Caspase-4 deficiency impairs nuclear actin-mediated DNA double-strand break repair and increases radiosensitivity in cancer cells
Shohei Nagasaka; Tomomitsu Doi; Kunie Obayashi; Masaoki Kohzaki; Kazuhiro Sumida; Yosuke Chiba; Junkoh Yamamoto; Motoyoshi Endo
Biochemical and Biophysical Research Communications, Nov. 2025

Differential Induction of Endoplasmic Reticulum Stress Signaling by Antibody Isotypes: Implications for Plasma Cell Differentiation.
Kunie Obayashi; Tomomitsu Doi; Kazuhiro Sumida; Motoyoshi Endo
European journal of immunology, Apr. 2025

Caspase-4 promotes metastasis and interferon-γ-induced pyroptosis in lung adenocarcinoma.
Yosuke Chiba; Tomomitsu Doi; Kunie Obayashi; Kazuhiro Sumida; Shohei Nagasaka; Ke-Yong Wang; Kei Yamasaki; Katsuhiro Masago; Hirokazu Matsushita; Hiroaki Kuroda; Kazuhiro Yatera; Motoyoshi Endo
Communications biology, Jun. 2024, Reviewed

Caspase-4 has a role in cell division in epithelial cells through actin depolymerization
Kazuhiro Sumida; Tomomitsu Doi; Kunie Obayashi; Yosuke Chiba; Shohei Nagasaka; Noriyoshi Ogino; Koichiro Miyagawa; Ryoko Baba; Hiroyuki Morimoto; Hideki Hara; Takeshi Terabayashi; Toshimasa Ishizaki; Masaru Harada; Motoyoshi Endo
Biochemical and Biophysical Research Communications, Dec. 2023

ANGPTL8 links inflammation and poor differentiation, which are characteristics of malignant renal cell carcinoma.
Takuo Matsukawa; Tomomitsu Doi; Kunie Obayashi; Kazuhiro Sumida; Naohiro Fujimoto; Motoyoshi Endo
Cancer science, Dec. 2022, Reviewed

Involvement of activator protein-1 family members in β-catenin and p300 association on the genome of PANC-1 cells.
Tomomitsu Doi; Hironori Hojo; Shinsuke Ohba; Kunie Obayashi; Motoyoshi Endo; Toshimasa Ishizaki; Akira Katoh; Hiroyuki Kouji
Heliyon, Feb. 2022, Reviewed
Lead, Corresponding

Angiopoietin-like protein 2 decreases peritoneal metastasis of ovarian cancer cells by suppressing anoikis resistance.
Yuko Takeshita; Takeshi Motohara; Tsuyoshi Kadomatsu; Tomomitsu Doi; Kunie Obayashi; Yuichi Oike; Hidetaka Katabuchi; Motoyoshi Endo
Biochemical and biophysical research communications, Jul. 2021, Reviewed

Soluble PD-L1 with PD-1-binding capacity exists in the plasma of patients with non-small cell lung cancer.
Masahiro Takeuchi; Tomomitsu Doi; Kunie Obayashi; Ayako Hirai; Kazue Yoneda; Fumihiro Tanaka; Yoshiko Iwai
Immunology letters, Apr. 2018, Reviewed

Measles virus induces persistent infection by autoregulation of viral replication.
Tomomitsu Doi; Hyun-Jeong Kwon; Tomoyuki Honda; Hiroki Sato; Misako Yoneda; Chieko Kai
Scientific reports, Nov. 2016, Reviewed
Lead

IgA plasma cells express the negative regulatory co-stimulatory molecule programmed cell death 1 ligand and have a potential tolerogenic role in the intestine.
Tomomitsu Doi; Takanori Kanai; Yohei Mikami; Tomohisa Sujino; Li Jun; Yuichi Ono; Atsushi Hayashi; Toshifumi Hibi
Biochemical and biophysical research communications, Sep. 2012, Reviewed
Lead

CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis.
Takahiro Mizukami; Takanori Kanai; Yohei Mikami; Atsushi Hayashi; Tomomitsu Doi; Tango Handa; Atsuhiro Matsumoto; Li Jun; Katsuyoshi Matsuoka; Toshiro Sato; Tadakazu Hisamatsu; Toshifumi Hibi
Immunology letters, Sep. 2012, Reviewed

Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
Lucia Kato; Nasim A. Begum; A. Maxwell Burroughs; Tomomitsu Doi; Jun Kawai; Carsten O. Daub; Takahisa Kawaguchi; Fumihiko Matsuda; Yoshihide Hayashizaki; Tasuku Honjo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2012, Reviewed, No invitation

Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells.
Tomohisa Sujino; Takanori Kanai; Yuichi Ono; Yohei Mikami; Atsushi Hayashi; Tomomitsu Doi; Katsuyoshi Matsuoka; Tadakazu Hisamatsu; Hiromasa Takaishi; Haruhiko Ogata; Akihiko Yoshimura; Dan R Littman; Toshifumi Hibi
Gastroenterology, Sep. 2011, Reviewed

AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
Maki Kobayashi; Masatoshi Aida; Hitoshi Nagaoka; Nasim A. Begum; Yoko Kitawaki; Mikiyo Nakata; Andre Stanlie; Tomomitsu Doi; Lucia Kato; Il-mi Okazaki; Reiko Shinkura; Masamichi Muramatsu; Kazuo Kinoshita; Tasuku Honjo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2009, Reviewed, No invitation

Molecular mechanism for generation of antibody memory
Velizar Shivarov; Reiko Shinkura; Tomomitsu Doi; Nasim A. Begum; Hitoshi Nagaoka; Il-Mi Okazaki; Satomi Ito; Taichiro Nonaka; Kazuo Kinoshita; Tasuku Honjo
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Mar. 2009, Reviewed, No invitation

The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavaqe in class switch recombination
Tomomitsu Doi; Lucia Kato; Satomi Ito; Reiko Shinkura; Min Wei; Hitoshi Nagaoka; Jishu Wang; Tasuku Honjo
Proceedings of the National Academy of Sciences of the United States of America, Feb. 2009, Reviewed, No invitation

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination
Nasim A. Begum; Andre Stanlie; Tomomitsu Doi; Yoko Sasaki; Hai Wei Jin; Yong Sung Kim; Hitoshi Nagaoka; Tasuku Honjo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2009, Reviewed, No invitation

Carboxy-terminal domain of AID required for its mRNA complex formation in vivo.
Nonaka T; Doi T; Toyoshima T; Muramatsu M; Honjo T; Kinoshita K
Proceedings of the National Academy of Sciences of the United States of America, Feb. 2009, Reviewed, No invitation

PI3K is a negative regulator of IgE production
Tomomitsu Doi; Kunie Obayashi; Takashi Kadowaki; Hideki Fujii; Shigeo Koyasu
INTERNATIONAL IMMUNOLOGY, Apr. 2008, Reviewed, No invitation

The p85α Regulatory Subunit of Class IA Phosphoinositide 3-Kinase Regulates β-Selection in Thymocyte Development
Fumiko Shiroki; Satoshi Matsuda; Tomomitsu Doi; Mari Fujiwara; Yoshito Mochizuki; Takashi Kadowaki; Harumi Suzuki; Shigeo Koyasu
The Journal of Immunology, Feb. 2007, Reviewed

Dendritic cells suppress IgE production in B cells
Kunie Obayashi; Tomomitsu Doi; Shigeo Koyasu
INTERNATIONAL IMMUNOLOGY, Feb. 2007, Reviewed, No invitation

De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
Tomomitsu Doi; Kazuo Kinoshita; Masaya Ikegawa; Masamichi Muramatsu; Tasuku Honjo
Proceedings of the National Academy of Sciences, Mar. 2003, Reviewed

肺癌の進展における炎症性カスパーゼの機能解明
千葉 要祐, 遠藤 元誉, 土井 知光, 大林 邦衣, 矢寺 和博
日本呼吸器学会誌, Mar. 2023, Null, Null

肺癌の進展における炎症性カスパーゼの機能解明
千葉 要祐, 遠藤 元誉, 土井 知光, 大林 邦衣, 矢寺 和博
日本呼吸器学会誌, Mar. 2023, Null, Null

