Short-chain fatty acid deficiency drives aberrant B cell differentiation in systemic lupus erythematosus
Ryuichiro Kanda; Satoshi Kubo; Kaoru Yamagata; Shigeru Iwata; Yasuyuki Todoroki; Masanobu Ueno; Atsushi Nagayasu; Yurie Satoh-Kanda; Ippei Miyagawa; Koshiro Sonomoto; Yoshiya Tanaka; Shingo Nakayamada
Clinical Immunology, Jun. 2026

Effectiveness and safety of sarilumab in polymyalgia rheumatica: A retrospective study of the FIRST registry
Naoaki Ohkubo; Yusuke Miyazaki; Satoshi Kubo; Ippei Miyagawa; Koshiro Sonomoto; Yoshino Inoue; Yurie Satoh-Kanda; Hiroaki Tanaka; Masanobu Ueno; Atsushi Nagayasu; Takafumi Aritomi; Ryuichiro Kanda; Yuya Fujita; Masashi Funada; Hidenori Sakai; Kiyotake Yoshioka; Mayu Nishimoto; Kazuki Takahashi; Shingo Nakayamada; Yoshiya Tanaka
Modern Rheumatology, Mar. 2026

Biological/targeted synthetic DMARDs do not arrest bone loss in patients with rheumatoid arthritis: a long-term multicenter observational study.
Aritomi T; Sonomoto K; Nakayamada S; Tanaka H; Nagayasu A; Kubo S; Miyagawa I; Yamaguchi A; Ohkubo N; Todoroki Y; Satoh-Kanda Y; Ueno M; Kanda R; Fujita Y; Funada M; Sakai H; Matsunaga S; Tanaka H; Shinojima M; Kawamura H; Takahashi K; Ando M; Haru K; Miyazaki Y; Hanami K; Nawata M; Fukuyo S; Nakatsuka K; Tokunaga M; Saito K; Tanaka Y
Arthritis & rheumatology (Hoboken, N.J.), Mar. 2026

Real-world effectiveness of b/tsDMARD switching in low-inflammatory difficult-to-treat rheumatoid arthritis: insights from the FIRST registry
Hidenori Sakai; Koshiro Sonomoto; Shingo Nakayamada; Masanobu Ueno; Atsushi Nagayasu; Takafumi Aritomi; Hiroaki Tanaka; Satoshi Kubo; Ippei Miyagawa; Yasuyuki Todoroki; Yurie Satoh-Kanda; Yuya Fujita; Ryuichiro Kanda; Yoshiya Tanaka
RMD Open, Jan. 2026

Predicting the progression of difficult-to-treat rheumatoid arthritis by a machine learning scoring system, from the FIRST registry
Masanobu Ueno; Koshiro Sonomoto; Hiroaki Tanaka; Atsushi Nagayasu; Takafumi Aritomi; Ippei Miyagawa; Satoshi Kubo; Yusuke Miyazaki; Yasuyuki Todoroki; Yurie Satoh-Kanda; Yuya Fujita; Hidenori Sakai; Shingo Nakayamada; Yoshiya Tanaka
RMD Open, Jan. 2026

Comparison of tofacitinib, baricitinib, upadacitinib and filgotinib: a 2-year observational study from FIRST registry
Koshiro Sonomoto; Shingo Nakayamada; Hidenori Sakai; Masanobu Ueno; Hiroaki Tanaka; Atsushi Nagayasu; Takafumi Aritomi; Makoto Okawara; Akinori Nakata; Yoshiya Tanaka
RMD Open, Jan. 2026

Influence of Rheumatoid Factors on the Efficacy of TNF Inhibitor Therapy in Patients with Rheumatoid Arthritis
Atsushi Nagayasu; Yusuke Miyazaki; Koshiro Sonomoto; Satoshi Kubo; Ippei Miyagawa; Ayako Yamaguchi; Hiroaki Tanaka; Yasuyuki Todoroki; Masanobu Ueno; Takafumi Aritomi; Yuya Fujita; Hidenori Sakai; Katsunori Suzuki; Shingo Nakayamada; Yoshiya Tanaka
Rheumatology and Therapy, May 2025

Real-World Safety and Efficacy of Targeted Therapies in Rheumatoid Arthritis: A 5-Year, 5130-Case Follow-Up from FIRST Registry.
Sonomoto K; Nakayamada S; Tanaka H; Nagayasu A; Tanaka Y
Rheumatology and therapy, Apr. 2025

