Mar. 2026
The Japanese Pharmacological Society, Excellent Presentation Award
Celecoxib derivative OSU-03012 ameliorated pulmonary fibrosis through modulation of ECM remodeling
Kohei Hashimoto;Masaki Arioka;Msahiro Tahara;Kazuhiro Yatera;Fumi Takahashi

Oct. 2025
産業医科大学学会, 最優秀ポスター賞
高温多湿環境下における労働者の認知機能および生理学的応答に及ぼすカフェイン摂取の影響
有岡 将基;伊藤 一馬;橋本 康平;高橋 富美

Mar. 2025
The Japanese Pharmacological Society, Graduate Student Presentation Award
2,5-Dimethylcelecoxib attenuates pulmonary fibrosis by suppressing the fibroblast-myofibroblast transformation
Toshiki Morimoto;Shin Isikane;Kohei Hashimoto;Masaki Arioka;Masahiro Tahara;Kei Yamasaki;Kazuhiro Yatera;Fumi Takahashi

Sep. 2019
European Society For Medical Oncology, ESMO Congress Merit Award
Anti-cancer effects of differentiation-inducing factor-1 in triple negative breast cancer
Fumi Tetsuo;Masaki Arioka;Toshiyuki Sasaguri

Jun. 2019
American Association Dental Research, AADR Hatton Award Finalist
Masaki Arioka
97th International Association Dental Research/48th American Association Dental Researchの歯科学会として世界最大の国際学会において、Hatton Awardのコンペティションの200人の応募者から9人のファイナリストとして選出された。

Nov. 2015
48th Annual Meeting of the American Society of Nephrology, Top Oral Abstracts for ASN
Narihito Tatumoto;Masaki Arioka
48th Annual Meeting of the American Society of Nephrologyで発表したリチウムが腎臓障害性の骨粗鬆そうの改善に働く内容が高く評価され、Top Oral Abstracts for ASNに選出された。

Jun. 2014
Japan Student Services Organization, Full Exemption of Japan Student Services Organization (JASSO) Graduate School Type 1 Scholarship (Repayment Exemption based on Particularly Outstanding Achievements)
Masaki Arioka
日本学生支援機構大学院第一種奨学金全額免除(特に優れた業績による返還免除)

Mar. 2014
Kyushu University, Kyushu University Student Award for Academic Research Activities
Masaki Arioka

Mar. 2014
Graduate School of Dental Science, Kyushu University, Hiroshi Fujino Award
Masaki Arioka
2014年度に九州大学大学院歯学府を卒業した大学院生で最も優秀と判断されたため、藤野博賞を受賞した。

Oct. 2013
Japanese Society of Oral and Maxillofacial Surgeons, Gold Ribbon Award
Masaki Arioka
第58回日本口腔外科学会総会・学術大会でポスター発表したリチウムの骨再生作用についての内容が高く評価され、ゴールドリボン賞を受賞した。

Sep. 2013
Japanese Society of Oral Implantology, Excellent Research Presentation Award
Masaki Arioka
第43回日本口腔インプラント学会学術大会で発表したリチウムの骨再生作用についての内容が高く評価され、優秀研究発表賞を受賞した。

Nov. 2012
The Japanese Pharmacological Society, Excellent Presentation Award
Masaki Arioka
第65回日本薬理学会西南部会で発表したリチウムの骨再生作用の研究が高く評価され、優秀発表賞を受賞した。

Sep. 2012
九州大学歯学府, Excellent Presentation Award
Masaki Arioka
2012年度に九州大学大学院歯学府で行われた中間発表会で優秀と判断されたため、優秀発表賞を受賞した。

2,5-Dimethylcelecoxib inhibits lung fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis
Toshiki Morimoto; Shin Ishikane; Masaki Arioka; Kohei Hashimoto; Kazunobu Igawa; Yasuyuki Higashi; Taisuke Tomonaga; Chinatsu Nishida; Kazuhiro Yatera; Fumi Takahashi-Yanaga
Respiratory Investigation, May 2026, Reviewed, No invitation

Postoperative administration of 2,5-dimethylcelecoxib attenuates ischemia-reperfusion injury-induced cardiac dysfunction
Shin Ishikane; Takehiro Kishigami; Eigo Ikushima; Masaki Arioka; Kazunobu Igawa; Fumi Takahashi-Yanaga
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2026, Reviewed, No invitation

