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Last Updated :2026/06/12
Internal Medicine 3
In-house Lecturer
Research activity information
■ Paper
- 治るがん、治らないがん
大江 晋司
毎日新聞, Nov. 2025 - 治るがん、治らないがん
大江 晋司
毎日新聞, Oct. 2025 - 治るがん、治らないがん
大江 晋司
毎日新聞, Sep. 2025 - Multimodal Treatment Approach for Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms of the Gallbladder: A Patient with a Favorable Survival Outcome
Shinji Oe; Koichi Nakamura; Nobuhiko Shinohara; Daiki Uchihara; Koichiro Miyagawa; Teppei Tsukamoto; Yasuhisa Mori; Masaru Harada
Internal Medicine, Aug. 2025, Reviewed
Lead, Corresponding - 【内科医が見逃してはいけない治療可能な代謝性神経疾患】ウイルソン病
原田 大; 大江 晋司; 本間 雄一
日本内科学会雑誌, Aug. 2025 - Long-chain fatty acyl CoA synthetase 4 expression in pancreatic cancer: a marker for malignant lesions and prognostic indicator for recurrence
Daiki Uchihara; Shohei Shimajiri; Yoshikazu Harada; Keiichiro Kumamoto; Shinji Oe; Koichiro Miyagawa; Koichi Nakamura; Eisuke Katafuchi; Fariza Nuratdinova; Yuichi Honma; Michihiko Shibata; Masaru Harada; Toshiyuki Nakayama
Diagnostic Pathology, May 2025, Reviewed - Rectal metastasis from lung cancer diagnosed by endoscopic ultrasound‐guided fine needle biopsy: A case report
Shinji Mukawa; Yudai Koya; Tomoyuki Murakami; Koichiro Miyagawa; Yuki Maruno; Koki Yamaguchi; Shun Hanada; Shinji Oe; Masaru Harada
DEN Open, Apr. 2025, Reviewed - Usefulness of the Early Increase of Peripheral Blood Lymphocyte Count in Predicting Clinical Outcomes for Patients with Advanced Hepatocellular Carcinoma Treated with Durvalumab Plus Tremelimumab
Yuichi Honma; Michihiko Shibata; Masatoshi Ikemi; Kengo Yoshitomi; Nobuhiko Shinohara; Noriyoshi Ogino; Shinji Oe; Koichiro Miyagawa; Shintaro Abe; Masaru Harada
Cancers, Apr. 2025, Reviewed - Post-EUS-FNB Mediastinal Abscess in a Lung Cancer Patient With Mediastinal Lymph Node Metastasis: A Case Report and Literature Review
Koichiro MIYAGAWA; Daiki UCHIHARA; Tsuyoshi UEDA; Kosuke HIDESHIMA; Nobuhiko SHINOHARA; Shinji OE; Yuichi HONMA; Masaru HARADA
Journal of UOEH, Apr. 2025, Reviewed - Feasibility and safety of EUS-guided biliary drainage in inexperienced centers: a multicenter study in southwest Japan.
