Dec. 2023
公益財団法人臨床研究奨励基金, 令和5年度 日本人海外研修助成

Oct. 2016
産業医科大学, 第34回産業医科大学学会 優秀ポスター賞

Nov. 2015
日本薬理学会, 第68回日本薬理学会西南部会 優秀発表賞（YIA）

Aug. 2011
日本産科婦人科学会, 第63回日本産科婦人科学会学術講演会 グッドプレゼンテーション賞

2,5-Dimethylcelecoxib inhibits lung fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis.
Toshiki Morimoto; Shin Ishikane; Masaki Arioka; Kohei Hashimoto; Kazunobu Igawa; Yasuyuki Higashi; Taisuke Tomonaga; Chinatsu Nishida; Kazuhiro Yatera; Fumi Takahashi-Yanaga
Respiratory investigation, May 2026, Reviewed, No invitation
Corresponding

Postoperative administration of 2,5-dimethylcelecoxib attenuates ischemia-reperfusion injury-induced cardiac dysfunction.
Shin Ishikane; Takehiro Kishigami; Eigo Ikushima; Masaki Arioka; Kazunobu Igawa; Fumi Takahashi-Yanaga
Journal of pharmacological sciences, Mar. 2026, Reviewed, No invitation
Lead, Corresponding

Adult leptomeningeal vestigial neural crest-derived multipotent cells promote vascular repair after stroke.
Yoshihiko Nakamura; Takafumi Nakano; Lluis Alzamora-Llull; Ji-Hyun Park; Masayoshi Tanaka; Ester Licastro; Damian Panas; Shin Ishikane; Dong-Bin Back; Gen Hamanaka; Wenlu Li; Elga Esposito; Yi Zheng; Bum Ju Ahn; Violeta Durán-Laforet; Rakhi Desai; Ikbal Sencan; Klaus Van Leyen; Sava Sakadžić; Evan Y Snyder; Marcin Tabaka; Kazuhide Hayakawa
Cell reports, Dec. 2025, Reviewed, No invitation

Extracellular vesicles and mitochondria in central nervous system diseases
Ji Hyun Park; Dong Bin Back; Gen Hamanaka; Shin Ishikane; Kazuhide Hayakawa
Journal of Cerebral Blood Flow & Metabolism, Dec. 2025, Reviewed, No invitation

Protocol for mitochondria lipid encapsulation using a dual-tube system for mitochondria transfer therapy
Gen Hamanaka; Dong Bin Back; Ester Licastro; Shin Ishikane; Takafumi Nakano; Kazuhide Hayakawa
STAR Protocols, Dec. 2025, Reviewed, No invitation

Unlocking extracellular mitochondria from bench to clinical application in stroke
Gen Hamanaka; Dong-Bin Back; Ji-Hyun Park; Shin Ishikane; Kazuhide Hayakawa
Stem Cells Translational Medicine, Nov. 2025, Reviewed, No invitation

Age-associated T cell immunity decreases circulating endothelial progenitor cells
Fang Zhang; Qiuchen Zhao; Shuzhen Guo; Gen Hamanaka; Dong-Bin Back; Shin Ishikane; Ester Licastro; Ji-Hyun Park; Wenlu Li; Elga Esposito; Ksenia V Kastanenka; Brian J Bacskai; Kazuhide Hayakawa
Stem Cells, Oct. 2025, Reviewed, No invitation

Celecoxib inhibits skin fibrosis via suppressing adipocyte progenitor-myofibroblast transdifferentiation by attenuating the YAP/TAZ signaling pathway.
Masaki Arioka; Hiroaki Matsunaga; Shin Ishikane; Kazuma Ito; Kohei Hashimoto; Yi Wang; Kazunobu Igawa; Fumi Takahashi-Yanaga
Life sciences, Oct. 2025, Reviewed, No invitation

Therapeutic mitochondria treatment amplifies macrophage-mediated phagocytosis and recycling exocytosis
Masayoshi Tanaka; Shin Ishikane; Dong Bin Back; Ester Licastro; Fang Zhang; Ji Hyun Park; Elga Esposito; Giuseppe Pignataro; Takafumi Nakano; Yoshihiko Nakamura; Kazuhide Hayakawa
Journal of Cerebral Blood Flow & Metabolism, Mar. 2025, Reviewed, No invitation

Differentiation-inducing factor-1 inhibits EMT by proteasomal degradation of TAZ and YAP in cervical and colon cancer cell lines.
Masaki Arioka; Wang Yi; Kazunobu Igawa; Shin Ishikane; Fumi Takahashi-Yanaga
European journal of pharmacology, Jan. 2025, Reviewed, No invitation

2,5-Dimethyl-celecoxib induces early termination of inflammatory responses by transient macrophage accumulation and inhibits the progression of cardiac remodeling in a mouse model of cryoinjury-induced myocardial infarction.
Takehiro Kishigami; Shin Ishikane; Masaki Arioka; Kazunobu Igawa; Yosuke Nishimura; Fumi Takahashi-Yanaga
Journal of pharmacological sciences, Feb. 2024, Reviewed, No invitation
Corresponding