Celecoxib inhibits skin fibrosis via suppressing adipocyte progenitor–myofibroblast transdifferentiation by attenuating the YAP/TAZ signaling pathway
Masaki Arioka; Hiroaki Matsunaga; Shin Ishikane; Kazuma Ito; Kohei Hashimoto; Yi Wang; Kazunobu Igawa; Fumi Takahashi-Yanaga
Life Sciences, Oct. 2025, Reviewed, No invitation
Lead, Corresponding

Multiscale, interspecies evaluation of parameters affecting alveolar bone repair
Pavla Ticha; Arush Joshi; Julia S. Dworan; Marzia Armaro; Masaki Arioka; Quanchen Xu; Igor Pilawski; Yindong Liu; Chih‐Hao Chen; Xibo Pei; Ustun Serdar Tulu; Hannes Traxler; Yasemin Erdogan; Jill A. Helms
Journal of Periodontology, Jul. 2025, Reviewed, No invitation

Differentiation-inducing factor-1 inhibits EMT by proteasomal degradation of TAZ and YAP in cervical and colon cancer cell lines.
Masaki Arioka; Wang Yi; Kazunobu Igawa; Shin Ishikane; Fumi Takahashi-Yanaga
European journal of pharmacology, Dec. 2024, Reviewed, No invitation
Lead

Mammalian target of differentiation-inducing factor-1 is mitochondrial malate dehydrogenase for activation of AMP-activated protein kinase and induction of mitochondrial fission
Masaki Arioka; Koichi Miura; Ruzhe Han; Kazunobu Igawa; Fumi Takahashi-Yanaga; Toshiyuki Sasaguri
Life Sciences, Aug. 2024, Reviewed, No invitation
Lead, Corresponding

Predentin's influence on clastic cell behavior in human external cervical resorption: Evidence from a case study
Toshihiro Noma; Shohei Yoshimoto; Yasuhiko Kamura; Masaki Arioka
Journal of Dental Sciences, Jul. 2024, Reviewed, No invitation
Last, Corresponding

2,5-Dimethyl-celecoxib induces early termination of inflammatory responses by transient macrophage accumulation and inhibits the progression of cardiac remodeling in a mouse model of cryoinjury-induced myocardial infarction
Takehiro Kishigami; Shin Ishikane; Masaki Arioka; Kazunobu Igawa; Yosuke Nishimura; Fumi Takahashi-Yanaga
Journal of Pharmacological Sciences, Feb. 2024, Reviewed, No invitation

Differentiation-inducing factor-1 reduces lipopolysaccharide-induced vascular cell adhesion molecule-1 by suppressing mTORC1-S6K signaling in vascular endothelial cells.
Masaki Arioka; Fumi Seto-Tetsuo; Takeru Inoue; Koichi Miura; Shin Ishikane; Kazunobu Igawa; Katsuhiko Tomooka; Fumi Takahashi-Yanaga; Toshiyuki Sasaguri
Life sciences, Nov. 2023, Reviewed, No invitation
Lead, Corresponding

Promising small molecule anti-fibrotic agents: Newly developed or repositioned drugs targeting myofibroblast transdifferentiation.
Ishikane S; Arioka M; Takahashi-Yanaga F
Biochemical pharmacology, Jun. 2023, Reviewed, Invited
Lead

Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission
Takeru Inoue; Koichi Miura; Ruzhe Han; Fumi Seto-Tetsuo; Masaki Arioka; Kazunobu Igawa; Katsuhiko Tomooka; Toshiyuki Sasaguri
Journal of Pharmacological Sciences, May 2023, Reviewed, No invitation

DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells
Fumi Seto-Tetsuo; Masaki Arioka; Koichi Miura; Takeru Inoue; Kazunobu Igawa; Katsuhiko Tomooka; Toshiyuki Sasaguri
International Immunopharmacology, Apr. 2023, Reviewed
Corresponding

Increased risk of metastasis in patients with incidental use of renin-angiotensin system inhibitors: a retrospective analysis for multiple types of cancer based on electronic medical records
Akie Hirata; Shin Ishikane; Fumi Takahashi-Yanaga; Masaki Arioka; Tasuku Okui; Chinatsu Nojiri; Toshiyuki Sasaguri; Naoki Nakashima
Hypertension Research, Sep. 2022, Reviewed