Takehiko Koga; Yusuke Ishida; Shunpei Hashigo; Yuzo Shimokawa; Hirofumi Harima; Kazuhisa Okamoto; Akihisa Ohno; Tsukasa Miyagahara; Toshihiro Fujita; Satoshi Fukuchi; Kosuke Takahashi; Hiroki Taguchi; Norimasa Araki; Yuichiro Ohtsuka; Toshiyuki Uekitani; Kengo Tsuneyoshi; Takumi Akiyama; Noriko Ishigaki; Toru Maruo; Hirokazu Saito; Ryo Ihara; Akihiro Yamasuji; Shinji Oe; Motohiro Yoshinari; Ryota Sagami; Nao Fujimori; Yoshio Fukuda; Eisuke Ozawa; Kenichi Jikuya; Hiroki Shinohara; Manabu Sen-Yo; Toshiharu Ueki; Naoaki Tsuchiya; Takanori Kitaguchi; Keisuke Matsumoto; Makoto Fukuyama; Fumihito Hirai
Gastrointestinal endoscopy, Apr. 2025 - Authors response: "An Unusual Abscess Associated with Gallbladder Perforation Successfully Treated with Percutaneous Transhepatic Gallbladder Drainage and Endoscopic Ultrasound-guided Abscess Drainage"
Koichiro Miyagawa; Nobuhiko Shinohara; Shinji Oe; Masaru Harada
Internal Medicine, Jan. 2025, Reviewed - ウイルソン病
原田 大、大江 晋司
ディサースリア臨床研究, Dec. 2019, Reviewed, Null - 急性膵炎発症1年後に広範な主膵管内進展を伴う膵腺房細胞癌が出現し膵全摘術を施行した1例
金野 剛, 森 泰寿, 厚井 志郎, 田村 利尚, 佐藤 典宏, 永田 淳, 大江 晋司, 小松 和貴, 久岡 正典, 柴尾 和徳, 平田 敬治
日本消化器外科学会雑誌, Oct. 2024, Reviewed, No invitation - ウイルス性肝炎関連肝癌症例の通院状況に関する検討
柴田 道彦, 南 創太, 大江 晋司, 宮川 恒一郎, 本間 雄一, 鬼塚 良, 千手 倫夫, 日浦 政明, 原田 理子, 阿部 慎太郎, 田原 章成, 原田 大
日本消化器病学会雑誌, Oct. 2016, Reviewed, Null - ウイルソン病
原田 大, 草永 真志, 大江 晋司, 本間 雄一
消化器・肝臓内科, May 2021, Reviewed, Null - 【肝硬変の治療薬-どのように使いこなすか?】 酢酸亜鉛水和物製剤
原田 大, 大江 晋司, 草永 真志, 本間 雄一
消化器・肝臓内科, Sep. 2018, Reviewed, Null - 【消化器内科医が知っておくべき小児疾患と移行期医療】 ウイルソン病(Wilson病)
原田 大, 大江 晋司, 草永 真志, 本間 雄一
消化器・肝臓内科, Dec. 2017, Reviewed, Null - 【NASH/NAFLDの新知見】 NASH/NAFLDの病理 Mallory-Denk体と細胞ストレス
原田 大, 本間 雄一, 大江 晋司, 南 創太, 草永 真志
肝・胆・膵, Apr. 2018, Reviewed, Null - 【肝硬変を理解する-分子機構から実臨床に至るまで-】 原因別にみた病態と進展の特徴 ウイルソン病(Wilson病)
原田 大, 大江 晋司
肝・胆・膵, Dec. 2016, Reviewed, Null - 知っておきたい稀な肝胆膵疾患 ウイルソン病
原田 大, 大江 晋司, 本間 雄一
肝・胆・膵, Jan. 2016, Reviewed, Null - 【診療ガイドライン改訂後の膵炎診療】感染性膵壊死に対するステップアップ・アプローチ 内視鏡的と外科的どちらが有用か
森 泰寿, 大江 晋司, 田村 利尚, 大場 拓哉, 厚井 志郎, 佐藤 典宏, 柴尾 和徳, 平田 敬治
肝胆膵, Mar. 2022, Reviewed, No invitation - 【小児期発症慢性肝疾患における移行期医療の現状と課題-小児と成人のダイアログ-】ウィルソン病 小児期からの発症病態と長期的肝胆道合併症
原田 大, 大江 晋司, 草永 真志, 本間 雄一
肝胆膵, Mar. 2021, Reviewed, Null - TfR2ヘテロ接合型変異で発症したヘモクロマトーシスの1例
西尾 仁, 本間 雄一, 熊元 啓一郎, 土岐 康通, 森野 加帆里, 大江 晋司, 宮川 恒一郎, 柴田 道彦, 阿部 慎太郎, 巽 康彰, 生田 克哉, 林 久男, 原田 大
肝臓, Mar. 2022, Reviewed, Null - アルコールによる肝細胞障害－分子病理的解析-
原田 大, 大江 晋司, 宮川 恒一郎, 草永 真志, 本間 雄一, 吉富 健悟
肝･胆･膵, Apr. 2023, Reviewed, Null - Lipid-Induced Endoplasmic Reticulum Stress Impairs Selective Autophagy at the Step of Autophagosome-Lysosome Fusion in Hepatocytes.
