May 2026
United Japanese Researchers Around the World, United Japanese Researchers Around the World Paper Award 2026

Feb. 2025
Japanese Society for Biomedical Research on Alcohol, Best Presentation Award in the 44th Biomedical Research on Alcohol Academic Conference

Oct. 2021
第５３回日本臨床分子形態学会総会・学術集会 学術集会賞

A novel bead-based assay for selective measurement of arginase 1 activity in human serum.
Kenjiro Nagaoka; Noriyoshi Ogino; Keiki Ogino; Tomotaka Tanabe; Tatsuya Funahashi
Analytical and bioanalytical chemistry, Jan. 2026

Anticancer Activity of 2,3′-Dihydroxy-5′-Methoxystilbene Against NSCLC Cell Lines Through AKT-Dependent Mechanisms: A Comprehensive In Vitro and Computational Analysis
Phisit Pouyfung; Nonthalert Lertnitikul; Noriyoshi Ogino; Achitphol Chookaew; Varisa Pongrakhananon; Piriya Chonsut; Natthaporn Sueangoen; Suwichak Chaisit
International Journal of Molecular Sciences, Jan. 2026

Association of oral frailty and gut microbiota with hypertension: cross-sectional results in the Shika study.
Suzuki F; Mizoguchi R; Karashima S; Ikagawa Y; Tsujiguchi H; Hara A; Miyagi S; Nguyen TTT; Asai A; Katano K; Kasahara T; Sato K; Nakamura M; Shimizu Y; Shibata A; Suzuki K; Kannon T; Ogino N; Tsuboi H; Tajima A; Okamoto S; Nakamura H
Frontiers of medicine, Dec. 2025

L-citrulline, Arginase Activity, and Nitrate As Potential Nitric Oxide-Related Markers of Subclinical Atherosclerosis in Healthy Middle-Aged Non-smokers: A Cross-Sectional Study.
Noriyoshi Ogino; Keiki Ogino; Dai Nogimura; Kazuki Moriyasu; Masahiko Morita; Kenjiro Nagaoka
Cureus, Sep. 2025

Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer.
Xiangyu Gong; Noriyoshi Ogino; M Fátima Leite; Dingyao Zhang; Zehua Chen; Ryan Y Nguyen; Raymond Liu; Emma Kruglov; Kaitlin Flores; Aidan T Cabral; Gabriel Moreira de M Mendes; Barbara E Ehrlich; Michael Mak
Cancer research, May 2025

Usefulness of the Early Increase of Peripheral Blood Lymphocyte Count in Predicting Clinical Outcomes for Patients with Advanced Hepatocellular Carcinoma Treated with Durvalumab Plus Tremelimumab
Yuichi Honma; Michihiko Shibata; Masatoshi Ikemi; Kengo Yoshitomi; Nobuhiko Shinohara; Noriyoshi Ogino; Shinji Oe; Koichiro Miyagawa; Shintaro Abe; Masaru Harada
Cancers, Apr. 2025

好中球エラスターゼによる肝細胞内Ca2+関連タンパク質分解とアルコール性肝炎の肝再生不全
荻野学芳、Barbara E Ehrlich、Michael H Nathanson、原田 大
実験医学, Jan. 2025
Lead

Excess glucose alone induces hepatocyte damage due to oxidative stress and endoplasmic reticulum stress.
Tsuguru Hayashi; Shinji Oe; Koichiro Miyagawa; Masashi Kusanaga; Noriyoshi Ogino; Yuichi Honma; Masaru Harada
Experimental cell research, Oct. 2024

Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis.
Noriyoshi Ogino; M Fatima Leite; Mateus T Guerra; Emma Kruglov; Hiromitsu Asashima; David A Hafler; Takeshi Ito; João P Pereira; Brandon J Peiffer; Zhaoli Sun; Barbara E Ehrlich; Michael H Nathanson
The Journal of clinical investigation, Jun. 2024

Association between animal protein intake, oral frailty and calf circumference in middle-aged and older adults: a cross-sectional analysis from the Shika study.
Fumihiko Suzuki; Shigefumi Okamoto; Shingo Nakai; Sakae Miyagi; Hiromasa Tsujiguchi; Akinori Hara; Thao Thi Thu Nguyen; Yukari Shimizu; Koichiro Hayashi; Keita Suzuki; Tomoko Kasahara; Masaharu Nakamura; Chie Takazawa; Aya Ogawa; Aki Shibata; Takayuki Kannon; Atsushi Tajima; Hirohito Tsuboi; Noriyoshi Ogino; Tadashi Konoshita; Toshinari Takamura; Kuniko Sato; Hiroyuki Nakamura
BMJ open, Feb. 2024