Differentiation-inducing factor-1 reduces lipopolysaccharide-induced vascular cell adhesion molecule-1 by suppressing mTORC1-S6K signaling in vascular endothelial cells.
Masaki Arioka; Fumi Seto-Tetsuo; Takeru Inoue; Koichi Miura; Shin Ishikane; Kazunobu Igawa; Katsuhiko Tomooka; Fumi Takahashi-Yanaga; Toshiyuki Sasaguri
Life sciences, Dec. 2023, Reviewed

Promising small molecule anti-fibrotic agents: Newly developed or repositioned drugs targeting myofibroblast transdifferentiation.
Shin Ishikane; Masaki Arioka; Fumi Takahashi-Yanaga
Biochemical pharmacology, Aug. 2023, Reviewed, Invited
Lead

Increased risk of metastasis in patients with incidental use of renin-angiotensin system inhibitors: a retrospective analysis for multiple types of cancer based on electronic medical records.
Akie Hirata; Shin Ishikane; Fumi Takahashi-Yanaga; Masaki Arioka; Tasuku Okui; Chinatsu Nojiri; Toshiyuki Sasaguri; Naoki Nakashima
Hypertension research : official journal of the Japanese Society of Hypertension, Dec. 2022, Reviewed, No invitation

2,5-Dimethylcelecoxib attenuates cardiac fibrosis caused by cryoinjury-induced myocardial infarction by suppressing the fibroblast-to-myofibroblast transformation via inhibition of the TGF-β signaling pathway.
Eigo Ikushima; Shin Ishikane; Takehiro Kishigami; Hiroaki Matsunaga; Kazunobu Igawa; Katsuhiko Tomooka; Yosuke Nishimura; Fumi Takahashi-Yanaga
Biochemical pharmacology, Mar. 2022, Reviewed, No invitation

Differentiation-inducing factor-1 potentiates adipogenic differentiation and attenuates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells.
Shin Ishikane; Eigo Ikushima; Kazunobu Igawa; Katsuhiko Tomooka; Fumi Takahashi-Yanaga
Biochimica et biophysica acta. Molecular cell research, Feb. 2021

Development of a novel and rapid measurement system for growth differentiation factor-15, progranulin, and osteopontin in uterine sarcoma.
Mitsuo Maeno; Tetsuya Mizutani; Hideaki Tsuyoshi; Shizuka Yamada; Shin Ishikane; Shinya Kawabe; Kengo Nishimura; Masami Yamada; Kaoru Miyamoto; Yoshio Yoshida
Endocrine journal, Jan. 2020, Reviewed

2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation.
Shoji Morishige; Fumi Takahashi-Yanaga; Shin Ishikane; Masaki Arioka; Kazunobu Igawa; Akihiro Kuroo; Katsuhiko Tomooka; Akira Shiose; Toshiyuki Sasaguri
Biochemical pharmacology, Oct. 2019, Reviewed, No invitation

Angiotensin II promotes pulmonary metastasis of melanoma through the activation of adhesion molecules in vascular endothelial cells.
Shin Ishikane; Hiroshi Hosoda; Takashi Nojiri; Takeshi Tokudome; Tetsuya Mizutani; Koichi Miura; Yoshiharu Akitake; Toru Kimura; Yoshitaka Imamichi; Shinya Kawabe; Yumiko Toyohira; Nobuyuki Yanagihara; Fumi Takahashi-Yanaga; Mikiya Miyazato; Kaoru Miyamoto; Kenji Kangawa
Biochemical pharmacology, Aug. 2018, Reviewed, No invitation
Lead

The role of angiotensin II in cancer metastasis: Potential of renin-angiotensin system blockade as a treatment for cancer metastasis.
Shin Ishikane; Fumi Takahashi-Yanaga
Biochemical pharmacology, May 2018, Reviewed, Invited
Lead, Corresponding

Inhibitory effects of pine nodule extract and its component, SJ-2, on acetylcholine-induced catecholamine secretion and synthesis in bovine adrenal medullary cells.
Xiaojia Li; Takafumi Horishita; Yumiko Toyohira; Hui Shao; Jie Bai; Haixia Bo; Xinbo Song; Shin Ishikane; Yukari Yoshinaga; Noriaki Satoh; Masato Tsutsui; Nobuyuki Yanagihara
Journal of pharmacological sciences, Apr. 2017, Reviewed, No invitation

Establishment and characterization of a novel orthotopic mouse model for human uterine sarcoma with different metastatic potentials.
Shinya Kawabe; Tetsuya Mizutani; Shin Ishikane; Miguel Ernesto Martinez; Yasushi Kiyono; Koichi Miura; Hiroshi Hosoda; Yoshitaka Imamichi; Kenji Kangawa; Kaoru Miyamoto; Yoshio Yoshida
Cancer letters, Oct. 2015, Reviewed, No invitation

Identification of novel steroidogenic factor 1 (SF-1)-target genes and components of the SF-1 nuclear complex.
Tetsuya Mizutani; Shinya Kawabe; Shin Ishikane; Yoshitaka Imamichi; Akihiro Umezawa; Kaoru Miyamoto
Molecular and cellular endocrinology, Jun. 2015, Reviewed