Miyagawa Koichiro, Oe Shinji, Honma Yuichi, Izumi Hiroto, Baba Ryoko, Harada Masaru
The American journal of pathology, Jul. 2016, Reviewed, No invitation - Antiplatelet therapy improves the prognosis of patients with hepatocellular carcinoma.
Hayashi T, Shibata M, Oe S, Miyagawa K, Honma Y, Harada M.
Cancers, Oct. 2020, Reviewed, Null - Symptomatic liver cyst successfully treated with transgastric drainage and sclerotherapy using minocycline hydrochloride.
Yoshitomi K, Koya Y, Miyagawa K, Maruno Y, Yamaguchi K, Taniguchi R, Onitsuka K, Sakamoto Y, Oe S, Harada M
Case Reports in Gastrointestinal Medicine, Jan. 2024, Reviewed, Null - IgG4-related hepatic inflammatory pseudotumor in a patient with serum IgG4-negative type 1 autoimmune pancreatitis.
Hideshima K, Suzuki T, Oe S, Shinohara N, Matuhashi N, Ichii O, Tai M, Ejiri Y, Miyagawa K, Harada M
Clinical Journal of Gastroenterology, Dec. 2023, Reviewed, Null - A case of adrenal metastasis of hepatocellular carcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration.
Ueda T, Oe S, Yoneda A, Koya Y, Nebuya S, Miyagawa K, Honma Y, Shibata M, Shimajiri S, Harada M
DEN Open, Apr. 2024, Reviewed, Null - Rectal metastasis from lung cancer diagnosed by endoscopic ultrasound-guided fine needle biopsy: A case report.
Mukawa S, Koya Y, Murakami T, Miyagawa K, Maruno Y, Yamaguchi K, Hanada S, Oe S, Harada M
DEN open, Apr. 2026, Reviewed, Null - Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort.
Naitoh I, Kamisawa T, Tanaka A, Nakazawa T, Kubota K, Takikawa H, Unno M, Masamune A, Kawa S, Nakamura S, Okazaki K,…Oe S, Harada M, Kurata M, Fukasawa M, Enomoto N, Kawaji Y, Kitano M, Nishise Y, Hirakawa H, Ishizawa T, Ueno Y, Kaino M, Fujimoto Y, Sakaida I, Kubota K.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, Oct. 2021, Reviewed, Null - Impact of Interferon-free direct-acting antivirals on the incidence of extrahepatic malignancies in patients with chronic hepatitis C.
Honma Y, Shibata M, Morino K, Koya Y, Hayashi T, Ogino N, Kusanaga M, Oe S, Miyagawa K, Abe S, Tabaru A, Harada M
Digestive diseases and sciences, Feb. 2023, Reviewed, Null - Influence of gastroesophageal flap valve on esophageal variceal bleeding in patients with liver cirrhosis.
Koya Y, Shibata M, Watanabe T, Kumei S, Miyagawa K, Oe S, Honma Y, Kume K, Yoshikawa I, Harada M.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, Jan. 2021, Reviewed, Null - Excess glucose alone induces hepatocyte damage due to oxidative stress and endoplasmic reticulum stress.
Hayashi T, Oe S, Miyagawa K, Kusanaga M, Ogino N, Honma Y, Harada M
Experimental Cell Research, Oct. 2024, Reviewed, Null - Involvement of sarco/endoplasmic reticulum calcium ATPase-mediated calcium flux in the protective effect of oleic acid against lipotoxicity in hepatocytes.
Ogino N, Miyagawa K, Kusanaga M, Hayashi T, Minami S, Oe S, Honma Y, Harada M.
Experimental Cell Research, Dec. 2019, Reviewed, Null - Copper induces hepatocyte injury due to the endoplasmic reticulum stress in cultured cells and patients with Wilson disease.
Oe Shinji, Miyagawa Koichiro, Honma Yuichi, Harada Masaru
Experimental cell research, Sep. 2016, Reviewed, Null - Feasibility and safety of EUS-guided biliary drainage in inexperienced centers: a multicenter study in southwest Japan.
