ミトコンドリア代謝を標的としたAML治療
齋藤祐介
日本小児血液・がん学会雑誌(Web), 2025年
筆頭著者, 責任著者

Mitochondrial dynamics as a potential therapeutic target in acute myeloid leukemia.
Mariko Kinoshita; Yusuke Saito; Kento Otani; Yuya Uehara; Shun Nagasawa; Midori Nakagawa; Ai Yamada; Sachiyo Kamimura; Hiroshi Moritake
International journal of hematology, 2024年11月

The CGRP Receptor Antagonist MK0974 Induces EVI1high AML Cell Apoptosis by Disrupting ERK Signaling.
Akira Suekane; Tomonaga Ichikawa; Yusuke Saito; Shingo Nakahata; Kazuhiro Morishita
Anticancer research, 2022年10月

Kikuchi-Fujimoto Disease Following COVID-19 Infection in a 7-Year-Old Girl: A Case Report and Literature Review.
Yusuke Saito; Yuta Suwa; Yakuto Kaneko; Mitsuhiro Tsujiwaki; Yasuhisa Odagawa
Cureus, 2022年07月

GHS-R1a deficiency mitigates lipopolysaccharide-induced lung injury in mice via the downregulation of macrophage activity.
Ryota Tanida; Hironobu Tsubouchi; Shigehisa Yanagi; Yusuke Saito; Koji Toshinai; Taiga Miyazaki; Toshinari Takamura; Masamitsu Nakazato
Biochemical and biophysical research communications, 2022年01月

Successful treatment with rituximab for autoimmune cytopenia after autologous hematopoietic stem cell transplantation.
Mariko Kinoshita; Ai Yamada; Yusuke Saito; Sachiyo Kamimura; Hiroshi Moritake
Pediatrics international : official journal of the Japan Pediatric Society, 2022年01月

Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia.
Yusuke Saito; Mariko Kinoshita; Ai Yamada; Sayaka Kawano; Hong-Shan Liu; Sachiyo Kamimura; Midori Nakagawa; Syun Nagasawa; Tadao Taguchi; Shuhei Yamada; Hiroshi Moritake
Cancer science, 2021年12月

Malignant perivascular epithelioid cell neoplasm in the liver: report of a pediatric case.
Tokuro Baba; Takafumi Kawano; Yusuke Saito; Shun Onishi; Koji Yamada; Waka Yamada; Ryuta Masuya; Kazuhiko Nakame; Yota Kawasaki; Satoshi Iino; Masahiko Sakoda; Mari Kirishima; Tatsuru Kaji; Akihide Tanimoto; Shoji Natsugoe; Takao Ohtsuka; Hiroshi Moritake; Satoshi Ieiri
Surgical case reports, 2021年09月

Intracellular glutamine level determines vascular smooth muscle cell-derived thrombogenicity.
Shohei Koyama; Atsushi Yamashita; Yunosuke Matsuura; Yusuke Saito; Kazunari Maekawa; Toshihiro Gi; Kazuo Kitamura; Yujiro Asada
Atherosclerosis, 2021年07月

A useful method to diagnose Pearson syndrome mimicking Diamond-Blackfan anemia.
Toyoki Nishimura; Ai Yamada; Maiko Utoyama; Yusuke Saito; Hiroshi Moritake
Pediatrics international : official journal of the Japan Pediatric Society, 2021年02月

ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue.
Hironori Kato; Kohki Okabe; Masato Miyake; Kazuki Hattori; Tomohiro Fukaya; Kousuke Tanimoto; Shi Beini; Mariko Mizuguchi; Satoru Torii; Satoko Arakawa; Masaya Ono; Yusuke Saito; Takashi Sugiyama; Takashi Funatsu; Katsuaki Sato; Shigeomi Shimizu; Seiichi Oyadomari; Hidenori Ichijo; Hisae Kadowaki; Hideki Nishitoh
Life science alliance, 2020年03月, 査読あり, 招待無し