Caspase-4 has a role in cell division in epithelial cells through actin depolymerization.
Kazuhiro Sumida; Tomomitsu Doi; Kunie Obayashi; Yosuke Chiba; Shohei Nagasaka; Noriyoshi Ogino; Koichiro Miyagawa; Ryoko Baba; Hiroyuki Morimoto; Hideki Hara; Takeshi Terabayashi; Toshimasa Ishizaki; Masaru Harada; Motoyoshi Endo
Biochemical and biophysical research communications, Feb. 2024

Adaptation to volumetric compression drives hepatoblastoma cells to an apoptosis-resistant and invasive phenotype.
Xiangyu Gong; Noriyoshi Ogino; M Fatima Leite; Zehua Chen; Ryan Nguyen; Raymond Liu; Emma Kruglov; Kaitlin Flores; Aiden Cabral; Gabriel M M Mendes; Barbara E Ehrlich; Michael Mak
bioRxiv : the preprint server for biology, Oct. 2023

Filter blot method: A simple method for measuring 3-nitrotyrosine in proteins of atmospheric particulate matter.
Noriyoshi Ogino; Keiki Ogino; Masamitsu Eitoku; Narufumi Suganuma; Kenjiro Nagaoka
Environmental pollution (Barking, Essex : 1987), Jul. 2023

Impact of Interferon-Free Direct-Acting Antivirals on the Incidence of Extrahepatic Malignancies in Patients with Chronic Hepatitis C.
Yuichi Honma; Michihiko Shibata; Kahori Morino; Yudai Koya; Tsuguru Hayashi; Noriyoshi Ogino; Masashi Kusanaga; Shinji Oe; Koichiro Miyagawa; Shintaro Abe; Akinari Tabaru; Masaru Harada
Digestive diseases and sciences, Feb. 2023

Association between Bone Mineral Density and Oral Frailty on Renal Function: Findings from the Shika Study.
Shingo Nakai; Fumihiko Suzuki; Shigefumi Okamoto; Sakae Miyagi; Hiromasa Tsujiguchi; Akinori Hara; Thao Thi Thu Nguyen; Yukari Shimizu; Koichiro Hayashi; Keita Suzuki; Tomoko Kasahara; Masaharu Nakamura; Chie Takazawa; Takayuki Kannon; Atsushi Tajima; Hirohito Tsuboi; Noriyoshi Ogino; Tadashi Konoshita; Toshinari Takamura; Hiroyuki Nakamura
Healthcare (Basel, Switzerland), Jan. 2023

Relationship between Alcohol Intake and Chronic Pain with Depressive Symptoms: A Cross-Sectional Analysis of the Shika Study.
Takashi Amatsu; Hiromasa Tsujiguchi; Akinori Hara; Sakae Miyagi; Takayuki Kannon; Keita Suzuki; Yukari Shimizu; Thao Thi Thu Nguyen; Kim-Oanh Pham; Fumihiko Suzuki; Tomoko Kasahara; Masaharu Nakamura; Koichiro Hayashi; Aki Shibata; Noriyoshi Ogino; Tadashi Konoshita; Yasuhiro Kambayashi; Hirohito Tsuboi; Atsushi Tajima; Hiroyuki Nakamura
International journal of environmental research and public health, Feb. 2022

Airborne fine particulate matter in Japan induces lipid synthesis and inhibits autophagy in HepG2 cells.
Noriyoshi Ogino; Koichiro Miyagawa; Kenjiro Nagaoka; Kazuhiro Sumida; Masashi Kusanaga; Shinji Oe; Yuichi Honma; Michihiko Shibata; Masaru Harada; Narufumi Suganuma; Keiki Ogino
The international journal of biochemistry & cell biology, Dec. 2021

Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice.
Noriyoshi Ogino; Kenjiro Nagaoka; Kotomi Tomizuka; Yuki Matsuura-Harada; Masamitsu Eitoku; Narufumi Suganuma; Keiki Ogino
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Oct. 2021

SOD2 mRNA as a potential biomarker for exercise: interventional and cross-sectional research in healthy subjects.
Shihona Ogino; Noriyoshi Ogino; Kotomi Tomizuka; Masamitsu Eitoku; Yosuke Okada; Yoshiya Tanaka; Narufumi Suganuma; Keiki Ogino
Journal of clinical biochemistry and nutrition, Sep. 2021

