SAMD4 represses VGLL4 mRNA to activate TEAD and promote cancer progression.
Junji Otani; Miki Nishio; Riko Tokita; Hiroki Hikasa; Makoto Nishimori; Shingo Dan; Isao Naguro; Hidenori Ichijo; Masanori Miyanishi; Takehiko Sasaki; Hiroshi Nishina; Tak Wah Mak; Tomohiko Maehama; Akira Suzuki
Oncogene, Apr. 2026

MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes
Miki Nishio; Keiko Yamaguchi; Junji Otani; Katsuya Yuguchi; Daisuke Kohno; Tsutomu Sasaki; Tadahiro Kitamura; Masakazu Shinohara; Tomoyoshi Soga; Koichi Kawamura; Atsuo T. Sasaki; Masashi Oshima; Hiroki Hikasa; Minna Woo; Takehiko Sasaki; Hiroshi Nishina; Kazuwa Nakao; Tomohiko Maehama; Akira Suzuki
Proceedings of the National Academy of Sciences, Apr. 2025, Reviewed

A highly sensitive reporter system to monitor endogenous YAP1/TAZ activity and its application in various human cells.
Hiroki Hikasa; Kohichi Kawahara; Masako Inui; Yukichika Yasuki; Keita Yamashita; Kohei Otsubo; Shojiro Kitajima; Miki Nishio; Kazunari Arima; Motoyoshi Endo; Masanori Taira; Akira Suzuki
Cancer science, Oct. 2024

N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ.
Yusuke Shiraishi; Tomohiko Maehama; Miki Nishio; Junji Otani; Hiroki Hikasa; Tak Wah Mak; Takehiko Sasaki; Teruki Honma; Yasumitsu Kondoh; Hiroyuki Osada; Minoru Yoshida; Masato Fujisawa; Akira Suzuki
Genes to cells : devoted to molecular & cellular mechanisms, Oct. 2022

Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation.
Keisuke Nakatani; Tomohiko Maehama; Miki Nishio; Junji Otani; Keiko Yamaguchi; Miki Fukumoto; Hiroki Hikasa; Shinji Hagiwara; Hiroshi Nishina; Tak Wah Mak; Teruki Honma; Yasumitsu Kondoh; Hiroyuki Osada; Minoru Yoshida; Akira Suzuki
Cancer science, Oct. 2021

Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.
Miki Nishio; Yoko To; Tomohiko Maehama; Yukari Aono; Junji Otani; Hiroki Hikasa; Akihiro Kitagawa; Koshi Mimori; Takehiko Sasaki; Hiroshi Nishina; Shinya Toyokuni; John P Lydon; Kazuwa Nakao; Tak Wah Mak; Tohru Kiyono; Hidetaka Katabuchi; Hironori Tashiro; Akira Suzuki
Cancer science, Oct. 2020

YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.
Hirofumi Omori; Miki Nishio; Muneyuki Masuda; Yosuke Miyachi; Fumihito Ueda; Takafumi Nakano; Kuniaki Sato; Koshi Mimori; Kenichi Taguchi; Hiroki Hikasa; Hiroshi Nishina; Hironori Tashiro; Tohru Kiyono; Tak Wah Mak; Kazuwa Nakao; Takashi Nakagawa; Tomohiko Maehama; Akira Suzuki
Science advances, Mar. 2020

Hypoxia-inducible factor-1α promotes cell survival during ammonia stress response in ovarian cancer stem-like cells.
Shojiro Kitajima; Kian Leong Lee; Hiroki Hikasa; Wendi Sun; Ruby Yun-Ju Huang; Henry Yang; Shinji Matsunaga; Takehiro Yamaguchi; Marito Araki; Hiroyuki Kato; Lorenz Poellinger
Oncotarget, Dec. 2017

Merlin/NF2-Lin28B-let-7 Is a Tumor-Suppressive Pathway that Is Cell-Density Dependent and Hippo Independent.
Hiroki Hikasa; Yoshitaka Sekido; Akira Suzuki
Cell reports, Mar. 2016