Protective effects of C-type natriuretic peptide on cisplatin-induced nephrotoxicity in mice.
Toru Kimura; Takashi Nojiri; Hiroshi Hosoda; Shin Ishikane; Yasushi Shintani; Masayoshi Inoue; Mikiya Miyazato; Meinoshin Okumura; Kenji Kangawa
Cancer chemotherapy and pharmacology, May 2015, Reviewed

C-type natriuretic peptide attenuates lipopolysaccharide-induced acute lung injury in mice.
Toru Kimura; Takashi Nojiri; Hiroshi Hosoda; Shin Ishikane; Yasushi Shintani; Masayoshi Inoue; Mikiya Miyazato; Meinoshin Okumura; Kenji Kangawa
The Journal of surgical research, Apr. 2015, Reviewed

Atrial natriuretic peptide protects against cisplatin-induced acute kidney injury.
Takashi Nojiri; Hiroshi Hosoda; Toru Kimura; Koichi Miura; Shin Ishikane; Takeshi Tokudome; Yasushi Shintani; Masayoshi Inoue; Mikiya Miyazato; Meinoshin Okumura; Kenji Kangawa
Cancer chemotherapy and pharmacology, Jan. 2015, Reviewed

Transcriptional regulation of genes related to progesterone production.
Tetsuya Mizutani; Shin Ishikane; Shinya Kawabe; Akihiro Umezawa; Kaoru Miyamoto
Endocrine journal, 2015, Reviewed

Atrial natriuretic peptide inhibits lipopolysaccharide-induced acute lung injury.
Takashi Nojiri; Hiroshi Hosoda; Takeshi Tokudome; Koichi Miura; Shin Ishikane; Toru Kimura; Yasushi Shintani; Masayoshi Inoue; Noriyoshi Sawabata; Mikiya Miyazato; Meinoshin Okumura; Kenji Kangawa
Pulmonary pharmacology & therapeutics, Oct. 2014, Reviewed

C/EBPβ (CCAAT/enhancer-binding protein β) mediates progesterone production through transcriptional regulation in co-operation with SF-1 (steroidogenic factor-1).
Tetsuya Mizutani; Yunfeng Ju; Yoshitaka Imamichi; Tsukasa Osaki; Takashi Yazawa; Shinya Kawabe; Shin Ishikane; Takehiro Matsumura; Masafumi Kanno; Yasue Kamiki; Kohei Kimura; Naoto Minamino; Kaoru Miyamoto
The Biochemical journal, Jun. 2014, Reviewed

Comparison of angiogenic, cytoprotective, and immunosuppressive properties of human amnion- and chorion-derived mesenchymal stem cells.
Kenichi Yamahara; Kazuhiko Harada; Makiko Ohshima; Shin Ishikane; Shunsuke Ohnishi; Hidetoshi Tsuda; Kentaro Otani; Akihiko Taguchi; Toshihiro Soma; Hiroyasu Ogawa; Shinji Katsuragi; Jun Yoshimatsu; Mariko Harada-Shiba; Kenji Kangawa; Tomoaki Ikeda
PloS one, 2014, Reviewed, No invitation

Allogeneic transplantation of fetal membrane-derived mesenchymal stem cell sheets increases neovascularization and improves cardiac function after myocardial infarction in rats.
Shin Ishikane; Hiroshi Hosoda; Kenichi Yamahara; Yoshiharu Akitake; Jung Kyoungsook; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara; Mikiya Miyazato; Kenji Kangawa; Tomoaki Ikeda
Transplantation, Oct. 2013, Reviewed, No invitation
Lead

Injection of specific amyloid-beta oligomers (beta₁₋₄₀:beta₁₋₄₂ = 10:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis.
Mehmet Bülent Ozdemir; Cagdas Erdogan; Katsunori Iwasaki; Takuya Watanabe; Shin Ishikane; Michihiro Fujiwara
Neurological research, Oct. 2013, Reviewed

Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis.
Makiko Ohshima; Kenichi Yamahara; Shin Ishikane; Kazuhiko Harada; Hidetoshi Tsuda; Kentaro Otani; Akihiko Taguchi; Mikiya Miyazato; Shinji Katsuragi; Jun Yoshimatsu; Makoto Kodama; Kenji Kangawa; Tomoaki Ikeda
Journal of molecular and cellular cardiology, Sep. 2012, Reviewed, No invitation

Allogeneic transplantation of fetal membrane-derived mesenchymal stem cells: Therapy for acute myocarditis
Shin Ishikane; Hiroshi Hosoda; Kenichi Yamahara; Makoto Kodama; Tomoaki Ikeda
Stem Cells and Cancer Stem Cells, Volume 2: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 2, Jan. 2012, Reviewed, No invitation
Lead, Corresponding

Allogeneic administration of fetal membrane-derived mesenchymal stem cells attenuates acute myocarditis in rats.
Shin Ishikane; Kenichi Yamahara; Masaharu Sada; Kazuhiko Harada; Makoto Kodama; Hatsue Ishibashi-Ueda; Kazuhide Hayakawa; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara; Kenji Kangawa; Tomoaki Ikeda
Journal of molecular and cellular cardiology, Nov. 2010, Reviewed, No invitation
Lead