A WNT protein therapeutic accelerates consolidation of a bone graft substitute in a pre‐clinical sinus augmentation model
Benjamin R. Coyac; Benjamin J. Wolf; Daniel J. Bahat; Masaki Arioka; John B. Brunski; Jill A. Helms
Journal of Clinical Periodontology, Jun. 2022, Reviewed, No invitation

Angiotensin II promotes primary tumor growth and metastasis formation of murine TNBC 4T1 cells through the fibroblasts around cancer cells.
Takiguchi T; Takahashi-Yanaga F; Ishikane S; Fumi Tetsuo; Hosoda H; Arioka M; Kitazono T; Sasaguri T
European journal of pharmacology, Aug. 2021, Reviewed, No invitation

DIF-1 inhibits growth and metastasis of triple-negative breast cancer through AMPK-mediated inhibition of the mTORC1-S6K signaling pathway.
Fumi Tetsuo; Masaki Arioka; Miura K; Inoue T; Igawa K; Tomooka K; Takahashi-Yanaga F; Toshiyuki Sasaguri
Oncogene, Jul. 2021, Reviewed, No invitation
Corresponding

Accelerating Socket Repair via WNT3A Curtails Alveolar Ridge Resorption.
Masaki Arioka; Dawid IM; Cuevas PL; Benjamin R. Coyac; Given Names Deactivated Family Name Deactivated; Leahy B; Wang L; Xue Yuan; Li Z; Zhang X; Liu B; Jill Helms
Journal of dental research, Jun. 2021, Reviewed, No invitation
Lead

Cardiac and renal protective effects of 2,5-dimethylcelecoxib in angiotensin II and high-salt-induced hypertension model mice
Misaki Yamamoto; Fumi Takahashi-Yanaga; Masaki Arioka; Kazunobu Igawa; Katsuhiko Tomooka; Ken Yamaura; Toshiyuki Sasaguri
Journal of Hypertension, Nov. 2020, Reviewed, No invitation

Pro-osteogenic Effects of WNT in a Mouse Model of Bone Formation Around Femoral Implants.
Li Z; Xue Yuan; Arioka M; Bahat D; Sun Q; Chen J; Jill Helms
Calcified tissue international, Sep. 2020, Reviewed, No invitation

Interspecies Comparison of Alveolar Bone Biology, Part I: Morphology and Physiology of Pristine Bone
I. Pilawski; U.S. Tulu; P. Ticha; P. Schüpbach; H. Traxler; Q. Xu; J. Pan; B.R. Coyac; X. Yuan; Y. Tian; Y. Liu; J. Chen; Y. Erdogan; M. Arioka; M. Armaro; M. Wu; J.B. Brunski; J.A. Helms
JDR Clinical & Translational Research, Jul. 2020, Reviewed, No invitation

Interspecies comparison of alveolar bone biology: Tooth extraction socket healing in mini pigs and mice.
Pan J; Pilawski I; Xue Yuan; Arioka M; Ticha P; Tian Y; Jill Helms
Journal of periodontology, Jun. 2020, Reviewed, No invitation

Masqueraders of angioedema after a dental procedure.
Ivan Lee; Arioka M; Sara Kleinman; Gernez Y
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, Mar. 2020, Reviewed, No invitation
Lead

Effects of condensation and compressive strain on implant primary stability: A longitudinal, in vivo, multiscale study in mice.
Li Z; Arioka M; Liu Y; Aghvami M; Tulu S; Brunski JB; Jill Helms
Bone & joint research, Feb. 2020, Reviewed, No invitation

Differentiation-inducing factor-1 suppresses cyclin D1-induced cell proliferation of MCF-7 breast cancer cells by inhibiting S6K-mediated signal transducer and activator of transcription 3 synthesis
Fumi Tetsuo; Masaki Arioka; Koichi Miura; Misato Kai; Momoko Kubo; Kazunobu Igawa; Katsuhiko Tomooka; Fumi Takahashi-Yanaga; Fusanori Nishimura; Toshiyuki Sasaguri
Cancer Science, Dec. 2019, Reviewed, No invitation
Corresponding

2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation
Shoji Morishige; Fumi Takahashi-Yanaga; Shin Ishikane; Masaki Arioka; Kazunobu Igawa; Akihiro Kuroo; Katsuhiko Tomooka; Akira Shiose; Toshiyuki Sasaguri
Biochemical Pharmacology, Oct. 2019, Reviewed, No invitation