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.
Miki Nishio; Keishi Sugimachi; Hiroki Goto; Jia Wang; Takumi Morikawa; Yosuke Miyachi; Yusuke Takano; Hiroki Hikasa; Tohru Itoh; Satoshi O Suzuki; Hiroki Kurihara; Shinichi Aishima; Andrew Leask; Takehiko Sasaki; Toru Nakano; Hiroshi Nishina; Yuji Nishikawa; Yoshitaka Sekido; Kazuwa Nakao; Kazuo Shin-Ya; Koshi Mimori; Akira Suzuki
Proceedings of the National Academy of Sciences of the United States of America, Jan. 2016

Wnt signaling in vertebrate axis specification.
Hiroki Hikasa; Sergei Y Sokol
Cold Spring Harbor perspectives in biology, Jan. 2013

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.
Miki Nishio; Koichi Hamada; Kohichi Kawahara; Masato Sasaki; Fumihito Noguchi; Shuhei Chiba; Kensaku Mizuno; Satoshi O Suzuki; Youyi Dong; Masaaki Tokuda; Takumi Morikawa; Hiroki Hikasa; Jonathan Eggenschwiler; Norikazu Yabuta; Hiroshi Nojima; Kentaro Nakagawa; Yutaka Hata; Hiroshi Nishina; Koshi Mimori; Masaki Mori; Takehiko Sasaki; Tak W Mak; Toru Nakano; Satoshi Itami; Akira Suzuki
The Journal of clinical investigation, Dec. 2012

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.
Masato Sasaki; Kohichi Kawahara; Miki Nishio; Koshi Mimori; Ryunosuke Kogo; Koichi Hamada; Bunsho Itoh; Jia Wang; Yukako Komatsu; Yong Ryoul Yang; Hiroki Hikasa; Yasuo Horie; Takayuki Yamashita; Takehiko Kamijo; Yanping Zhang; Yan Zhu; Carol Prives; Toru Nakano; Tak Wah Mak; Takehiko Sasaki; Tomohiko Maehama; Masaki Mori; Akira Suzuki
Nature medicine, Jul. 2011

Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.
Hiroki Hikasa; Sergei Y Sokol
The Journal of biological chemistry, Apr. 2011

Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification.
Hiroki Hikasa; Jerome Ezan; Keiji Itoh; Xiaotong Li; Michael W Klymkowsky; Sergei Y Sokol
Developmental cell, Oct. 2010

Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals.
Jae-il Park; Hong Ji; Sohee Jun; Dongmin Gu; Hiroki Hikasa; Lei Li; Sergei Y Sokol; Pierre D McCrea
Developmental cell, Nov. 2006

Xenopus ADAMTS1 negatively modulates FGF signaling independent of its metalloprotease activity.
Akiko Suga; Hiroki Hikasa; Masanori Taira
Developmental biology, Jul. 2006

Vertebrate homologues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements.
Nina L Hunter; Hiroki Hikasa; Susan M Dymecki; Sergei Y Sokol
Developmental dynamics : an official publication of the American Association of Anatomists, Jan. 2006

Role of crescent in convergent extension movements by modulating Wnt signaling in early Xenopus embryogenesis.
Mikihito Shibata; Mari Itoh; Hiroki Hikasa; Sumiko Taira; Masanori Taira
Mechanisms of development, Dec. 2005

Reorganization of actin cytoskeleton by FRIED, a Frizzled-8 associated protein tyrosine phosphatase.
Keiji Itoh; Mikhail Lisovsky; Hiroki Hikasa; Sergei Y Sokol
Developmental dynamics : an official publication of the American Association of Anatomists, Sep. 2005

The involvement of Frodo in TCF-dependent signaling and neural tissue development.
Hiroki Hikasa; Sergei Y Sokol
Development (Cambridge, England), Oct. 2004

TLR/IL-1R経路構成因子ヒトIRAK1のマウス肺特異的過剰発現の解析
三村 恭弘, 大坪 孝平, 平良 眞規, 日笠 弘基
日本生化学会大会プログラム・講演要旨集, Oct. 2023, Not reviewed, No invitation
Last

TLR/IL-1R経路構成因子ヒトIRAK1マウスの肺特異的過剰発現の解析
三村 恭弘, 宮田 博規, 遠藤 元誉, 早川 佳香, 山本 知世, 坂井 公紀, 日笠 弘基
産業医科大学雑誌, Mar. 2024, Null, Null

