療効果に関する検討(Investigation of therapeutic efficacy of neutralizing antibody of integrin for AML)
兼田 加珠子[中島]; 末金 彰; 斎藤 祐介; 山川 哲生; 黒澤 仁; 森下 和広
日本癌学会総会記事, Oct. 2013

Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56.
Y Saito; K Kaneda; A Suekane; E Ichihara; S Nakahata; N Yamakawa; K Nagai; N Mizuno; K Kogawa; I Miura; H Itoh; K Morishita
Leukemia, Aug. 2013, Reviewed, No invitation

Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma.
S Nakahata; Y Saito; K Marutsuka; T Hidaka; K Maeda; K Hatakeyama; T Shiraga; A Goto; N Takamatsu; Y Asada; A Utsunomiya; A Okayama; Y Kubuki; K Shimoda; Y Ukai; G Kurosawa; K Morishita
Leukemia, Jun. 2012, Reviewed, No invitation

Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation.
Yuudai Kondo; Kentaro Nagai; Shingo Nakahata; Yusuke Saito; Tomonaga Ichikawa; Akira Suekane; Tomohiko Taki; Reika Iwakawa; Masato Enari; Masafumi Taniwaki; Jun Yokota; Sumio Sakoda; Kazuhiro Morishita
Cancer science, Apr. 2012, Reviewed, No invitation

The increased expression of integrin α6 (ITGA6) enhances drug resistance in EVI1(high) leukemia.
Norio Yamakawa; Kazuko Kaneda; Yusuke Saito; Emi Ichihara; Kazuhiro Morishita
PloS one, 2012, Reviewed, No invitation

Angiopoietin1 contributes to the maintenance of cell quiescence in EVI1(high) leukemia cells.
Emi Ichihara; Kazuko Kaneda; Yusuke Saito; Norio Yamakawa; Kazuhiro Morishita
Biochemical and biophysical research communications, Dec. 2011, Reviewed, No invitation

Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation
I. Nishikata; S. Nakahata; Y. Saito; K. Kaneda; E. Ichihara; N. Yamakawa; K. Morishita
ONCOGENE, Oct. 2011, Reviewed, No invitation

CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression.
Y Saito; S Nakahata; N Yamakawa; K Kaneda; E Ichihara; A Suekane; K Morishita
Leukemia, Jun. 2011, Reviewed, No invitation

成人T細胞白血病細胞におけるCDKN1A遺伝子の転写はプロモーターのメチル化とZEB1発現低下により抑制される
中畑 新吾; 渡邊 正明; 浜崎 誠; 斎藤 祐介; 河野 洋平; 森下 和広
臨床血液, Sep. 2010

Downregulation of CDKN1A in adult T-cell leukemia/lymphoma despite overexpression of CDKN1A in human T-lymphotropic virus 1-infected cell lines.
Masaaki Watanabe; Shingo Nakahata; Makoto Hamasaki; Yusuke Saito; Yohei Kawano; Tomonori Hidaka; Kiyoshi Yamashita; Kazumi Umeki; Tomohiko Taki; Masafumi Taniwaki; Akihiko Okayama; Kazuhiro Morishita
Journal of virology, Jul. 2010, Reviewed, No invitation

Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma.
Shingo Nakahata; Yusuke Saito; Makoto Hamasaki; Tomonori Hidaka; Yasuhito Arai; Tomohiko Taki; Masafumi Taniwaki; Kazuhiro Morishita
Genes, chromosomes & cancer, Sep. 2009, Reviewed, No invitation

NDRG2は成人T細胞白血病のがん抑制遺伝子候補である(NDRG2 is a candidate tumor suppressor gene in adult-T cell leukemia/lymphoma)
濱崎 誠; 中畑 信吾; 斎藤 祐介; 河野 洋平; 新井 康仁; 滝 智彦; 谷脇 雅史; 森下 和広
日本癌学会総会記事, Aug. 2009

Long-term survival after autologous peripheral blood stem cell transplantation in two patients with malignant rhabdoid tumor of the kidney.
Yuhki Koga; Akinobu Matsuzaki; Aiko Suminoe; Miho Hatano; Yusuke Saito; Yoshiaki Kinoshita; Tatsuro Tajiri; Tomoaki Taguchi; Kenichi Kohashi; Yoshinao Oda; Masazumi Tsuneyoshi; Toshiro Hara
Pediatric blood & cancer, Jul. 2009, Reviewed, No invitation

Congenital Ewing sarcoma in retroperitoneum with multiple metastases.
Yusuke Saito; Akinobu Matsuzaki; Aiko Suminoe; Yuhki Koga; Hiroaki Kurata; Yoshinao Oda; Masazumi Tsuneyoshi; Toshiro Hara
Pediatric blood & cancer, Nov. 2008, Reviewed, No invitation

[Alveolar rhabdomyosarcoma of unknown origin mimicking acute leukemia at the initial presentation].
Kan Yamaguchi; Yuhki Koga; Aiko Suminoe; Yusuke Saito; Akinobu Matsuzaki; Shunsuke Kanno; Tomohito Takimoto; Masahiro Suda; Yoshinao Oda; Toshitaka Muto; Hiroshi Takatsuki; Toshiro Hara
[Rinsho ketsueki] The Japanese journal of clinical hematology, Apr. 2007

Bone marrow transplantation in children with severe aplastic anemia using a conditioning regimen containing 3 Gy of total body irradiation, cyclophosphamide with or without antithymocyte globulin.
Jiro Inagaki; Yoshihisa Nagatoshi; Yoshifumi Kawano; Yusuke Saito; Daijiro Takahashi; Jun Nagayama; Yuichi Shinkoda; Hideki Hirata; Jun Okamura
Pediatric transplantation, Mar. 2007

Successful umbilical cord blood transplantation for severe chronic active Epstein-Barr virus infection after the double failure of hematopoietic stem cell transplantation.
Masataka Ishimura; Shouichi Ohga; Akihiko Nomura; Taikai Toubo; Eiji Morihana; Yusuke Saito; Hisanori Nishio; Makoto Ide; Hidetoshi Takada; Toshiro Hara
American journal of hematology, Nov. 2005, Reviewed, No invitation

Bronchiolitis obliterans organizing pneumonia as an initial manifestation in systemic lupus erythematosus.
Hidetoshi Takada; Yusuke Saito; Akihiko Nomura; Shouichi Ohga; Kazuyoshi Kuwano; Nobutaka Nakashima; Shinichi Aishima; Noboru Tsuru; Toshiro Hara
Pediatric pulmonology, Sep. 2005, Reviewed, No invitation