TAE226, a dual inhibitor of focal adhesion kinase and insulin-like growth factor-I receptor, is effective for Ewing sarcoma.
Hiroshi Moritake; Yusuke Saito; Daisuke Sawa; Naoki Sameshima; Ai Yamada; Mariko Kinoshita; Sachiyo Kamimura; Takao Konomoto; Hiroyuki Nunoi
Cancer medicine, 2019年12月, 査読あり, 招待無し

EVI1 triggers metabolic reprogramming associated with leukemogenesis and increases sensitivity to L-asparaginase.
Yusuke Saito; Daisuke Sawa; Mariko Kinoshita; Ai Yamada; Sachiyo Kamimura; Akira Suekane; Honami Ogoh; Hidemasa Matsuo; Souichi Adachi; Takashi Taga; Daisuke Tomizawa; Motomi Osato; Tomoyoshi Soga; Kazuhiro Morishita; Hiroshi Moritake
Haematologica, 2019年10月, 査読あり, 招待無し

PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia-initiating cells.
Tianyuan Hu; Kiyomi Morita; Matthew C Hill; Yajian Jiang; Ayumi Kitano; Yusuke Saito; Feng Wang; Xizeng Mao; Kevin A Hoegenauer; Kazuhiro Morishita; James F Martin; P Andrew Futreal; Koichi Takahashi; Daisuke Nakada
Blood, 2019年08月, 査読あり, 招待無し

Long-term Remission of Acute Myeloid Leukemia Developed From Systemic Mastocytosis by Conventional Chemotherapy.
Ai Yamada; Mariko Kinoshita; Daisuke Sawa; Yusuke Saito; Sachiyo Kamimura; Hayato Miyachi; Hiroshi Moritake
Journal of pediatric hematology/oncology, 2019年08月, 査読あり, 招待無し

CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis.
Akira Suekane; Yusuke Saito; Shingo Nakahata; Tomonaga Ichikawa; Honami Ogoh; Kazutake Tsujikawa; Kazuhiro Morishita
Scientific reports, 2019年01月, 査読あり, 招待無し

[Acute myeloid leukemia evolving from KIT D816-mutated systemic mastocytosis relapsing two months after completion of chemotherapy].
Takuro Harao; Ai Yamada; Mariko Kinoshita; Daisuke Sawa; Yusuke Saito; Sachiyo Kamimura; Hayato Miyachi; Takashi Ogino; Yuichi Kodama; Yasuhiro Okamoto; Yoshifumi Kawano; Hiroshi Moritake
[Rinsho ketsueki] The Japanese journal of clinical hematology, 2019年, 査読あり, 招待無し

Haploinsufficiency of SNX13 contributes to leukemogenesis as a responsive gene for monosomy 7 in EVI1 high AML
Ogoh Honami; Suekane Akira; Saito Yusuke; Kaneda Kazuko; Nawin Manachai; Morishita Kazuhiro
CANCER SCIENCE, 2018年12月, 査読あり, 招待無し

CGRP-CRLR/RAMP1 signal regulated by EVI1 promotes leukemogenesis
Suekane Akira; Saito Yusuke; Nakahata Shingo; Ogoh Honami; Ichikawa Tomonaga; Nawin Manachai; Matin Juliana Farha; Kaneda Kazuko; Osato Motomi; Morishita Kazuhiro
CANCER SCIENCE, 2018年12月, 査読あり, 招待無し

EVI1 in Acute Myeloid Leukemia Triggers Metabolic Reprograming Associated with Leukemogenesis and Increases Sensitivity to L-Aspalaginase
Saito Yusuke; Sawa Daisuke; Kinoshita Mariko; Yamada Ai; Kamimura Sachiyo; Morishita Kazuhiro; Soga Tomoyoshi; Moritake Hiroshi
BLOOD, 2018年11月, 査読あり, 招待無し

Suppression of GPR56 expression by pyrrole-imidazole polyamide represents a novel therapeutic drug for AML with high EVI1 expression.
Hasi Rani Saha; Kazuko Kaneda-Nakashima; Shunsuke Shimosaki; Akira Suekane; Bidhan Sarkar; Yusuke Saito; Honami Ogoh; Shingo Nakahata; Kentaro Inoue; Takayoshi Watanabe; Hiroki Nagase; Kazuhiro Morishita
Scientific reports, 2018年09月, 査読あり, 招待無し

