Delayed inactivation of TRPC6 as a determinative characteristic of FSGS-associated variants
Ryo Okada; Reiko Sakaguchi; Tatsuya Komaki; Ryu Nonaka; Onur K. Polat; Takanori Kihara; Katsuhiko Asanuma; Takeshi Yamamoto; Yoshitaka Isaka; Yasuo Mori; Masayuki X. Mori
Journal of Biological Chemistry, Jun. 2025, Reviewed, No invitation

Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation
Masayuki X. Mori; Ryo Okada; Reiko Sakaguchi; Hideharu Hase; Yuko Imai; Onur K. Polat; Satoru G. Itoh; Hisashi Okumura; Yasuo Mori; Yasushi Okamura; Ryuji Inoue
Scientific Reports, Dec. 2022

Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade
Ryo Okada; Xinwen Zhang; Yuka Harada; Zhou Wu; Hiroshi Nakanishi
Inflammation Research, May 2018, Reviewed, No invitation

Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier
Ryo Okada; Zhou Wu; Aiqin Zhu; Junjun Ni; Jingqi Zhang; Yoshito Yoshimine; Christoph Peters; Paul Saftig; Hiroshi Nakanishi
MOLECULAR AND CELLULAR NEUROSCIENCE, Jan. 2015, Reviewed, No invitation

Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State
Xinwen Zhang; Zhou Wu; Yoshinori Hayashi; Ryo Okada; Hiroshi Nakanishi
JOURNAL OF NEUROSCIENCE, Feb. 2014, Reviewed, No invitation

Differential pathways for interleukin-1 beta production activated by chromogranin A and amyloid beta in microglia
Zhou Wu; Li Sun; Sadayuki Hashioka; Sheng Yu; Claudia Schwab; Ryo Okada; Yoshinori Hayashi; Patrick L. McGeer; Hiroshi Nakanishi
NEUROBIOLOGY OF AGING, Dec. 2013, Reviewed, No invitation

Possible involvement of aiPLA(2) in the phosphatidylserine-containing liposomes induced production of PGE(2) and PGD(2) in microglia
Fumiko Takayama; Zhou Wu; Hong Mei Ma; Ryo Okada; Yoshinori Hayashi; Hiroshi Nakanishi
JOURNAL OF NEUROIMMUNOLOGY, Sep. 2013, Reviewed, No invitation

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S
Yoshinori Hayashi; Satoru Koyanagi; Naoki Kusunose; Ryo Okada; Zhou Wu; Hidetoshi Tozaki-Saitoh; Kiyoharu Ukai; Shinichi Kohsaka; Kazuhide Inoue; Shigehiro Ohdo; Hiroshi Nakanishi
SCIENTIFIC REPORTS, Sep. 2013, Reviewed, No invitation

Phosphatidylserine recognition and induction of apoptotic cell clearance by Drosophila engulfment receptor Draper
Tran Thanh Tung; Kaz Nagaosa; Yu Fujita; Asana Kita; Hiroki Mori; Ryo Okada; Saori Nonaka; Yoshinobu Nakanishi
JOURNAL OF BIOCHEMISTRY, May 2013, Reviewed, No invitation

Brazilian Green Propolis Suppresses the Hypoxia-Induced Neuroinflammatory Responses by Inhibiting NF-kappa B Activation in Microglia
Zhou Wu; Aiqin Zhu; Fumiko Takayama; Ryo Okada; Yicong Liu; Yuka Harada; Shizheng Wu; Hiroshi Nakanishi
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2013, Reviewed, No invitation

Diurnal Spatial Rearrangement of Microglial Processes through the Rhythmic Expression of P2Y12 Receptors.
Hayashi Y; Koyanagi S; Kusunose N; Takayama F; Okada R; Wu Z; Ohdo S; Nakanishi H
Journal of Neurological Disorders, 2013, Reviewed, No invitation

Apoptosis-dependent Externalization and Involvement in Apoptotic Cell Clearance of DmCaBP1, an Endoplasmic Reticulum Protein of Drosophila
Ryo Okada; Kaz Nagaosa; Takayuki Kuraishi; Hiroshi Nakayama; Naoko Yamamoto; Yukiko Nakagawa; Naoshi Dohmae; Akiko Shiratsuchi; Yoshinobu Nakanishi
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2012, Reviewed, No invitation