WNT3A accelerates delayed alveolar bone repair in ovariectomized mice.
Liu Y; Li Z; Arioka M; Wang L; Bao C; Jill Helms
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, Jul. 2019, Reviewed, No invitation
Lead

Glycogen synthase kinase-3 inhibitor as a multi-targeting anti-rheumatoid drug
Masaki Arioka; Fumi Takahashi-Yanaga
Biochemical Pharmacology, Jul. 2019, Reviewed, Invited
Lead

Influence of genetic polymorphisms and habitual caffeine intake on the changes in blood pressure, pulse rate, and calculation speed after caffeine intake A prospective, double blind, randomized trial in healthy volunteers
Tatsuya Yoshihara; Masayoshi Zaitsu; Fumie Shiraishi; Hisatomi Arima; Fumi Takahashi-Yanaga; masaki arioka; Shunichi Kajioka; Toshiyuki Sasaguri
Journal of Pharmacological Sciences, Mar. 2019, Reviewed, No invitation

A Novel Osteotomy Preparation Technique to Preserve Implant Site Viability and Enhance Osteogenesis.
Chih-Hao Chen; Benjamin R. Coyac; Arioka M; Leahy B; Tulu US; Aghvami M; Holst S; Waldemar Hoffmann; Quarry A; Bahat O; Benjamin SALMON; Brunski JB; Jill Helms
Journal of clinical medicine, Feb. 2019, Reviewed, No invitation
Lead

Osteoporotic Changes in the Periodontium Impair Alveolar Bone Healing
M. Arioka; X. Zhang; Z. Li; U.S. Tulu; Y. Liu; L. Wang; X. Yuan; J.A. Helms
Journal of Dental Research, Jan. 2019, Reviewed, No invitation
Lead

Molecular Basis for Periodontal Ligament Adaptation to In Vivo Loading
X. Zhang; X. Yuan; Q. Xu; M. Arioka; L.A. Van Brunt; Y. Shi; J. Brunski; J.A. Helms
Journal of Dental Research, Jan. 2019, Reviewed, No invitation

An osteopenic/osteoporotic phenotype delays alveolar bone repair
Chih-Hao Chen; Liao Wang; U. Serdar Tulu; Masaki Arioka; Melika Maghazeh Moghim; Benjamin Salmon; Chien-Tzung Chen; Waldemar Hoffmann; Jessica Gilgenbach; John B. Brunski; Jill A. Helms
Bone, Jul. 2018, Reviewed, No invitation

A Comparative Assessment of Implant Site Viability in Humans and Rats
C.-H. Chen; X. Pei; U.S. Tulu; M. Aghvami; C.-T. Chen; D. Gaudillière; M. Arioka; M. Maghazeh Moghim; O. Bahat; M. Kolinski; T.R. Crosby; A. Felderhoff; J.B. Brunski; J.A. Helms
Journal of Dental Research, Dec. 2017, Reviewed, No invitation

Inorganic phosphate-induced impairment of osteoclast cell-cell fusion by the inhibition of AP-1-mediated DC-STAMP expression
Masaki Arioka; Fumi Takahashi-Yanaga; Narihito Tatsumoto; Toshiyuki Sasaguri
Biochemical and Biophysical Research Communications, Nov. 2017, Reviewed, No invitation
Lead, Corresponding

Anti-tumor effects of differentiation-inducing factor-1 in malignant melanoma: GSK-3-mediated inhibition of cell proliferation and GSK-3-independent suppression of cell migration and invasion.
Arioka M; Takahashi-Yanaga F; Kubo M; Igawa K; Tomooka K; Sasaguri T
Biochemical pharmacology, May 2017, Reviewed, No invitation
Lead

A case of pediatric mandibular osteonecrosis caused by leakage of arsenic trioxide
Masaki ARIOKA; Masanori SASAKI; Kotaro ISHII; Masaki KANAMOTO; Takahiro YAMASHIRO; Yoshihide MORI
Japanese Journal of Oral and Maxillofacial Surgery, Jan. 2017, Reviewed, No invitation
Lead, Corresponding

Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes.
Nagano A; Arioka M; Takahashi-Yanaga F; Matsuzaki E; Sasaguri T
Journal of pharmacological sciences, Dec. 2016, Reviewed, No invitation
Lead