CGRP-CRLR/RAMP1シグナルはストレス造血において重要である(CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis)
末金 彰; 齋藤 祐介; 中畑 新吾; 市川 朝永; 小河 穂波; 辻川 和丈; 森下 和広
臨床血液, 2018年09月

SNX13のハプロ不全はEVI1高発現AMLのmonosomy 7における原因遺伝子として白血病化に寄与している(Haploinsufficiency of SNX13 contributes to leukemogenesis as a responsive gene for monosomy 7 in EVI1 high AML)
小河 穂波; 末金 彰; 齋藤 祐介; 兼田 加珠子; ナーウィン・マナチャイ; 森下 和広
日本癌学会総会記事, 2018年09月

Short-form of BCL11B contributes to tumorigenesis of adult T-cell leukemia/lymphoma
Permatasari Happy; Nakahata Shingo; Ichikawa Tomonaga; Saito Yusuke; Taki Tomohiko; Taniwaki Masafumi; Morishita Kazuhiro
CANCER SCIENCE, 2018年01月, 査読あり, 招待無し

Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages
Y. Komohara; C. Ma; H. Yano; C. Pan; H. Horlad; Y. Saito; K. Ohnishi; Y. Fujiwara; Y. Okuno; K. Nosaka; S. Shimosaki; K. Morishita; M. Matsuoka; T. Wakayama; M. Takeya
J Clin Exp Hematop., 2017年07月, 査読あり, 招待無し

A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin.
Hiroshi Moritake; Megumi Obara; Yusuke Saito; Ayako Kashimada; Masatoshi Takagi; Megumi Funakoshi-Tago; Tomofusa Fukuyama; Mikio Yoshioka; Akira Inoue; Hiroyuki Komatsu; Hideki Nishitoh; Hiroaki Kataoka; Hiroyuki Nunoi
Human cell, 2017年04月, 査読あり, 招待無し

Activation of EVI1 transcription by the LEF1/β-catenin complex with p53-alteration in myeloid blast crisis of chronic myeloid leukemia.
Nawin Manachai; Yusuke Saito; Shingo Nakahata; Avinash Govind Bahirvani; Motomi Osato; Kazuhiro Morishita
Biochemical and biophysical research communications, 2017年01月, 査読あり, 招待無し

Ghrelin does not influence cancer progression in a lung adenocarcinoma cell line.
Hironobu Tsubouchi; Hitomi Onomura; Yusuke Saito; Shigehisa Yanagi; Ayako Miura; Ayako Matsuo; Nobuhiro Matsumoto; Masamitsu Nakazato
Endocrine journal, 2017年, 査読あり, 招待無し

EVI1高発現急性骨髄性白血病における神経因性ペプチドシグナル
末金 彰; 齋藤 祐介; 森下 和広
日本癌学会総会記事, 2016年10月

AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow.
Yusuke Saito; Richard H Chapple; Angelique Lin; Ayumi Kitano; Daisuke Nakada
Cell stem cell, 2015年11月, 査読あり, 招待無し

GPR56とCD52はEVI1高発現白血病の新たな治療標的分子である(GPR56 and CD52 as a new molecular target of acute myeloid leukemia with high EVI1 expression)
齋藤 祐介; 兼田 加珠子; 下崎 俊介; 末金 彰; 森下 和広
日本小児血液・がん学会雑誌, 2015年10月

INHIBITION OF GPR56 BY PI-POLYAMIDE TARGETING THE EVI1-BINDING SITE WITH SUPPRESSION OF LEUKEMIA
Kaneda Kazuko N; Saito Yusuke; Suekane Akira; Shimosaki Shunsuke; Morishita Kazuhiro
EXPERIMENTAL HEMATOLOGY, 2015年09月, 査読あり, 招待無し

DOWN-REGULATION OF NDRG2 PLAYS AN IMPORTANT ROLE IN ATLL LEUKEMOGENESIS VIA THE PTEN-MEDIATED PI3K/AKT SIGNALING PATHWAY
Nakahata Shingo; Ichikawa Tomonaga; Yusuke Saito; Arai Yasuhito; Taki Tomohiko; Taniwaki Masafumi; Morishita Kazuhiro
EXPERIMENTAL HEMATOLOGY, 2015年09月, 査読あり, 招待無し