Effective Second-Line b/tsDMARDs for Patients with Rheumatoid Arthritis Unresponsive to First-Line b/tsDMARDs from the FIRST Registry.
Kanda R; Miyazaki Y; Nakayamada S; Fukuyo S; Kubo S; Miyagawa I; Yamaguchi A; Satoh-Kanda Y; Ohkubo N; Todoroki Y; Tanaka H; Ueno M; Nagayasu A; Fujita Y; Aritomi T; Kusaka K; Sakai H; Matsunaga S; Nohara H; Tanaka Y
Rheumatology and therapy, Mar. 2025

Induction of interleukin 21 receptor expression via enhanced intracellular metabolism in B cells and its relevance to the disease activity in systemic lupus erythematosus.
Ueno M; Iwata S; Yamagata K; Todoroki Y; Sonomoto K; Nagayasu A; Miyagawa I; Kubo S; Miyazaki Y; Miyata H; Kanda R; Aritomi T; Nakayamada S; Tanaka Y
RMD open, Dec. 2024

Induction of interleukin 21 receptor expression via enhanced intracellular metabolism in B cells and its relevance to the disease activity in systemic lupus erythematosus.
Ueno M; Iwata S; Yamagata K; Todoroki Y; Sonomoto K; Nagayasu A; Miyagawa I; Kubo S; Miyazaki Y; Miyata H; Kanda R; Aritomi T; Nakayamada S; Tanaka Y
RMD open, Dec. 2024

Efficacy and Safety of Biologics in Polymyalgia Rheumatica: A Retrospective Study.
Ohkubo N; Miyazaki Y; Nakayamada S; Fukuyo S; Inoue Y; Satoh-Kanda Y; Tanaka H; Todoroki Y; Miyata H; Nagayasu A; Funada M; Kobayashi H; Sakai H; Kosaka S; Matsunaga S; Tomoyose Y; Nohara H; Tanaka Y
Rheumatology and therapy, Aug. 2024

Efficacy and Safety of Biologics in Polymyalgia Rheumatica: A Retrospective Study.
Ohkubo N; Miyazaki Y; Nakayamada S; Fukuyo S; Inoue Y; Satoh-Kanda Y; Tanaka H; Todoroki Y; Miyata H; Nagayasu A; Funada M; Kobayashi H; Sakai H; Kosaka S; Matsunaga S; Tomoyose Y; Nohara H; Tanaka Y
Rheumatology and therapy, Aug. 2024

Biological/targeted synthetic DMARDs do not arrest bone loss in patients with rheumatoid arthritis: a multicenter prospective observational study.
Sonomoto K; Nakayamada S; Fujino Y; Miyata H; Kubo S; Fujita Y; Inoue Y; Matsunaga S; Iwata S; Hanami K; Todoroki Y; Yoshinari-Korekoda H; Kawabe A; Yamaguchi A; Ueno M; Satoh-Kanda Y; Kanda R; Kanda R; Funada M; Ohkubo N; Kusaka K; Kosaka S; Nagayasu A; Fukuyo S; Nawata M; Miyazaki Y; Tokunaga M; Tanaka K; Okada Y; Tanaka Y
Rheumatology (Oxford, England), Aug. 2024

A Machine Learning Approach for Prediction of CDAI Remission with TNF Inhibitors: A Concept of Precision Medicine from the FIRST Registry.
Sonomoto K; Fujino Y; Tanaka H; Nagayasu A; Nakayamada S; Tanaka Y
Rheumatology and therapy, Apr. 2024

Generation-Dependent Retention Rates and Reasons for Discontinuation of Molecular Targeted Therapies in Patients with Rheumatoid Arthritis: From FIRST Registry.
Kubo S; Miyazaki Y; Todoroki Y; Nagayasu A; Kanda R; Aritomi T; Matsunaga S; Ueno M; Miyagawa I; Sonomoto K; Hanami K; Nakayamada S; Tanaka Y
Rheumatology and therapy, Oct. 2023

Generation-Dependent Retention Rates and Reasons for Discontinuation of Molecular Targeted Therapies in Patients with Rheumatoid Arthritis: From FIRST Registry.
Kubo S; Miyazaki Y; Todoroki Y; Nagayasu A; Kanda R; Aritomi T; Matsunaga S; Ueno M; Miyagawa I; Sonomoto K; Hanami K; Nakayamada S; Tanaka Y
Rheumatology and therapy, Oct. 2023