Allogenic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritis.
Hidetoshi Tsuda; Kenichi Yamahara; Shin Ishikane; Kentaro Otani; Atsuhiro Nakamura; Kazutomo Sawai; Naotsugu Ichimaru; Masaharu Sada; Akihiko Taguchi; Hiroshi Hosoda; Masahiro Tsuji; Hiroshi Kawachi; Masaru Horio; Yoshitaka Isaka; Kenji Kangawa; Shiro Takahara; Tomoaki Ikeda
American journal of physiology. Renal physiology, Nov. 2010, Reviewed

Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism.
Kazuhide Hayakawa; Keiichi Irie; Kazunori Sano; Takuya Watanabe; Sei Higuchi; Makiko Enoki; Takafumi Nakano; Kazuhiko Harada; Shin Ishikane; Tomoaki Ikeda; Masayuki Fujioka; Kensuke Orito; Katsunori Iwasaki; Kenichi Mishima; Michihiro Fujiwara
Biological & pharmaceutical bulletin, Sep. 2009, Reviewed

Involvement of tazarotene-induced gene 1 in proliferation and differentiation of human adipose tissue-derived mesenchymal stem cells
Ohnishi, S.; Okabe, K.; Obata, H.; Otani, K.; Ishikane, S.; Ogino, H.; Kitamura, S.; Nagaya, N.
Cell Proliferation, 2009, Reviewed, No invitation

Therapeutic Potential of Mesenchymal Stem Cells Derived from Three Different Layers of Human Fetal Membrane In Hindlimb Ischemia Model
Kazuhiko Harada; Shunsuke Ohnishi; Kenichi Yamahara; Masaharu Sada; Shin Ishikane; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara; Kenji Kangawa; Soichiro Kitamura; Noritoshl Nagaya; Tomoaki Ikeda
CIRCULATION, Oct. 2008, Reviewed, No invitation

Allogeneic injection of fetal membrane-derived mesenchymal stem cells induces therapeutic angiogenesis in a rat model of hind limb ischemia.
Shin Ishikane; Shunsuke Ohnishi; Kenichi Yamahara; Masaharu Sada; Kazuhiko Harada; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara; Soichiro Kitamura; Noritoshi Nagaya; Tomoaki Ikeda
Stem cells (Dayton, Ohio), Oct. 2008, Reviewed, No invitation
Lead

Paracrine cytoprotective effects of inner chorion-derived human mesenchymal stem cells
Kazuhiko Harada; Noritoshi Nagaya; Shunsuke Ohnishi; Shin Ishikane; Michihiro Fujiwara; Tomoaki Ikeda
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Mar. 2008, Reviewed, No invitation

Spatial Memory Impairment Without Apoptosis Induced by the Combination of Beta-Amyloid Oligomers and Cerebral Ischemia Is Related to Decreased Acetylcholine Release in Rats
Takuya Watanabe; Katsunori Iwasaki; Shin Ishikane; Tetsuya Naitou; Yoshitaka Yoshimitsu; Norito Yamagata; Mehmeto Bülent Ozdemir; Kotaro Takasaki; Nobuaki Egashira; Kenichi Mishima; Michihiro Fujiwara
Journal of Pharmacological Sciences, 2008, Reviewed, No invitation

蛋白尿改善を目指したイオンチャネル阻害剤の開発と評価
坂口怜子, 松田由宗, 岡田亮, 石兼真, 高橋富美, 片渕瑛介, 中山敏幸, 眞田賢哉 上田陽一, 木原隆典, 永田龍, 森誠之
Journal of UOEH, Mar. 2024, Reviewed, Null

昇圧ペプチドangiotensin IIによる血行性癌転移増悪機構の解明と臨床応用に向けた新規癌転移抑制療法の開発
石兼 真
医科学応用研究財団研究報告, Feb. 2020, Null, Null
Lead

アンギオテンシンIIによる血管内皮細胞を介した血行性癌転移増悪機構の解明
石兼 真, 細田 洋司, 野尻 崇, 徳留 健, 水谷 哲也, 河邉 真也, 今道 力敬, 豊平 由美子, 柳原 延章, 宮里 幹也, 宮本 薫, 寒川 賢治
日本内分泌学会雑誌, Apr. 2016, Null, Null
Lead

婦人科領域と関連のある自律神経研究 自律神経調節の基礎と臨床　植物由来フラボノイドと更年期障害について
柳原 延章, 石 明寛, 豊平 由美子, 李 暁佳, 石兼 真, 佐藤 教昭, 後藤 幸生
日本女性医学学会雑誌, Oct. 2016, Null, Null

婦人科領域と関連のある自律神経研究 自律神経調節の基礎と臨床　植物由来フラボノイドと更年期障害について
柳原 延章, 佐藤 教昭, 豊平 由美子, 李 暁佳, 石兼 真, 石 明寛, 後藤 幸生
日本女性医学学会雑誌, Apr. 2017, Null, Null