Integrin beta nu-mediated Phagocytosis of Apoptotic Cells in Drosophila Embryos
Kaz Nagaosa; Ryo Okada; Saori Nonaka; Kazuki Takeuchi; Yu Fujita; Tomoyuki Miyasaka; Junko Manaka; Istvan Ando; Yoshinobu Nakanishi
JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2011, Reviewed, No invitation

蛋白尿改善を目指したイオンチャネル阻害剤の開発と評価
坂口怜子, 松田由宗, 岡田亮, 石兼真, 高橋富美, 片渕瑛介, 中山敏幸, 眞田賢哉 上田陽一, 木原隆典, 永田龍, 森誠之
Journal of UOEH, Mar. 2024, Reviewed, Null

生化学・分子生物学　腎変性"FSGS"の発症を抑制するTRPC6のカルシウム依存的不活性化機構(CDI)
森 誠之, 岡田 亮
医学のあゆみ, Jul. 2020, Not reviewed, Invited

生化学・分子生物学　腎変性"FSGS"の発症を抑制するTRPC6のカルシウム依存的不活性化機構(CDI)
森 誠之, 岡田 亮
医学のあゆみ, Jul. 2020, Null, Null

腎疾患に繋がるTRPC6変異体における不活性化機構の破綻と発症年齢の連関
小牧 竜也, 岡田 亮, 木原 隆典, 森 誠之
日本生化学会大会プログラム・講演要旨集, Nov. 2021, Null, Null

腎疾患に繋がるTRPC6変異体における不活性化機構の破綻と発症年齢の連関
小牧 竜也, 岡田 亮, 木原 隆典, 森 誠之
日本生化学会大会プログラム・講演要旨集, Nov. 2021, Null, Null

腎疾患に繋がる非選択的カチオンチャネルTRPC6変異体における不活性化機構の破綻と腎疾患発症リスク及び発症年齢との連関
岡田 亮, 小牧 竜也, 坂口 怜子, 森 誠之
日本生理学雑誌, Feb. 2022, Null, Null

腎疾患に繋がる非選択的カチオンチャネルTRPC6変異体における不活性化機構の破綻と腎疾患発症リスク及び発症年齢との連関
岡田 亮, 小牧 竜也, 坂口 怜子, 森 誠之
日本生理学雑誌, Feb. 2022, Null, Null
Lead

非選択的カチオンチャネルTRPC6変異体の機能解析に基づくネフローゼ症候群発症年齢の推定
岡田 亮, 小牧 竜也, Polat Onur K., 森 誠之
産業医科大学雑誌, Mar. 2022, Null, Null
Lead

Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade.
Okada Ryo, Zhang Xinwen, Harada Yuka, Wu Zhou, Nakanishi Hiroshi
Inflammation research : official journal of the European Histamine Research Society ... [et al.], May 2018, Reviewed, No invitation
Lead

FSGS関連TRPC6チャネルN末領域変異体におけるCa2+依存的不活性化(CDI)メカニズム破綻の共通性(Common Ca2+-dependent inactivation (CDI)-based mechanism may exist in FSGS mutations in the N-terminal domain of TRPC6 channels)
Mori Masayuki X., Polat Onur K., Okada Ryo, Suzuki Ayaka, Ohmura Sayo, Inoue Ryuji
The Journal of Physiological Sciences, Mar. 2020, Null, Null

Delayed inactivation of TRPC6 as a determinative characteristic of FSGS-associated variants.
Okada Ryo, Sakaguchi Reiko, Komaki Tatsuya, Nonaka Ryu, Polat Onur K, Kihara Takanori, Asanuma Katsuhiko, Yamamoto Takeshi, Isaka Yoshitaka, Mori Yasuo, Mori Masayuki X
The Journal of biological chemistry, May 2025, Reviewed, Null
Lead

Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation.
Mori Masayuki X, Okada Ryo, Sakaguchi Reiko, Hase Hideharu, Imai Yuko, Polat Onur K, Itoh Satoru G, Okumura Hisashi, Mori Yasuo, Okamura Yasushi, Inoue Ryuji
Scientific reports, Jun. 2022, Reviewed, No invitation

TRPC6チャネルのアンキリン反復領域変異はCa2+依存的不活化(CDI)を障害する(Ankyrin-repeat domain mutations of TRPC6 channel impair Ca2+ -dependent inactivation(CDI))
岡田 亮, Polat Onur K., 鈴木 彩日, 大村 紗代, 森 誠之
日本生化学会大会プログラム・講演要旨集, Sep. 2020, Null, Null