[Maintenance of leukemic and normal hematopoietic stem cells in bone marrow niches by EVI1-regulated GPR56].
Yusuke Saito; Kazuhiro Morishita
[Rinsho ketsueki] The Japanese journal of clinical hematology, 2015年04月, 査読あり, 招待無し

Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.
Shingo Nakahata; Tomonaga Ichikawa; Phudit Maneesaay; Yusuke Saito; Kentaro Nagai; Tomohiro Tamura; Nawin Manachai; Norio Yamakawa; Makoto Hamasaki; Issay Kitabayashi; Yasuhito Arai; Yae Kanai; Tomohiko Taki; Takaya Abe; Hiroshi Kiyonari; Kazuya Shimoda; Koichi Ohshima; Akira Horii; Hiroshi Shima; Masafumi Taniwaki; Ryoji Yamaguchi; Kazuhiro Morishita
Nature communications, 2014年02月, 査読あり, 招待無し

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.
Daisuke Nakada; Hideyuki Oguro; Boaz P Levi; Nicole Ryan; Ayumi Kitano; Yusuke Saitoh; Makiko Takeichi; George R Wendt; Sean J Morrison
Nature, 2014年01月, 査読あり, 招待無し

The role of the Lkb1/AMPK pathway in hematopoietic stem cells and Leukemia.
Yusuke Saito; Daisuke Nakada
Critical reviews in oncogenesis, 2014年, 査読あり, 招待無し

AMLに対するインテグリン中和抗体の治療効果に関する検討(Investigation of therapeutic efficacy of neutralizing antibody of integrin for AML)
兼田 加珠子[中島]; 末金 彰; 斎藤 祐介; 山川 哲生; 黒澤 仁; 森下 和広
日本癌学会総会記事, 2013年10月

Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56.
Y Saito; K Kaneda; A Suekane; E Ichihara; S Nakahata; N Yamakawa; K Nagai; N Mizuno; K Kogawa; I Miura; H Itoh; K Morishita
Leukemia, 2013年08月, 査読あり, 招待無し

Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma.
S Nakahata; Y Saito; K Marutsuka; T Hidaka; K Maeda; K Hatakeyama; T Shiraga; A Goto; N Takamatsu; Y Asada; A Utsunomiya; A Okayama; Y Kubuki; K Shimoda; Y Ukai; G Kurosawa; K Morishita
Leukemia, 2012年06月, 査読あり, 招待無し

Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation.
Yuudai Kondo; Kentaro Nagai; Shingo Nakahata; Yusuke Saito; Tomonaga Ichikawa; Akira Suekane; Tomohiko Taki; Reika Iwakawa; Masato Enari; Masafumi Taniwaki; Jun Yokota; Sumio Sakoda; Kazuhiro Morishita
Cancer science, 2012年04月, 査読あり, 招待無し

The increased expression of integrin α6 (ITGA6) enhances drug resistance in EVI1(high) leukemia.
Norio Yamakawa; Kazuko Kaneda; Yusuke Saito; Emi Ichihara; Kazuhiro Morishita
PloS one, 2012年, 査読あり, 招待無し

Angiopoietin1 contributes to the maintenance of cell quiescence in EVI1(high) leukemia cells.
Emi Ichihara; Kazuko Kaneda; Yusuke Saito; Norio Yamakawa; Kazuhiro Morishita
Biochemical and biophysical research communications, 2011年12月, 査読あり, 招待無し

Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation
I. Nishikata; S. Nakahata; Y. Saito; K. Kaneda; E. Ichihara; N. Yamakawa; K. Morishita
ONCOGENE, 2011年10月, 査読あり, 招待無し

CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression.
Y Saito; S Nakahata; N Yamakawa; K Kaneda; E Ichihara; A Suekane; K Morishita
Leukemia, 2011年06月, 査読あり, 招待無し