DIF-1は循環腫瘍細胞の血管壁への接着を抑制することで抗転移効果を発揮する(DIF-1 exerted anti-metastatic effects via suppressing circulating tumor cell adhesion to blood vessels)
有岡 将基, 笹栗 俊之, 石兼 真, 高橋 富美
日本癌学会総会記事, Sep. 2022, Reviewed, Null

ジメチルセレコキシブの心筋障害後の線維化におけるマクロファージへの影響
岸上 赳大, 石兼 真, 西村 陽介, 高橋 富美
日本胸部外科学会定期学術集会, Oct. 2022, Not reviewed, No invitation

虚血再灌流障害に伴う心臓リモデリングに対する2,5-ジメチルセレコキシブの抑制効果
石兼 真, 岸上 赳大, 有岡 将基, 高橋 富美
産業医科大学雑誌, Mar. 2023, Null, Null
Lead, Corresponding

昇圧ペプチドangiotensin IIによる血行性癌転移増悪機構の解明
石兼 真, 細田 洋司, 野尻 崇, 徳留 健, 水谷 哲也, 李 暁佳, 豊平 由美子, 宮里 幹也, 宮本 薫, 柳原 延章, 寒川 賢治
産業医科大学雑誌, Mar. 2017, Null, Null
Lead

植物由来化合物によるカテコールアミン動態に及ぼす影響
李 暁佳, 豊平 由美子, 堀下 貴文, 石兼 真, 吉永 有香里, 柳原 延章
産業医科大学雑誌, Mar. 2017, Null, Null

培養ウシ副腎髄質細胞におけるカテコールアミン生合成・分泌に及ぼす柑橘類フィトケミカルの影響
長友 逸郎, 小代 麻由, 豊平 由美子, 李 暁佳, 吉永 有香里, 石兼 真, 柳原 延章
産業医科大学雑誌, Mar. 2017, Null, Null

昇圧ペプチドangiotensin IIによる血管内皮細胞を介した血行性癌転移増悪機構の解明
石兼 真, 細田 洋司, 野尻 崇, 徳留 健, 水谷 哲也, 豊平 由美子, 宮里 幹也, 宮本 薫, 寒川 賢治, 高橋 富美
臨床薬理, Nov. 2017, Null, Null
Lead

柑橘類機能成分のカテコールアミン動態に及ぼす影響
豊平 由美子, 坂巻 路可, 李 暁佳, 吉永 有香里, 石兼 真, 柳原 延章
血管, Jan. 2017, Null, Null

淫羊かく成分イカリソサイドAのカテコールアミン分泌及び生合成の抑制作用
李 暁佳, 豊平 由美子, 堀下 貴文, 石兼 真, 吉永 有香里, 佐藤 教昭, 上野 晋, 筒井 正人, 柳原 延章
血管, Jan. 2017, Null, Null

昇圧ペプチドangiotensin IIによる血管内皮細胞を介した血行性癌転移調節機序
石兼 真, 細田 洋司, 野尻 崇, 徳留 健, 水谷 哲也, 李 暁佳, 豊平 由美子, 宮里 幹也, 宮本 薫, 柳原 延章, 寒川 賢治
血管, Jan. 2017, Null, Null

Allogeneic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritis
Hidetoshi Tsuda, Kenichi Yamahara, Shin Ishikane, Kentaro Otani, Atsuhiro Nakamura, Kazutomo Sawai, Naotsugu Ichimaru, Masaharu Sada, Akihiko Taguchi, Hiroshi Hosoda, Masahiro Tsuji, Hiroshi Kawachi, Masaru Horio, Yoshitake Isaka, Kenji Kangawa, Shiro Takahara, Tomoaki Ikeda
American Journal of Physiology-Renal Physiology, Oct. 2010, Reviewed, No invitation

Angiotensin II promotes pulmonary metastasis of melanoma through the activation of adhesion molecules in vascular endothelial cells
Shin Ishikane, Hiroshi Hosoda, Takashi Nojiri, Takeshi Tokudome, Tetsuya Mizutani, Koichi Miura, Yoshiharu Akitake, Toru Kimura, Yoshitaka Imamichi, Shinya Kawabe, Yumiko Toyohira, Nobuyuki Yanagihara, Fumi Takahashi–Yanaga, Mikiya Miyazato, Kaoru Miyamoto, Kenji Kangawa
Biochemical Pharmacology, Apr. 2018, Reviewed, No invitation
Lead

The role of angiotensin II in cancer metastasis: Potential of renin-angiotensin system blockade as a treatment for cancer metastasis.
Shin Ishikane, Fumi Takahashi-Yanaga.
Biochemical Pharmacology, Mar. 2018, Reviewed, No invitation
Lead, Corresponding

Promising small molecule anti-fibrotic agents: Newly developed or repositioned drugs targeting myofibroblast transdifferentiation.
石兼真, 有岡将基, 高橋富美
Biochemical pharmacology, Aug. 2023, Reviewed, Null
Lead