呼吸器疾患における炎症性カスパーゼ・パイロトーシスの機能解明
千葉 要祐, 遠藤 元誉, 土井 知光, 大林 邦枝, 矢寺 和博
日本呼吸器学会誌, Apr. 2022, Null, Null

呼吸器疾患における炎症性カスパーゼ・パイロトーシスの機能解明
千葉 要祐, 遠藤 元誉, 土井 知光, 大林 邦枝, 矢寺 和博
日本呼吸器学会誌, Apr. 2022, Null, Null

Caspase4はROCK-cofilin経路を介して肝癌細胞の多倍体化を調整する
隅田 和広, 土井 知光, 大林 邦衣, 松川 卓生, 千葉 要佑, 長坂 昌平, 小山 倫太郎, 遠藤 元誉
日本抗加齢医学会総会プログラム・抄録集, May 2024, Null, Null

Caspase4はROCK-cofilin経路を介して肝癌細胞の多倍体化を調整する
隅田 和広, 土井 知光, 大林 邦衣, 松川 卓生, 千葉 要佑, 長坂 昌平, 小山 倫太郎, 遠藤 元誉
日本抗加齢医学会総会プログラム・抄録集, May 2024, Null, Null

組織幹細胞に自己複製と分化を誘導するWNT/βカテニンシグナルの標的遺伝子は転写因子c-JUNによって調節されている
土井 知光, 大林 邦衣, 遠藤 元誉
日本抗加齢医学会総会プログラム・抄録集, May 2024, Null, Null

組織幹細胞に自己複製と分化を誘導するWNT/βカテニンシグナルの標的遺伝子は転写因子c-JUNによって調節されている
土井 知光, 大林 邦衣, 遠藤 元誉
日本抗加齢医学会総会プログラム・抄録集, May 2024, Null, Null

非小細胞肺癌の進展における炎症性カスパーゼの機能解明
千葉 要祐, 土井 知光, 大林 邦衣, 松川 卓生, 隅田 和広, 加藤 香織, 遠藤 元誉, 矢寺 和博
産業医科大学雑誌, Mar. 2023, Null, Null

非小細胞肺癌の進展における炎症性カスパーゼの機能解明
千葉 要祐, 土井 知光, 大林 邦衣, 松川 卓生, 隅田 和広, 加藤 香織, 遠藤 元誉, 矢寺 和博
産業医科大学雑誌, Mar. 2023, Null, Null

PD-1結合能を指標とした血中PD-L1測定法の開発
竹内 雅大, 土井 知光, 大林 邦衣, 米田 和恵, 田中 文啓, 岩井 佳子
肺癌, Sep. 2017, Null, Null

PD-1結合能を指標とした血中PD-L1測定法の開発
竹内 雅大, 土井 知光, 大林 邦衣, 米田 和恵, 田中 文啓, 岩井 佳子
肺癌, Sep. 2017, Null, Null

Caspase-4 has a role in cell division in epithelial cells through actin depolymerization.
Sumida K, Doi T, Obayashi K, Chiba Y, Nagasaka S, Ogino N, Miyagawa K, Baba R, Morimoto H, Hara H, Terabayashi T, Ishizaki T, Harada M, Endo M
Biochemical and Biophysical Research Communications, Feb. 2024, Reviewed, Null

Angiopoietin-like protein 2 decreases peritoneal metastasis of ovarian cancer cells by suppressing anoikis resistance.
Takeshita Y, Motohara T, Kadomatsu T, Doi T, Obayashi K, Oike Y, Katabuchi H, Endo M
Biochemical and Biophysical Research Communications, Jun. 2021, Reviewed, No invitation

ANGPTL8 links inflammation and poor differentiation, which are characteristics of malignant renal cell carcinoma.
Matsukawa Takuo, Doi Tomomitsu, Obayashi Kunie, Sumida Kazuhiro, Fujimoto Naohiro, Endo Motoyoshi
Cancer science, Apr. 2023, Reviewed, No invitation