成人T細胞白血病細胞におけるCDKN1A遺伝子の転写はプロモーターのメチル化とZEB1発現低下により抑制される
中畑 新吾; 渡邊 正明; 浜崎 誠; 斎藤 祐介; 河野 洋平; 森下 和広
臨床血液, 2010年09月

Downregulation of CDKN1A in adult T-cell leukemia/lymphoma despite overexpression of CDKN1A in human T-lymphotropic virus 1-infected cell lines.
Masaaki Watanabe; Shingo Nakahata; Makoto Hamasaki; Yusuke Saito; Yohei Kawano; Tomonori Hidaka; Kiyoshi Yamashita; Kazumi Umeki; Tomohiko Taki; Masafumi Taniwaki; Akihiko Okayama; Kazuhiro Morishita
Journal of virology, 2010年07月, 査読あり, 招待無し

Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma.
Shingo Nakahata; Yusuke Saito; Makoto Hamasaki; Tomonori Hidaka; Yasuhito Arai; Tomohiko Taki; Masafumi Taniwaki; Kazuhiro Morishita
Genes, chromosomes & cancer, 2009年09月, 査読あり, 招待無し

NDRG2は成人T細胞白血病のがん抑制遺伝子候補である(NDRG2 is a candidate tumor suppressor gene in adult-T cell leukemia/lymphoma)
濱崎 誠; 中畑 信吾; 斎藤 祐介; 河野 洋平; 新井 康仁; 滝 智彦; 谷脇 雅史; 森下 和広
日本癌学会総会記事, 2009年08月

Long-term survival after autologous peripheral blood stem cell transplantation in two patients with malignant rhabdoid tumor of the kidney.
Yuhki Koga; Akinobu Matsuzaki; Aiko Suminoe; Miho Hatano; Yusuke Saito; Yoshiaki Kinoshita; Tatsuro Tajiri; Tomoaki Taguchi; Kenichi Kohashi; Yoshinao Oda; Masazumi Tsuneyoshi; Toshiro Hara
Pediatric blood & cancer, 2009年07月, 査読あり, 招待無し

Congenital Ewing sarcoma in retroperitoneum with multiple metastases.
Yusuke Saito; Akinobu Matsuzaki; Aiko Suminoe; Yuhki Koga; Hiroaki Kurata; Yoshinao Oda; Masazumi Tsuneyoshi; Toshiro Hara
Pediatric blood & cancer, 2008年11月, 査読あり, 招待無し

[Alveolar rhabdomyosarcoma of unknown origin mimicking acute leukemia at the initial presentation].
Kan Yamaguchi; Yuhki Koga; Aiko Suminoe; Yusuke Saito; Akinobu Matsuzaki; Shunsuke Kanno; Tomohito Takimoto; Masahiro Suda; Yoshinao Oda; Toshitaka Muto; Hiroshi Takatsuki; Toshiro Hara
[Rinsho ketsueki] The Japanese journal of clinical hematology, 2007年04月

Bone marrow transplantation in children with severe aplastic anemia using a conditioning regimen containing 3 Gy of total body irradiation, cyclophosphamide with or without antithymocyte globulin.
Jiro Inagaki; Yoshihisa Nagatoshi; Yoshifumi Kawano; Yusuke Saito; Daijiro Takahashi; Jun Nagayama; Yuichi Shinkoda; Hideki Hirata; Jun Okamura
Pediatric transplantation, 2007年03月

Successful umbilical cord blood transplantation for severe chronic active Epstein-Barr virus infection after the double failure of hematopoietic stem cell transplantation.
Masataka Ishimura; Shouichi Ohga; Akihiko Nomura; Taikai Toubo; Eiji Morihana; Yusuke Saito; Hisanori Nishio; Makoto Ide; Hidetoshi Takada; Toshiro Hara
American journal of hematology, 2005年11月, 査読あり, 招待無し

Bronchiolitis obliterans organizing pneumonia as an initial manifestation in systemic lupus erythematosus.
Hidetoshi Takada; Yusuke Saito; Akihiko Nomura; Shouichi Ohga; Kazuyoshi Kuwano; Nobutaka Nakashima; Shinichi Aishima; Noboru Tsuru; Toshiro Hara
Pediatric pulmonology, 2005年09月, 査読あり, 招待無し