2,5-Dimethylcelecoxib attenuates cardiac fibrosis caused by cryoinjury-induced myocardial infarction by suppressing the fibroblast-to-myofibroblast transformation via inhibition of the TGF-β signaling pathway.
Ikushima Eigo, Ishikane Shin, Kishigami Takehiro, Matsunaga Hiroaki, Igawa Kazunobu, Tomooka Katsuhiko, Nishimura Yosuke, Takahashi-Yanaga Fumi
Biochemical pharmacology, Mar. 2022, Reviewed, No invitation

2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation.
Morishige Shoji, Takahashi-Yanaga Fumi, Ishikane Shin, Arioka Masaki, Igawa Kazunobu, Kuroo Akihiro, Tomooka Katsuhiko, Shiose Akira, Sasaguri Toshiyuki
Biochemical pharmacology, Jun. 2019, Reviewed, Null

Angiotensin II promotes pulmonary metastasis of melanoma through the activation of adhesion molecules in vascular endothelial cells.
Ishikane Shin, Hosoda Hiroshi, Nojiri Takashi, Tokudome Takeshi, Mizutani Tetsuya, Miura Koichi, Akitake Yoshiharu, Kimura Toru, Imamichi Yoshitaka, Kawabe Shinya, Toyohira Yumiko, Yanagihara Nobuyuki, Takahashi-Yanaga Fumi, Miyazato Mikiya, Miyamoto Kaoru, Kangawa Kenji
Biochemical pharmacology, Aug. 2018, Reviewed, Null
Lead

Differentiation-inducing factor-1 potentiates adipogenic differentiation and attenuates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells.
Ishikane Shin, Ikushima Eigo, Igawa Kazunobu, Tomooka Katsuhiko, Takahashi-Yanaga Fumi
Biochimica et biophysica acta. Molecular cell research, Feb. 2021, Reviewed, No invitation
Lead, Corresponding

C/EBPβ (CCAAT/enhancer-binding protein β) mediates progesterone production through transcriptional regulation in co-operation with SF-1 (steroidogenic factor-1)
Teysuya Mizutani, Yunfeng Ju, Yoshitaka Imamichi, Tsukasa Osaki, Takashi Yazawa, Shinya Kawabe, Shin Ishikane, Takehiko Matsumura, Masafumi Kanno, Yasue Kamiki, Kohei Kimura, Naoto Minamino, Kaoru Miyamoto
Biochmical journal, 2014, Reviewed, No invitation

Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism
Kazuhide Hayakawa, Keiichi Irie, Kazunori Sano, Takuya Watanabe, Sei Higuchi, Makiko Enoki, Takafumi Nakano, Kazuhiko Harada, Shin Ishikane, Tomoaki Ikeda, Masayuki Fujioka, Kensuke Orito, Katsunori Iwasaki, Kenichi Mishima, Michihiro Fujiwara
Biological & Pharmaceutical Bulletin, 2009, Reviewed, No invitation

Protective effects of C-type natriuretic peptide on cisplatin-induced nephrotoxicity in mice.
Kimura Toru, Nojiri Takashi, Hosoda Hiroshi, Ishikane Shin, Shintani Yasushi, Inoue Masayoshi, Miyazato Mikiya, Okumura Meinoshin, Kangawa Kenji
Cancer chemotherapy and pharmacology, May 2015, Reviewed, Null

Atrial natriuretic peptide protects against cisplatin-induced acute kidney injury.
Nojiri Takashi, Hosoda Hiroshi, Kimura Toru, Miura Koichi, Ishikane Shin, Tokudome Takeshi, Shintani Yasushi, Inoue Masayoshi, Miyazato Mikiya, Okumura Meinoshin, Kangawa Kenji
Cancer chemotherapy and pharmacology, Jan. 2015, Reviewed, Null

Establishment and characterization of a novel orthotopic mouse model for human uterine sarcoma with different metastatic potentials.
Kawabe Shinya, Mizutani Tetsuya, Ishikane Shin, Martinez Miguel Ernesto, Kiyono Yasushi, Miura Koichi, Hosoda Hiroshi, Imamichi Yoshitaka, Kangawa Kenji, Miyamoto Kaoru, Yoshida Yoshio
Cancer letters, Oct. 2015, Reviewed, Null

Involvement of tazarotene-induced gene 1 in proliferation and differentiation of human adipose tissue-derived mesenchymal stem cells
Ohnishi Shunsuke, Kohta Okabe, Hiroaki Obata, Kentaro Otani, Shin Ishikane, Hitoshi Ogino, Soichiro Kitamura, Noritoshi Nagaya
Cell Proliferation, 2009, Reviewed, No invitation

Development of a novel and rapid measurement system for growth differentiation factor-15, progranulin, and osteopontin in uterine sarcoma.
Maeno Mitsuo, Mizutani Tetsuya, Tsuyoshi Hideaki, Yamada Shizuka, Ishikane Shin, Kawabe Shinya, Nishimura Kengo, Yamada Masami, Miyamoto Kaoru, Yoshida Yoshio
Endocrine journal, Jan. 2020, Reviewed, Null

Transcriptional regulation of genes related to progesterone production.
Mizutani Tetsuya, Ishikane Shin, Kawabe Shinya, Umezawa Akihiro, Miyamoto Kaoru
Endocrine journal, 2015, Reviewed, Null