Koga T, Ishida Y, Hashigo S, Shimokawa Y, Harima H, Okamoto K, Ohno A, Miyagahara T, Fujita T, Fukuchi S, Takahashi K, Taguchi H, Araki N, Ohtsuka Y, Uekitani T, Tsuneyoshi K, Akiyama T, Ishigaki N, Maruo T, Saito H, Ihara R, Yamasuji A, Oe S, Yoshinari M, Sagami R, Fujimori N, Fukuda Y, Ozawa E, Jikuya K, Shinohara H, Sen-Yo M, Ueki T, Tsuchiya N, Kitaguchi T, Matsumoto K, Fukuyama M, Hirai F
Gastrointestinal Endoscopy, Sep. 2024, Reviewed, Null - Low skeletal muscle mass and high visceral adiposity are associated with recurrence of acute cholecystitis after conservative management: A propensity score-matched cohort study.
Koya Y, Shibata M, Maruno Y, Sakamoto Y, Oe S, Miyagawa K, Honma Y, Harada M
Hepatobiliary & Pancreatic Diseases International : HBPD INT, Feb. 2024, Reviewed, Null - Secondary sclerosing cholangitis with hemobilia induced by pembrolizumab: Case report and review of published work.
Koya Y, Shibata M, Shinohara N, Nebuya S, Oe S, Honma Y, Senju M, Sato N, Harada M
Hepatology Research, Aug. 2019, Reviewed, Null - Alleviation mechanisms against hepatocyte oxidative stress in patients with chronic hepatic disorders.
Hiura Masaaki, Honma Yuichi, Miyagawa Koichiro, Oe Shinji, Shimajiri Shohei, Mihara Hitomi, Oe Masami, Sato-Morita Miyuki, Katsuki Yuka, Harada Masaru
Hepatology research : the official journal of the Japan Society of Hepatology, Nov. 2015, Reviewed, Null - Churg-Strauss syndrome manifesting as cholestasis and diagnosed by liver biopsy.
Harada Masaru, Oe Shinji, Shibata Michihiko, Taguchi Masashi, Matsuhashi Toru, Hiura Masaaki, Abe Shintaro, Harada Riko, Shimajiri Shohei
Hepatology research : the official journal of the Japan Society of Hepatology, Sep. 2012, Reviewed, Null - Multimodal Treatment Approach for Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms of the Gallbladder: A Case Report of a Patient with a Favorable Survival Outcome.
Oe S, Nakamura K, Shinohara N, Uchihara D, Miyagawa K, Tsukamoto T, Mori Y, Harada M.
Internal Medicine (Tokyo, Japan), Aug. 2025, Reviewed, Null
Lead, Corresponding - An unusual abscess associated with gallbladder perforation successfully treated with percutaneous transhepatic gallbladder drainage and endoscopic ultrasound-guided abscess drainage.
Miyagawa K, Kajitani K, Makita T, Hideshima K, Shinohara N, Oe S, Honma Y, Shibata M, Harada M.
Internal Medicine (Tokyo, Japan), Sep. 2024, Reviewed, Null - Autoimmune pancreatitis with gastric cancer: Some IgG4-related diseases may be paraneoplastic syndrome.
Miyagawa K, Kumamoto K, Shinohara N, Watanabe T, Kumei S, Yoneda A, Nebuya S, Koya Y, Oe S, Kume K, Yoshikawa I, Harada M
Internal Medicine (Tokyo, Japan), Jan. 2022, Reviewed, Null - Importance of a liver biopsy in the management of Wilson dsease.
Oe S, Honma Y, Yabuki K, Morino K, Kumamoto K, Hayashi T, Kusanaga M, Ogino N , Minami S, Shibata M, Abe S, Harada M.
Internal Medicine (Tokyo, Japan), Jan. 2020, Reviewed, Invited
Lead, Corresponding - Authors response: "An Unusual Abscess Associated with Gallbladder Perforation Successfully Treated with Percutaneous Transhepatic Gallbladder Drainage and Endoscopic Ultrasound-guided Abscess Drainage".
Miyagawa K, Shinohara N, Oe S, Harada M
Internal medicine (Tokyo, Japan), Jan. 2025, Reviewed, No invitation - Rapidly progressing anaplastic carcinoma of the pancreas with mucoepidermoid carcinoma: An autopsy case report.