TGF-β3 in differentiation and function of Tph-like cells and its relevance to disease activity in patients with systemic lupus erythematosus.
Shan Y; Nakayamada S; Nawata A; Yamagata K; Sonomoto K; Tanaka H; Satoh-Kanda Y; Nguyen MP; Todoroki Y; Nagayasu A; Ueno M; Kanda R; Kanda R; Fujita Y; Zhang T; Hao H; Zhou J; Ma X; Anan J; Nguyen AP; Tanaka Y
Rheumatology (Oxford, England), Jul. 2023

Usefulness of ultrasound as a predictor of elderly-onset rheumatoid arthritis with polymyalgia rheumatica-like onset.
Nawata M; Someya K; Kosaka S; Aritomi T; Funada M; Fujita Y; Nagayasu A; Fujino Y; Saito K; Tanaka Y
Modern rheumatology, Mar. 2023

mTOR activation in CD8+ cells contributes to disease activity of rheumatoid arthritis and increases therapeutic response to TNF inhibitors.
Zhang M; Iwata S; Sonomoto K; Ueno M; Fujita Y; Anan J; Miyazaki Y; Ohkubo N; Sumikawa MH; Todoroki Y; Miyata H; Nagayasu A; Kanda R; Kanda R; Hao H; Trimova G; Lee S; Nakayamada S; Sakata K; Tanaka Y
Rheumatology (Oxford, England), Jul. 2022

An enhanced mitochondrial function through glutamine metabolism in plasmablast differentiation in systemic lupus erythematosus.
Sumikawa MH; Iwata S; Zhang M; Miyata H; Ueno M; Todoroki Y; Nagayasu A; Kanda R; Kanda R; Sonomoto K; Torimoto K; Lee S; Nakayamada S; Yamamoto K; Okada Y; Tanaka Y
Rheumatology (Oxford, England), Jul. 2022

Association between ultrasound images and patient-reported outcomes in the treatment of rheumatoid arthritis: a retrospective study.
Nawata M; Someya K; Funada M; Fujita Y; Nagayasu A; Saito K; Tanaka Y
BMC rheumatology, Nov. 2021

Pathological role of activated mTOR in CXCR3+ memory B cells of rheumatoid arthritis.
Iwata S; Zhang M; Hajime M; Ohkubo N; Sonomoto K; Torimoto K; Kitanaga Y; Trimova G; Todoroki Y; Miyata H; Ueno M; Nagayasu A; Kanda R; Nakano K; Nakayamada S; Sakata K; Tanaka Y
Rheumatology (Oxford, England), Nov. 2021

Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells.
Iwata S; Zhang M; Hao H; Trimova G; Hajime M; Miyazaki Y; Ohkubo N; Satoh Kanda Y; Todoroki Y; Miyata H; Ueno M; Nagayasu A; Nakayamada S; Sakata K; Tanaka Y
Frontiers in immunology, Nov. 2020

Severe pulmonary arterial hypertension and interstitial pneumonia related to systemic lupus erythematosus successfully treated with mycophenolate mofetil: A novel case report.
Nawata M; Nagayasu A; Fujita Y; Nawata A; Saito K; Tanaka Y
Lupus, Sep. 2020

Short-term effectiveness of ixekizumab to refractory psoriatic arthritis with spondyloarthritis: two case reports
Atsushi Nagayasu; Masao Nawata; Kazuyoshi Saito; Yoshiya Tanaka
Modern Rheumatology Case Reports, Jul. 2020

Short-term effectiveness of ixekizumab to refractory psoriatic arthritis with spondyloarthritis: two case reports.
Nagayasu A; Nawata M; Saito K; Tanaka Y
Modern rheumatology case reports, Jan. 2020

IgG4-related Pleuritis with Elevated Adenosine Deaminase in Pleural Effusion.
Nagayasu A; Kubo S; Nakano K; Nakayamada S; Iwata S; Miyagawa I; Fukuyo S; Saito K; Tanaka Y
Internal medicine (Tokyo, Japan), Mar. 2018

外転神経麻痺で発症した好酸球性多発血管炎性肉芽腫症の一例
永安 敦, 中野 和久, 宮川 一平, 中山田 真吾, 岩田 慈, 福與 俊介, 久保 智史, 田中 良哉
九州リウマチ, Sep. 2018, Reviewed, Null
Lead