Possible contribution of hepatocyte secretion to the elevation of plasma exosomal arginase-1 in high-fat diet-fed mice.
Noriyoshi Ogino; Hidekazu Takahashi; Kenjiro Nagaoka; Yuki Harada; Masayuki Kubo; Koichiro Miyagawa; Masashi Kusanaga; Shinji Oe; Yuichi Honma; Masaru Harada; Masamitsu Eitoku; Narufumi Suganuma; Keiki Ogino
Life sciences, Aug. 2021

Correlation of hepatitis C virus-mediated endoplasmic reticulum stress with autophagic flux impairment and hepatocarcinogenesis.
Yuichi Honma; Koichiro Miyagawa; Yuichi Hara; Tsuguru Hayashi; Masashi Kusanaga; Noriyoshi Ogino; Sota Minami; Shinji Oe; Masanori Ikeda; Keisuke Hino; Masaru Harada
Medical molecular morphology, Jun. 2021

The identification of tyrosine-nitrated human serum albumin in airborne particulate matter from Japan
Noriyoshi Ogino; Keiki Ogino; Masamitsu Eitoku; Narufumi Suganuma; Kenjiro Nagaoka; Yasuhiro Kuramitsu
Atmospheric Pollution Research, May 2021

Role of HO-1 against Saturated Fatty Acid-Induced Oxidative Stress in Hepatocytes.
Noriyoshi Ogino; Koichiro Miyagawa; Kenjiro Nagaoka; Yuki Matsuura-Harada; Shihona Ogino; Masashi Kusanaga; Shinji Oe; Yuichi Honma; Masaru Harada; Masamitsu Eitoku; Narufumi Suganuma; Keiki Ogino
Nutrients, Mar. 2021

大気中のparticulate matter(PM)に含有されるタンパク質の同定
荻野 景規; 荻野 学芳; 長岡 憲次郎; 栄徳 勝光; 菅沼 成文
日本衛生学雑誌, Mar. 2021

運動習慣を反映する血中ミトコンドリアバイオマーカーの検討
荻野 景規; 荻野 志穂奈; 富塚 琴美; 荻野 学芳; 栄徳 勝光; 菅沼 成文
日本衛生学雑誌, Mar. 2021

Plasma Arginase-1 Level Is Associated with the Mental Status of Outpatients with Chronic Liver Disease.
Noriyoshi Ogino; Fusao Ikeda; Shihoko Namba; Shinnosuke Ohkubo; Tomoaki Nishimura; Hiroyuki Okada; Satoshi Hirohata; Narufumi Suganuma; Keiki Ogino
Diagnostics (Basel, Switzerland), Feb. 2021

Importance of a Liver Biopsy in the Management of Wilson Disease.
Shinji Oe; Yuichi Honma; Kei Yabuki; Kahori Morino; Keiichiro Kumamoto; Tsuguru Hayashi; Masashi Kusanaga; Noriyoshi Ogino; Sota Minami; Michihiko Shibata; Shintaro Abe; Masaru Harada
Internal medicine (Tokyo, Japan), Jan. 2020

Involvement of sarco/endoplasmic reticulum calcium ATPase-mediated calcium flux in the protective effect of oleic acid against lipotoxicity in hepatocytes.
Noriyoshi Ogino; Koichiro Miyagawa; Masashi Kusanaga; Tsuguru Hayashi; Sota Minami; Shinji Oe; Yuichi Honma; Masaru Harada
Experimental cell research, Dec. 2019

Effect of direct-acting antivirals on platelet-associated immunoglobulin G and thrombocytopenia in hepatitis C virus-related chronic liver disease.
Yuichi Honma; Michihiko Shibata; Tsuguru Hayashi; Masashi Kusanaga; Noriyoshi Ogino; Sota Minami; Shinsuke Kumei; Shinji Oe; Koichiro Miyagawa; Michio Senju; Hidehiko Matsuoka; Tatsuyuki Watanabe; Masaaki Hiura; Shintaro Abe; Masaru Harada
Liver international : official journal of the International Association for the Study of the Liver, Sep. 2019

Human albumin augmented airway inflammation induced by PM2.5 in NC/Nga mice.
Kenjiro Nagaoka; Keiki Ogino; Noriyoshi Ogino; Tatsuo Ito; Kei Takemoto; Shihona Ogino; Yuka Seki; Hiroki Hamada; Yoshihisa Fujikura
Environmental toxicology, Jul. 2019