Imazu N, Oe S, Tsuda Y, Nebuya S, Koya Y, Miyagawa K, Honma Y, Shibata M, Harada M
Internal medicine (Tokyo, Japan), Jul. 2021, Reviewed, Null - Rapid progression of liver fibrosis induced by acute liver injury due to immune-related adverse events of atezolizumab.
Honma Y, Shibata M, Gohda T, Matsumiya H, Kumamoto K, Miyama A, Morino K, Koya Y, Taira A, Shinohara S, Hayashi T, Kusanaga M, Oe S, Miyagawa K, Abe S, Tanaka F, Harada M.
Internal medicine (Tokyo, Japan), Jan. 2021, Reviewed, Null - Daclatasvir and Asunaprevir Combination Therapy-induced Hepatitis and Cholecystitis with Coagulation Disorder due to Hypersensitivity Reactions.
Miyashima Yuichi, Honma Yuichi, Miyagawa Koichiro, Oe Shinji, Senju Michio, Shibata Michihiko, Hiura Masaaki, Abe Shintaro, Harada Masaru
Internal medicine (Tokyo, Japan), Dec. 2016, Reviewed, Null - Methotrexate-related primary hepatic lymphoma in a patient with rheumatoid arthritis.
Miyagawa Koichiro, Shibata Michihiko, Noguchi Hirotsugu, Hayashi Tsuguru, Oe Shinji, Hiura Masaaki, Abe Shintaro, Harada Masaru
Internal medicine (Tokyo, Japan), Feb. 2015, Reviewed, Null - Refractory primary hepatic actinomycosis with direct infiltration to the diaphragm and thorax: the usefulness of contrast-enhanced ultrasonography.
Oe Shinji, Shibata Michihiko, Hiura Masaaki, Mitsuoka Hiroshi, Matsuhashi Toru, Narita Ryoichi, Abe Shintaro, Tabaru Akinari, Hayashida Kazuhiro, Taniguchi Hatsumi, Harada Masaru
Internal medicine (Tokyo, Japan), Sep. 2014, Reviewed, Null
Lead - Zinc attenuates the cytotoxicity of some stimuli by reducing endoplasmic reticulum stress in hepatocytes.
Kusanaga M, Oe S, Ogino N, Minami S, Miyagawa K, Honma Y, Harada M.
International Journal of Molecular Sciences, May 2019, Reviewed, Null - A Case of successful endoscopic extraction of common bile duct stones after closing a duodenal perforation using over-the-scope clip.
Oe S, Kumei S, Karasuyama T, Shinohara N, Hideshima K, Yoneda A, Miyagawa K, Honma Y, Shibata M, Harada M
Journal of UOEH, Jun. 2023, Null, Null
Lead, Corresponding - Hepatic cyst infection following recurrent biliary obstruction in polycystic liver disease.
Miyagawa K, Nakano Y, Yoneda A, Kusanaga M, Oe S, Honma Y, Shibata M, Harada M
Journal of UOEH, Dec. 2022, Null, Null - A case of pancreatic neuroendocrine tumor G3 which responded remarkably to chemotherapy.
Nebuya S, Oe S, Harada Y, Takeuchi Y, Yoneda A, Koya Y, Miyagawa K, Honma Y, Shibata M, Harada M
Journal of UOEH, Sep. 2022, Reviewed, No invitation - A case of idiopathic gastroesophageal submucosal hematoma and its disappearance observed by endoscopy.
Oe Shinji, Watanabe Tatsuyuki, Kume Keiichiro, Shibata Michihiko, Hiura Masaaki, Yoshikawa Ichiro, Harada Masaru
Journal of UOEH, Jun. 2014, Reviewed, Null
Lead - Reducing relapse through maintenance steroid treatment can decrease the cancer risk in patients with IgG4-sclerosing cholangitis: Based on a Japanese nationwide study
Kensuke Kubota,Terumi Kamisawa, Takahiro Nakazawa, Atsushi Tanaka, Itaru Naitoh,Yusuke Kurita, Hajime Takikawa, Michiaki Unno, Shigeyuki Kawa, Atsushi Masamune, Seiji Nakamura, Kazuichi Okazaki
Journal of gastroenterology and hepatology, Jan. 2023, Reviewed, Null - Impact of sarcopenia on recurrent biliary obstruction after insertion of self-expandable metallic stent in patients with malignant biliary obstruction.