Angiotensin II promotes primary tumor growth and metastasis formation of murine TNBC 4T1 cells through the fibroblasts around cancer cells.
Takiguchi Tomohiro, Takahashi-Yanaga Fumi, Ishikane Shin, Tetsuo Fumi, Hosoda Hiroshi, Arioka Masaki, Kitazono Takanari, Sasaguri Toshiyuki
European journal of pharmacology, Oct. 2021, Reviewed, No invitation

Increased risk of metastasis in patients with incidental use of renin-angiotensin system inhibitors: a retrospective analysis for multiple types of cancer based on electronic medical records.
Hirata Akie, Ishikane Shin, Takahashi-Yanaga Fumi, Arioka Masaki, Okui Tasuku, Nojiri Chinatsu, Sasaguri Toshiyuki, Nakashima Naoki
Hypertension research : official journal of the Japanese Society of Hypertension, Dec. 2022, Reviewed, Null

Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis
Makiko Ohshima, Kenichi Yamahara, Shin Ishikane, Kazuhiko Harada, Hidetoshi Tsuda, Kentaro Otani, Akihiko Taguchi, Miakiya Miyazato, Shinji Katsuragi, Jun Yoshimatsu, Makoto Kodama, Kenji Kangawa, Tomoaki Ikeda
Journal of Molecular and Cellular Cardiology, 2012, Reviewed, No invitation

Allogeneic administration of fetal membrane-derived mesenchymal stem cells attenuates acute myocarditis in rats
Shin Ishikane, Kenichi Yamahara, Masaharu Sada, Kazuhiko Harada, Makoto Kodama, Hatsue Ishibashi-Ueda, Kazuhide Hawakawa, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara, Kenji Kangawa, Tomoaki Ikeda
Journal of Molecular and Cellular Cardiology, 2010, Reviewed, No invitation

Angiotensin IIは血管内皮細胞接着経路を介して癌肺転移を増悪させる(Angiotensin II increases tumor lung metastasis through vascular endothelial cell adherent pathway)
Ishikane Shin, Hosoda Hiroshi, Nojiri Takashi, Tokudome Takeshi, Mizutani Tetsuya, Imamichi Yoshitaka, Kawabe Shinya, Toyohira Yumiko, Yanagihara Nobuyuki, Miyazato Mikiya, Miyamoto Kaoru, Kangawa Kenji
Journal of Pharmacological Sciences, Mar. 2016, Null, Null
Lead

培養ウシ副腎髄質細胞においてflavone類のapigeninおよびluteolinがcatecholamine分泌およびtyrosine hydroxylaseに及ぼす作用(Effects of flavones, apigenin and luteolin, on catecholamine secretion and tyrosine hydroxylase in cultured bovine adrenal medullary cells)
Toyohira Yumiko, Li Xiaojia, Yoshinaga Yukari, Baba Hiroka, Matsuda Yuki, Ishikane Shin, Yanagihara Nobuyuki
Journal of Pharmacological Sciences, Mar. 2016, Null, Null

Spatial memory impairment without apoptosis induced by the combination of A oligomers and cerebral ischemia is related to decreased acetylcholine release in rats
Takuya Watanabe, Katsunori Iwasaki, Shin Ishikane, Tetsuya Naitou, Yoshitaka Yoshimitsu, Norito Yamagata, Mehmeto Buülent Ozdemir, Kotaro Takasaki, Nobuaki Egashira, Kenichi Mishima, Michihiro Fujiwara
Journal of Pharmacological Sciences, 2008, Reviewed, No invitation

2,5-Dimethyl-celecoxib induces early termination of inflammatory responses by transient macrophage accumulation and inhibits the progression of cardiac remodeling in a mouse model of cryoinjury-induced myocardial infarction.
Kishigami Takehiro, Ishikane Shin, Arioka Masaki, Igawa Kazunobu, Nishimura Yosuke, Takahashi-Yanaga Fumi
Journal of pharmacological sciences, Feb. 2024, Reviewed, No invitation
Corresponding

Inhibitory effects of pine nodule extract and its component, SJ-2, on acetylcholine-induced catecholamine secretion and synthesis in bovine adrenal medullary cells.
Li Xiaojia, Horishita Takafumi, Toyohira Yumiko, Shao Hui, Bai Jie, Bo Haixia, Song Xinbo, Ishikane Shin, Yoshinaga Yukari, Satoh Noriaki, Tsutsui Masato, Yanagihara Nobuyuki
Journal of pharmacological sciences, Apr. 2017, Reviewed, Null

C-type natriuretic peptide attenuates lipopolysaccharide-induced acute lung injury in mice.
Kimura Toru, Nojiri Takashi, Hosoda Hiroshi, Ishikane Shin, Shintani Yasushi, Inoue Masayoshi, Miyazato Mikiya, Okumura Meinoshin, Kangawa Kenji
The Journal of surgical research, Apr. 2015, Reviewed, Null