Zinc Attenuates the Cytotoxicity of Some Stimuli by Reducing Endoplasmic Reticulum Stress in Hepatocytes.
Masashi Kusanaga; Shinji Oe; Noriyoshi Ogino; Sota Minami; Koichiro Miyagawa; Yuichi Honma; Masaru Harada
International journal of molecular sciences, May 2019

Association between Occupational Dysfunction and Metabolic Syndrome in Community-Dwelling Japanese Adults in a Cross-Sectional Study: Ibara Study.
Yuki Miyake; Eri Eguchi; Hiroshi Ito; Kazufumi Nakamura; Tatsuo Ito; Kenjiro Nagaoka; Noriyoshi Ogino; Keiki Ogino
International journal of environmental research and public health, Nov. 2018

A Young Adult Patient with Nonalcoholic Steatohepatitis Developed Severe Gastroesophageal Varices Associated with Severe Obesity and Diabetes Mellitus.
Yuichi Honma; Kazuhiro Sumida; Noriyoshi Ogino; Masashi Kusanaga; Sota Minami; Shinsuke Kumei; Hidehiko Matsuoka; Tatsuyuki Watanabe; Masaaki Hiura; Shintaro Abe; Michihiko Shibata; Masaru Harada
Case reports in gastroenterology, 2018

Involvement of PM2.5-bound protein and metals in PM2.5-induced allergic airway inflammation in mice.
Keiki Ogino; Kenjiro Nagaoka; Tatsuo Ito; Kei Takemoto; Tomoaki Okuda; Shoji F Nakayama; Noriyoshi Ogino; Yuka Seki; Hiroki Hamada; Shogo Takashiba; Yoshihisa Fujikura
Inhalation toxicology, 2018

Serum Albumin Concentrations Predict hypovolaemia Caused by Polyethylene Glycol Plus Ascorbic Acid Prior to Colonoscopy in Elderly Patients.
Noriyoshi Ogino; Gentaro Aridome; Junji Oshima; Michihiko Shibata; Tatsuyuki Watanabe; Keiichiro Kume; Ichiro Yoshikawa; Masaru Harada
Drugs & aging, May 2016

The identification of tyrosine-nitrated human serum albumin in airborne particulate matter from Japan.
Ogino N, Ogino K, Eitoku M, Suganuma N, Nagaoka K, Kuramitsu Y.
Atmospheric Pollution Research, May 2021, Reviewed, Null
Lead, Corresponding

Caspase-4 has a role in cell division in epithelial cells through actin depolymerization.
Sumida K, Doi T, Obayashi K, Chiba Y, Nagasaka S, Ogino N, Miyagawa K, Baba R, Morimoto H, Hara H, Terabayashi T, Ishizaki T, Harada M, Endo M
Biochemical and Biophysical Research Communications, Feb. 2024, Reviewed, Null

Adaptation to volumetric compression drives an Apoptosis-Resistant and invasive phenotype in liver cancer.
Gong X, Ogino N, Leite M F, Zhang D, Chen Z, Nguyen R Y, Liu R Kruglov E, Flores K, Cabral A T, Moreira de M Mendes G, Ehrlich B E, Mak M
Cancer Research, Aug. 2025, Reviewed, Null

Plasma arginase-1 level is associated with the mental status of outpatients with chronic liver disease.
Ogino N, Ikeda F, Namba S, Ohkubo S, Nishimura T, Okada H, Hirohata S, Suganuma N, Ogino K
Diagnostics (Basel, Switzerland), Feb. 2021, Reviewed, Null
Lead, Corresponding

Impact of Interferon-free direct-acting antivirals on the incidence of extrahepatic malignancies in patients with chronic hepatitis C.
Honma Y, Shibata M, Morino K, Koya Y, Hayashi T, Ogino N, Kusanaga M, Oe S, Miyagawa K, Abe S, Tabaru A, Harada M
Digestive diseases and sciences, Feb. 2023, Reviewed, Null

Serum Albumin Concentrations Predict hypovolaemia Caused by Polyethylene Glycol Plus Ascorbic Acid Prior to Colonoscopy in Elderly Patients.
Ogino Noriyoshi, Aridome Gentaro, Oshima Junji, Shibata Michihiko, Watanabe Tatsuyuki, Kume Keiichiro, Yoshikawa Ichiro, Harada Masaru
Drugs & aging, May 2016, Reviewed, Null
Lead, Corresponding