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway.
Egashira I; Takahashi-Yanaga F; Nishida R; Arioka M; Igawa K; Tomooka K; Nakatsu Y; Tsuzuki T; Yusaku Nakabeppu; Kitazono T; Sasaguri T
Cancer science, Dec. 2016, Reviewed, No invitation

Inhibition of GSK-3β increases trabecular bone volume but not cortical bone volume in adenine-induced uremic mice with severe hyperparathyroidism.
Tatsumoto N; Arioka M; Yamada S; Takahashi-Yanaga F; Tokumoto M; Tsuruya K; Kitazono T; Sasaguri T
Physiological reports, Nov. 2016, Reviewed, No invitation
Corresponding

2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation.
Fujita A; Takahashi-Yanaga F; Sachio Morimoto; Yoshihara T; Arioka M; Igawa K; Tomooka K; Hoka S; Sasaguri T
Hypertension research : official journal of the Japanese Society of Hypertension, Sep. 2016, Reviewed, No invitation

Inhibition of GSK-3 reduces prostaglandin E2 production by decreasing the expression levels of COX-2 and mPGES-1 in monocyte/macrophage lineage cells.
Noma T; Takahashi-Yanaga F; Arioka M; Mori Y; Sasaguri T
Biochemical pharmacology, Jul. 2016, Reviewed, No invitation

GSK-3β heterozygous knockout is cardioprotective in a knockin mouse model of familial dilated cardiomyopathy.
Rasha Mohamed; Sachio Morimoto; Islam Ahmed Abd El-Hamed Ibrahim; Zhan DY; Du CK; Arioka M; Yoshihara T; Takahashi-Yanaga F; Sasaguri T
American journal of physiology. Heart and circulatory physiology, Apr. 2016, Reviewed, No invitation

Stage-dependent benefits and risks of pimobendan in mice with genetic dilated cardiomyopathy and progressive heart failure
Nonaka Miki; Sachio Morimoto; Murayama Takashi; Kurebayashi Nagomi; Li Lei; Wang Yuan-Yuan; Masaki Arioka; Yoshihara Tatsuya; Fumi Takahashi; Toshiyuki Sasaguri
BRITISH JOURNAL OF PHARMACOLOGY, May 2015, Reviewed, No invitation

Hyperbaric Oxygen Stimulates the Proliferation and Differentiation of Raw264.7 Cells
Tomotaka Sugi; Masanori Sasaki; Takahiro Yamashiro; Takaoki Tsuneyoshi; Arioka Masaki; Akihiko Matsumoto; Kumamaru Wataru; Nakano Hiroyuki; Mori Yoshihide
Open Journal of Stomatology, May 2015, Reviewed, No invitation

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.
Kubokura N; Takahashi-Yanaga F; Arioka M; Yoshihara T; Igawa K; Tomooka K; Sachio Morimoto; Nakatsu Y; Tsuzuki T; Yusaku Nakabeppu; Matsumoto T; Kitazono T; Sasaguri T
Journal of pharmacological sciences, Mar. 2015, Reviewed, No invitation

Acceleration of bone regeneration by local application of lithium: Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis (vol 90, pg 397, 2014)
Masaki Arioka; Fumi Takahashi-Yanaga; Masanori Sasaki; Tatsuya Yoshihara; Sachio Morimoto; Masato Hirata; Yoshihide Mori; Toshiyuki Sasaguri
BIOCHEMICAL PHARMACOLOGY, Oct. 2014, Reviewed, No invitation
Lead

Acceleration of bone regeneration by local application of lithium: Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis.
Arioka M; Takahashi-Yanaga F; Sasaki M; Yoshihara T; Sachio Morimoto; Hirata M; Mori Y; Sasaguri T
Biochemical pharmacology, Jun. 2014, Reviewed, No invitation
Lead

Acceleration of bone development and regeneration through the Wnt/β-catenin signaling pathway in mice heterozygously deficient for GSK-3β.
Arioka M; Takahashi-Yanaga F; Sasaki M; Yoshihara T; Sachio Morimoto; Takashima A; Mori Y; Sasaguri T
Biochemical and biophysical research communications, Oct. 2013, Reviewed, No invitation
Lead

ベッドサイドの薬理学
笹栗 俊之; 宮田 篤郎 編著, Joint work
丸善出版, May 2018