Koya Y, Shibata M, Oe S, Honma Y, Nebuya S, Miyagawa K, Yoshikawa I, Harada M
Journal of hepato-biliary-pancreatic sciences, Jul. 2021, Reviewed, Null - Possible contribution of hepatocyte secretion to the elevation of plasma exosomal arginase-1 in high-fat diet-fed mice.
Ogino N, Takahashi H, Nagaoka K, Harada Y, Kubo M, Miyagawa K, Kusanaga M, Oe S, Honma Y, Harada M, Eitoku M, Suganuma N, Ogino K
Life sciences, May 2021, Reviewed, Null - Effect of direct-acting antivirals on platelet-associated immunoglobulin G and thrombocytopenia in hepatitis C virus-related chronic liver disease.
Honma Y, Shibata M, Hayashi T, Kusanaga M, Ogino N, Minami S, Kumei S, Oe S, Miyagawa K, Senju M, Matsuoka H, Watanabe T, Hiura M, Abe S, Harada M.
Liver International, Sep. 2019, Reviewed, Null - Idiopathic copper toxicosis: is abnormal copper metabolism a primary cause of this disease?
Harada M, Honma Y, Yoshizumi T, Kumamoto K, Oe S, Harada N, Tanimoto A, Yabuki K, Karasuyama T, Yoneda A, Shibata M.
Medical Molecular Morphology, Mar. 2020, Reviewed, Null - Correlation of hepatitis C virus-mediated endoplasmic reticulum stress with autophagic flux impairment and hepatocarcinogenesis.
Honma Y, Miyagawa K, Hara Y, Hayashi T, Kusanaga M, Ogino N, Minami S, Oe S, Ikeda M, Hino K, Harada M．
Medical molecular morphology, Jun. 2021, Reviewed, Null - Type 4B hereditary hemochromatosis due to heterozygous p.D157A mutation in SLC40A1 complicated with hypopituitarism.
Honma Y, Karasuyama T, Kumamoto K, Shimajiri S, Toki Y, Tatsumi Y, Sumida K, Koikawa K, Morino K, Oe S, Miyagawa K, Yamasaki M, Shibata M, Abe S, Ikuta K, Hayashi H, Harada M
Medical molecular morphology, Mar. 2021, Reviewed, Null - Role of HO-1 against saturated fatty acid-induced oxidative stress in hepatocytes.
Ogino N, Miyagawa K, Nagaoka K, Matsuura-Harada Y, Ogino S, Kusanaga M, Oe S, Honma Y, Harada M, Eitoku M, Suganuma N, Ogino K
Nutrients, Mar. 2021, Reviewed, Null - C-reactive protein can predict dose intensity, time to treatment failure and overall survival in HCC treated with lenvatinib.
Hayashi T, Shibata M, Oe S, Miyagawa K, Honma Y, Harada M.
PloS one, Dec. 2020, Reviewed, Null - Endoscopic injection sclerotherapy improves liver function compared with endoscopic variceal ligation.
Hayashi T, Watanabe T, Shibata M, Kumei S, Oe S, Miyagawa K, Honma Y, Harada M.
Scientific Reports, Oct. 2021, Reviewed, Null - Child-Pugh grade deterioration stratified by the etiology after transcatheter arterial chemoembolization as initial treatment for hepatocellular carcinoma.
Yoshitomi K, Hayashi T, Oe S, Shibata M, Honma Y, Harada M, Kooka Y
Scientific reports, Feb. 2024, Reviewed, Null - Hepatitis A complicated with acute renal failure and high hepatocyte growth factor: A case report.
Oe Shinji, Shibata Michihiko, Miyagawa Koichiro, Honma Yuichi, Hiura Masaaki, Abe Shintaro, Harada Masaru
World journal of gastroenterology, Aug. 2015, Reviewed, Null
Lead - Airborne fine particulate matter in Japan induces lipid synthesis and inhibits autophagy in HepG2 cells.
Ogino N, Miyagawa K, Nagaoka K, Sumida K, Kusanaga M, Oe S, Honma Y, Shibata M, Harada M, Suganuma N, Ogino K
The international journal of biochemistry & cell biology, Dec. 2021, Reviewed, Null