Differentiation-inducing factor-1 reduces lipopolysaccharide-induced vascular cell adhesion molecule-1 by suppressing mTORC1-S6K signaling in vascular endothelial cells.
Arioka Masaki, Seto-Tetsuo Fumi, Inoue Takeru, Miura Koichi, Ishikane Shin, Igawa Kazunobu, Tomooka Katsuhiko, Takahashi-Yanaga Fumi, Sasaguri Toshiyuki
Life sciences, Dec. 2023, Reviewed, Null

Identification of novel steroidogenic factor 1 (SF-1)-target genes and components of the SF-1 nuclear complex.
Mizutani Tetsuya, Kawabe Shinya, Ishikane Shin, Imamichi Yoshitaka, Umezawa Akihiro, Miyamoto Kaoru
Molecular and cellular endocrinology, Jun. 2015, Reviewed, Null

Injection of specific amyloid-beta oligomers (beta1-40:beta1-42 = 10:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis
Mehmet Bülent Özdemir, Cagdas Erdogan, Katsunori Iwasaki, Takuya Watanabe, Shin Ishikane, Michihiro Fujiwara
Neurological Research, 2013, Reviewed, No invitation

Comparison of Angiogenic, Cytoprotective, and Immunosuppressive Properties of Human Amnion- and Chorion-Derived Mesenchymal Stem Cells
Kenichi Yamahara, Kazuhiko Harada, Makiko Ohshima, Shin Ishikane, Shunsuke Ohnishi, Hidetoshi Tsuda, Kentaro Otani, Akihiko Taguchi, Toshihiro Soma, Hiroyasu Ogawa, Shinji Katsuragi, Jun Yoshimatsu, Mariko Harada-Shiba, Kenji Kangawa, Tomoaki Ikeda
Plos One, 2014, Reviewed, No invitation

Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.
Nojiri Takashi, Hosoda Hiroshi, Tokudome Takeshi, Miura Koichi, Ishikane Shin, Otani Kentaro, Kishimoto Ichiro, Shintani Yasushi, Inoue Masayoshi, Kimura Toru, Sawabata Noriyoshi, Minami Masato, Nakagiri Tomoyuki, Funaki Soichiro, Takeuchi Yukiyasu, Maeda Hajime, Kidoya Hiroyasu, Kiyonari Hiroshi, Shioi Go, Arai Yuji, Hasegawa Takeshi, Takakura Nobuyuki, Hori Megumi, Ohno Yuko, Miyazato Mikiya, Mochizuki Naoki, Okumura Meinoshin, Kangawa Kenji
Proceedings of the National Academy of Sciences of the United States of America, Mar. 2015, Reviewed, Null

Atrial natriuretic peptide inhibits lipopolysaccharide-induced acute lung injury
Takashi Nojiri, Hiroshi Hosoda, Takeshi Tokudome, Koichi Miura, Shin Ishikane, Toru Kimura, Yasushi Shintani, Masayoshi Inoue, Noriyoshi Sawabata, Mikiya Miyazato, Meinoshin Okumura, Kenji Kangawa
Pulumonary Pharmacology and Therapeutics, 2014, Reviewed, No invitation

Allogeneic Injection of Fetal Membrane-Derived Mesenchymal Stem Cells Induces Therapeutic Angiogenesis in a Rat Model of Hind Limb Ischemia
Shin Ishikane, Shunsuke Ohnishi, Kenichi Yamahara, Masaharu Sada, Kazuhiko Harada, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara, Soichiro Kitamura, Noritoshi Nagaya, Tomoaki Ikeda
Stem Cells, 2008, Reviewed, No invitation

Allogeneic transplantation of fetal membrane-derived mesenchymal stem cells: Therapy for acute myocarditis
Shin Ishikane, Hiroshi Hosoda, Kenichi Yamahara, Makoto Kodama, Tomoaki Ikeda
Stem Cells and Cancer Stem Cells, 2012, Reviewed, No invitation

Allogeneic transplantation of fetal membrane-derived mesenchymal stem cell sheets increases neovascularization and improves cardiac function after myocardial infarction in rats
Shin Ishikane, Hiroshi Hosoda, Kenichi Yamahara, Yoshiharu Akitake, Jung Kyoungsook, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara, Mikiya Miyazato, Kenji Kangawa,　Tomoaki Ikeda
Transplantation, 2013, Reviewed, No invitation

Corrigendum to 'Atrial natriuretic peptide inhibits lipopolysaccharide-induced acute lung injury' [Pulm. Pharmacol. Therapeut. 29/1 (2014) 24-30].
Nojiri Takashi, Hosoda Hiroshi, Tokudome Takeshi, Miura Koichi, Ishikane Shin, Kimura Toru, Shintani Yasushi, Inoue Masayoshi, Sawabata Noriyoshi, Miyazato Mikiya, Okumura Meinoshin, Kangawa Kenji
Pulmonary pharmacology & therapeutics, Aug. 2018, Null, Null

Tissue Regeneration: From Basic Biology to Clinical Application
Contributor
2012

Therapeutic application of allogeneic feral membrane-derived mesenchymal stem cell transplantation in regenerative medicine.
Shin Ishikane, Hiroshi Hosoda, Tomoaki Ikeda, Joint work
INTECH, Mar. 2012
978-953-51-0387-5