TLR/IL-1R経路構成因子ヒトIRAK1マウスの肺特異的過剰発現の解析
三村 恭弘, 宮田 博規, 遠藤 元誉, 早川 佳香, 山本 知世, 坂井 公紀, 日笠 弘基
産業医科大学雑誌, Mar. 2024, Null, Null

ゲノム編集によるヒト化Irak1マウスおよび組織特異的ヒトIRAK1発現マウスの樹立と病態解析
三村 恭弘, 日笠 弘基
産業医科大学雑誌, Mar. 2023, Null, Null

ヒトIRAK1はToll様受容体/IL-1受容体経路とWnt/β-カテニン経路を同時に活性化する
三村 恭弘, 日笠 弘基
産業医科大学雑誌, Mar. 2022, Null, Null

A highly sensitive reporter system to monitor endogenous YAP1/TAZ activity and its application in various human cells.
Hikasa Hiroki, Kawahara Kohichi, Inui Masako, Yasuki Yukichika, Yamashita Keita, Otsubo Kohei, Kitajima Shojiro, Nishio Miki, Arima Kazunari, Endo Motoyoshi, Taira Masanori, Suzuki Akira
Cancer science, Oct. 2024, Reviewed, Null
Lead

Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation.
Nakatani Keisuke, Maehama Tomohiko, Nishio Miki, Otani Junji, Yamaguchi Keiko, Fukumoto Miki, Hikasa Hiroki, Hagiwara Shinji, Nishina Hiroshi, Mak Tak Wah, Honma Teruki, Kondoh Yasumitsu, Osada Hiroyuki, Yoshida Minoru, Suzuki Akira
Cancer science, Oct. 2021, Null, Null

N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ.
Shiraishi Yusuke, Maehama Tomohiko, Nishio Miki, Otani Junji, Hikasa Hiroki, Mak Tak Wah, Sasaki Takehiko, Honma Teruki, Kondoh Yasumitsu, Osada Hiroyuki, Yoshida Minoru, Fujisawa Masato, Suzuki Akira
Genes to cells : devoted to molecular & cellular mechanisms, Oct. 2022, Null, Null

Hypoxia-inducible factor-1α promotes cell survival during ammonia stress response in ovarian cancer stem-like cells
Hiroki Hikasa
Oncotarget, Dec. 2017, Null, Null

マウス成熟脂肪細胞におけるMOB1欠損は肥満や糖尿病を改善する
Nishio Miki, Yamaguchi Keiko, Otani Junji, Yuguchi Katsuya, Kohno Daisuke, Sasaki Tsutomu, Kitamura Tadahiro, Shinohara Masakazu, Soga Tomoyoshi, Kawamura Koichi, Sasaki Atsuo T, Oshima Masashi, Hikasa Hiroki, Woo Minna, Sasaki Takehiko, Nishina Hiroshi, Nakao Kazuwa, Maehama Tomohiko, Suzuki Akira
Proceedings of the National Academy of Sciences of the United States of America, Apr. 2025, Reviewed, Null

Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.
Nishio Miki, To Yoko, Maehama Tomohiko, Aono Yukari, Otani Junji, Hikasa Hiroki, Kitagawa Akihiro, Mimori Koshi, Sasaki Takehiko, Nishina Hiroshi, Toyokuni Shinya, Lydon John P, Nakao Kazuwa, Wah Mak Tak, Kiyono Tohru, Katabuchi Hidetaka, Tashiro Hironori, Suzuki Akira
Cancer science, Oct. 2020, Null, Null

YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.
Omori Hirofumi, Nishio Miki, Masuda Muneyuki, Miyachi Yosuke, Ueda Fumihito, Nakano Takafumi, Sato Kuniaki, Mimori Koshi, Taguchi Kenichi, Hikasa Hiroki, Nishina Hiroshi, Tashiro Hironori, Kiyono Tohru, Mak Tak Wah, Nakao Kazuwa, Nakagawa Takashi, Maehama Tomohiko, Suzuki Akira
Science advances, Mar. 2020, Null, Null