Association between ultrasound images and patient-reported outcomes in the treatment of rheumatoid arthritis: a retrospective study.
Nawata Masao, Someya Kazuki, Funada Masashi, Fujita Yuya, Nagayasu Atsushi, Saito Kazuyoshi, Tanaka Yoshiya
BMC rheumatology, Nov. 2021, Null, Null

胸水中アデノシンデアミナーゼ上昇を伴うIgG4関連胸膜炎(IgG4-related Pleuritis with Elevated Adenosine Deaminase in Pleural Effusion)
Nagayasu Atsushi, Kubo Satoshi, Nakano Kazuhisa, Nakayamada Shingo, Iwata Shigeru, Miyagawa Ippei, Fukuyo Shunsuke, Saito Kazuyoshi, Tanaka Yoshiya
Internal Medicine, Aug. 2018, Reviewed, Null
Lead

Usefulness of Ultrasound as a Predictor of Elderly-Onset Rheumatoid Arthritis with Polymyalgia Rheumatica-Like Onset.
Nawata Masao, Someya Kazuki, Kosaka Shunpei, Aritomi Takafumi, Funada Masashi, Fujita Yuya, Nagayasu Atsushi, Fujino Yoshihisa, Saito Kazuyoshi, Tanaka Yoshiya
Modern rheumatology, Mar. 2022, Reviewed, No invitation

Induction of interleukin 21 receptor expression via enhanced intracellular metabolism in B cells and its relevance to the disease activity in systemic lupus erythematosus.
Ueno Masanobu, Iwata Shigeru, Yamagata Kaoru, Todoroki Yasuyuki, Sonomoto Koshiro, Nagayasu Atsushi, Miyagawa Ippei, Kubo Satoshi, Miyazaki Yusuke, Miyata Hiroko, Kanda Ryuichiro, Aritomi Takafumi, Nakayamada Shingo, Tanaka Yoshiya
RMD open, Dec. 2024, Reviewed, No invitation

Biological/targeted synthetic DMARDs do not arrest bone loss in patients with rheumatoid arthritis: a multicenter prospective observational study.
Sonomoto Koshiro, Nakayamada Shingo, Fujino Yoshihisa, Miyata Hiroko, Kubo Satoshi, Fujita Yuya, Inoue Yoshino, Matsunaga Satsuki, Iwata Shigeru, Hanami Kentaro, Todoroki Yasuyuki, Yoshinari-Korekoda Hiroko, Kawabe Akio, Yamaguchi Ayako, Ueno Masanobu, Satoh-Kanda Yurie, Kanda Ryuichiro, Funada Masashi, Ohkubo Naoaki, Kusaka Katsuhide, Kosaka Shumpei, Nagayasu Atsushi, Fukuyo Shunsuke, Nawata Masao, Miyazaki Yusuke, Tokunaga Mikiko, Tanaka Kenichi, Okada Yosuke, Tanaka Yoshiya
Rheumatology (Oxford, England), Nov. 2023, Reviewed, No invitation

An enhanced mitochondrial function through glutamine metabolism in plasmablast differentiation in systemic lupus erythematosus.
Sumikawa Maiko Hajime, Iwata Shigeru, Zhang Mingzeng, Miyata Hiroko, Ueno Masanobu, Todoroki Yasuyuki, Nagayasu Atsushi, Kanda Ryuichiro, Sonomoto Koshiro, Torimoto Keiichi, Lee Seunghyun, Nakayamada Shingo, Yamamoto Kazuo, Okada Yosuke, Tanaka Yoshiya
Rheumatology (Oxford, England), Nov. 2021, Reviewed, No invitation