Excess glucose alone induces hepatocyte damage due to oxidative stress and endoplasmic reticulum stress.
Hayashi T, Oe S, Miyagawa K, Kusanaga M, Ogino N, Honma Y, Harada M
Experimental Cell Research, Oct. 2024, Reviewed, Null

Involvement of sarco/endoplasmic reticulum calcium ATPase-mediated calcium flux in the protective effect of oleic acid against lipotoxicity in hepatocytes.
Ogino N, Miyagawa K, Kusanaga M, Hayashi T, Minami S, Oe S, Honma Y, Harada M.
Experimental Cell Research, Dec. 2019, Reviewed, Null
Lead, Corresponding

Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice.
Ogino N, Nagaoka K, Tomizuka K, Matsuura-Harada Y, Eitoku M, Suganuma N, Ogino K
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Oct. 2021, Reviewed, Null
Lead

Relationship between Alcohol Intake and Chronic Pain with Depressive Symptoms: A Cross-Sectional Analysis of the Shika Study.
Amatsu T, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Shimizu Y, Nguyen T Thi T, Pham Kim-O, Suzuki F, Kasahara T, Nakamura M, Hayashi K, Shibata A, Ogino N, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Nakamura H
International journal of environmental research and public health, Feb. 2022, Reviewed, Null

Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis.
Ogino N, Leite M F, Guerra M T, Kruglov E, Asashima H, Hafler D A, Ito T, Pereira J P, Peiffer B J, Sun Z Ehrlich B E, Nathanson M H
The Journal of Clinical Investigation, Jun. 2024, Reviewed, Null
Lead

SOD2 mRNA as a potential biomarker for exercise: interventional and cross-sectional research in healthy subjects.
Ogino Shihona, Ogino Noriyoshi, Tomizuka Kotomi, Eitoku Masamitsu, Okada Yosuke, Tanaka Yoshiya, Suganuma Narufumi, Ogino Keiki
Journal of clinical biochemistry and nutrition, Sep. 2021, Reviewed, No invitation

Possible contribution of hepatocyte secretion to the elevation of plasma exosomal arginase-1 in high-fat diet-fed mice.
Ogino N, Takahashi H, Nagaoka K, Harada Y, Kubo M, Miyagawa K, Kusanaga M, Oe S, Honma Y, Harada M, Eitoku M, Suganuma N, Ogino K
Life sciences, May 2021, Reviewed, Null
Lead

Effect of direct-acting antivirals on platelet-associated immunoglobulin G and thrombocytopenia in hepatitis C virus-related chronic liver disease.
Honma Y, Shibata M, Hayashi T, Kusanaga M, Ogino N, Minami S, Kumei S, Oe S, Miyagawa K, Senju M, Matsuoka H, Watanabe T, Hiura M, Abe S, Harada M.
Liver International, Sep. 2019, Reviewed, Null

Correlation of hepatitis C virus-mediated endoplasmic reticulum stress with autophagic flux impairment and hepatocarcinogenesis.
Honma Y, Miyagawa K, Hara Y, Hayashi T, Kusanaga M, Ogino N, Minami S, Oe S, Ikeda M, Hino K, Harada M．
Medical molecular morphology, Jun. 2021, Reviewed, Null

Role of HO-1 against saturated fatty acid-induced oxidative stress in hepatocytes.
Ogino N, Miyagawa K, Nagaoka K, Matsuura-Harada Y, Ogino S, Kusanaga M, Oe S, Honma Y, Harada M, Eitoku M, Suganuma N, Ogino K
Nutrients, Mar. 2021, Reviewed, Null
Lead

Airborne fine particulate matter in Japan induces lipid synthesis and inhibits autophagy in HepG2 cells.
Ogino N, Miyagawa K, Nagaoka K, Sumida K, Kusanaga M, Oe S, Honma Y, Shibata M, Harada M, Suganuma N, Ogino K
The international journal of biochemistry & cell biology, Dec. 2021, Reviewed, Null
Lead, Corresponding

A young adult patient with nonalcoholic steatohepatitis developed severe gastroesophageal varices associated with severe obesity and diabetes mellitus.
Honma Y, Sumida K, Ogino N, Kusanaga M, Minami S, Kumei S, Matsuoka H, Watanabe T, Hiura M, Abe S, Shibata M, Harada M
Case reports in gastroenterology, Aug. 2018, Reviewed, Null