Caspase-4 promotes metastasis and interferon-γ-induced pyroptosis in lung adenocarcinoma.
Chiba Yosuke, Doi Tomomitsu, Obayashi Kunie, Sumida Kazuhiro, Nagasaka Shohei, Wang Ke-Yong, Yamasaki Kei, Masago Katsuhiro, Matsushita Hirokazu, Kuroda Hiroaki, Yatera Kazuhiro, Endo Motoyoshi
Communications biology, Jun. 2024, Reviewed, No invitation

Involvement of activator protein-1 family members in -catenin and p300 association on the genome of PANC-1 cells
Tomomitsu Doi, Hironori Hojo, Shinsuke Ohba, Kunie Obayashi, Motoyoshi Endo, Toshimasa Ishizaki, Akira Katoh, and Hiroyuki Kouji
Heliyon, Feb. 2022, Reviewed, No invitation
Lead

Soluble PD-L1 with PD-1-binding capacity exists in the plasma of patients with non-small cell lung cancer.
Takeuchi Masahiro, Doi Tomomitsu, Obayashi Kunie, Hirai Ayako, Yoneda Kazue, Tanaka Fumihiro, Iwai Yoshiko
Immunology letters, Apr. 2018, Reviewed, No invitation

Measles virus induces persistent infection by autoregulation of viral replication.
Doi Tomomitsu, Kwon Hyun-Jeong, Honda Tomoyuki, Sato Hiroki, Yoneda Misako, Kai Chieko
Scientific reports, Nov. 2016, Reviewed, No invitation
Lead

Caspase4はcofilin活性を介して肝癌細胞の多倍体化を制御する(Caspase4 regulates polyploidization of hepatocellular carcinoma cells through cofilin activity)
隅田 和広, 土井 知光, 大林 邦衣, 松川 卓生, 千葉 要祐, 長坂 昌平, 小山 倫太郎, 遠藤 元誉
日本癌学会総会記事, Sep. 2023, Null, Null

Caspase4はcofilin活性を介して肝癌細胞の多倍体化を制御する(Caspase4 regulates polyploidization of hepatocellular carcinoma cells through cofilin activity)
隅田 和広, 土井 知光, 大林 邦衣, 松川 卓生, 千葉 要祐, 長坂 昌平, 小山 倫太郎, 遠藤 元誉
日本癌学会総会記事, Sep. 2023, Null, Null

Caspase-4 has a role in cell division in epithelial cells through actin depolymerization.
Sumida Kazuhiro, Doi Tomomitsu, Obayashi Kunie, Chiba Yosuke, Nagasaka Shohei, Ogino Noriyoshi, Miyagawa Koichiro, Baba Ryoko, Morimoto Hiroyuki, Hara Hideki, Terabayashi Takeshi, Ishizaki Toshimasa, Harada Masaru, Endo Motoyoshi
Biochemical and biophysical research communications, Feb. 2024, Null, Null

Angiopoietin-like protein 2 decreases peritoneal metastasis of ovarian cancer cells by suppressing anoikis resistance.
Takeshita Yuko, Motohara Takeshi, Kadomatsu Tsuyoshi, Doi Tomomitsu, Obayashi Kunie, Oike Yuichi, Katabuchi Hidetaka, Endo Motoyoshi
Biochemical and biophysical research communications, Jul. 2021, Null, Null

ANGPTL8 links inflammation and poor differentiation, which are characteristics of malignant renal cell carcinoma.
Matsukawa Takuo, Doi Tomomitsu, Obayashi Kunie, Sumida Kazuhiro, Fujimoto Naohiro, Endo Motoyoshi
Cancer science, Apr. 2023, Null, Null

Involvement of activator protein-1 family members in β-catenin and p300 association on the genome of PANC-1 cells.
Doi Tomomitsu, Hojo Hironori, Ohba Shinsuke, Obayashi Kunie, Endo Motoyoshi, Ishizaki Toshimasa, Katoh Akira, Kouji Hiroyuki
Heliyon, Feb. 2022, Null, Null

Soluble PD-L1 with PD-1-binding capacity exists in the plasma of patients with non-small cell lung cancer.
Takeuchi Masahiro, Doi Tomomitsu, Obayashi Kunie, Hirai Ayako, Yoneda Kazue, Tanaka Fumihiro, Iwai Yoshiko
Immunology letters, Apr. 2018, Reviewed, No invitation