TGF-β3 in differentiation and function of Tph-like cells and its relevance to disease activity in patients with systemic lupus erythematosus.
Shan Yu, Nakayamada Shingo, Nawata Aya, Yamagata Kaoru, Sonomoto Koshiro, Tanaka Hiroaki, Satoh-Kanda Yurie, Nguyen Mai-Phuong, Todoroki Yasuyuki, Nagayasu Atsushi, Ueno Masanobu, Kanda Ryuichiro, Fujita Yuya, Zhang Tong, Hao He, Zhou Jieqing, Ma Xiaoxue, Anan Junpei, Nguyen Anh Phuong, Tanaka Yoshiya
Rheumatology (Oxford, England), 2023, Reviewed, No invitation

mTOR activation in CD8+ cells contributes to disease activity of rheumatoid arthritis and increases therapeutic response to TNF inhibitors.
Zhang Mingzeng, Iwata Shigeru, Sonomoto Koshiro, Ueno Masanobu, Fujita Yuya, Anan Junpei, Miyazaki Yusuke, Ohkubo Naoaki, Sumikawa Maiko Hajime, Todoroki Yasuyuki, Miyata Hiroko, Nagayasu Atsushi, Kanda Ryuichiro, Trimova Gulzhan, Lee Seunghyun, Nakayamada Shingo, Sakata Kei, Tanaka Yoshiya
Rheumatology (Oxford, England), Nov. 2021, Reviewed, No invitation

Effective Second-Line b/tsDMARDs for Patients with Rheumatoid Arthritis Unresponsive to First-Line b/tsDMARDs from the FIRST Registry.
Kanda Ryuichiro, Miyazaki Yusuke, Nakayamada Shingo, Fukuyo Shunsuke, Kubo Satoshi, Miyagawa Ippei, Yamaguchi Ayako, Satoh-Kanda Yurie, Ohkubo Naoaki, Todoroki Yasuyuki, Tanaka Hiroaki, Ueno Masanobu, Nagayasu Atsushi, Fujita Yuya, Aritomi Takafumi, Kusaka Katsuhide, Sakai Hidenori, Matsunaga Satsuki, Nohara Hirotsugu, Tanaka Yoshiya
Rheumatology and therapy, Mar. 2025, Reviewed, No invitation

A Machine Learning Approach for Prediction of CDAI Remission with TNF Inhibitors: A Concept of Precision Medicine from the FIRST Registry.
Sonomoto Koshiro, Fujino Yoshihisa, Tanaka Hiroaki, Nagayasu Atsushi, Nakayamada Shingo, Tanaka Yoshiya
Rheumatology and therapy, Mar. 2024, Reviewed, No invitation

Real-World Safety and Efficacy of Targeted Therapies in Rheumatoid Arthritis: A 5-Year, 5130-Case Follow-Up from FIRST Registry.
Sonomoto Koshiro, Nakayamada Shingo, Tanaka Hiroaki, Nagayasu Atsushi, Tanaka Yoshiya
Rheumatology and therapy, Apr. 2025, Reviewed, No invitation

Influence of Rheumatoid Factors on the Efficacy of TNF Inhibitor Therapy in Patients with Rheumatoid Arthritis.
Nagayasu Atsushi, Miyazaki Yusuke, Sonomoto Koshiro, Kubo Satoshi, Miyagawa Ippei, Yamaguchi Ayako, Tanaka Hiroaki, Todoroki Yasuyuki, Ueno Masanobu, Aritomi Takafumi, Fujita Yuya, Sakai Hidenori, Suzuki Katsunori, Nakayamada Shingo, Tanaka Yoshiya
Rheumatology and therapy, Aug. 2025, Reviewed, No invitation
Lead

Efficacy and Safety of Biologics in Polymyalgia Rheumatica: A Retrospective Study.
Ohkubo Naoaki, Miyazaki Yusuke, Nakayamada Shingo, Fukuyo Shunsuke, Inoue Yoshino, Satoh-Kanda Yurie, Tanaka Hiroaki, Todoroki Yasuyuki, Miyata Hiroko, Nagayasu Atsushi, Funada Masashi, Kobayashi Hiroki, Sakai Hidenori, Kosaka Shumpei, Matsunaga Satsuki, Tomoyose Yukiko, Nohara Hirotsugu, Tanaka Yoshiya
Rheumatology and therapy, Oct. 2024, Reviewed, No invitation

Generation-Dependent Retention Rates and Reasons for Discontinuation of Molecular Targeted Therapies in Patients with Rheumatoid Arthritis: From FIRST Registry.
Kubo Satoshi, Miyazaki Yusuke, Todoroki Yasuyuki, Nagayasu Atsushi, Kanda Ryuichiro, Aritomi Takafumi, Matsunaga Satsuki, Ueno Masanobu, Miyagawa Ippei, Sonomoto Koshiro, Hanami Kentaro, Nakayamada Shingo, Tanaka Yoshiya
Rheumatology and therapy, Oct. 2023, Reviewed, No invitation